CFD complement factor D [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CFDprovided by VGNC
Official Full Name: complement factor Dprovided by VGNC
Primary source: VGNC:VGNC:39174
See related: Ensembl:ENSCAFG00845014517
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (58527568..58530058, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (57587313..57589790, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (58265041..58267518, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (57582382..57584835, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (58062090..58064488, complement)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: complement factor D

XP_013977853.1

EC 3.4.21.46

XP_038285291.1

EC 3.4.21.46

XP_038285292.1

EC 3.4.21.46

XP_038360816.1

EC 3.4.21.46

XP_038360817.1

EC 3.4.21.46

XP_038423974.1

EC 3.4.21.46

XP_038423975.1

EC 3.4.21.46

XP_038488083.1

EC 3.4.21.46

XP_038488084.1

EC 3.4.21.46

XP_542213.4

EC 3.4.21.46

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051824.1 Reference ROS_Cfam_1.0

Range

58527568..58530058 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038429364.1 → XP_038285292.1 complement factor D isoform X2

UniProtKB/TrEMBL

A0A8C0KZD4, A0A8C0NV83, A0A8I3NTV7

Related

ENSCAFP00845020496.1, ENSCAFT00845025998.1

Conserved Domains (1) summary

cd00190
Location:29 → 252

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_038429363.1 → XP_038285291.1 complement factor D isoform X1

UniProtKB/TrEMBL

A0A8C0S7R6, A0A8I3NIC8

Related

ENSCAFP00845020471.1, ENSCAFT00845025968.1

Conserved Domains (1) summary

cd00190
Location:114 → 337

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049280.1 Alternate UMICH_Zoey_3.1

Range

57582382..57584835 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038504889.1 → XP_038360817.1 complement factor D isoform X2

Conserved Domains (1) summary

cd00190
Location:29 → 252

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_038504888.1 → XP_038360816.1 complement factor D isoform X1

Conserved Domains (1) summary

cd00190
Location:114 → 337

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049761.1 Alternate UNSW_CanFamBas_1.0

Range

58062090..58064488 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038632156.1 → XP_038488084.1 complement factor D isoform X2

Conserved Domains (1) summary

cd00190
Location:29 → 252

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_038632155.1 → XP_038488083.1 complement factor D isoform X1

Conserved Domains (1) summary

cd00190
Location:114 → 337

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049241.1 Alternate UU_Cfam_GSD_1.0

Range

58265041..58267518 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038568047.1 → XP_038423975.1 complement factor D isoform X2

UniProtKB/TrEMBL

A0A8C0KZD4, A0A8C0NV83, A0A8I3NTV7

Conserved Domains (1) summary

cd00190
Location:29 → 252

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_038568046.1 → XP_038423974.1 complement factor D isoform X1

UniProtKB/TrEMBL

A0A8C0S7R6, A0A8I3NIC8

Conserved Domains (1) summary

cd00190
Location:114 → 337

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

57587313..57589790 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_542213.8 → XP_542213.4 complement factor D isoform X2

UniProtKB/TrEMBL

A0A8C0KZD4, A0A8C0NV83, A0A8I3NTV7

Conserved Domains (1) summary

cd00190
Location:29 → 252

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_014122378.3 → XP_013977853.1 complement factor D isoform X1

UniProtKB/TrEMBL

A0A8C0S7R6, A0A8I3NIC8

Conserved Domains (1) summary

cd00190
Location:114 → 337

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...