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VAV1 vav guanine nucleotide exchange factor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 485016, updated on 5-Mar-2024

Summary

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Official Symbol
VAV1provided by VGNC
Official Full Name
vav guanine nucleotide exchange factor 1provided by VGNC
Primary source
VGNC:VGNC:48236
See related
Ensembl:ENSCAFG00845008896
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
27
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (54137307..54187259, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (53231024..53280874, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (53881726..53931647, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (53204407..53254232, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (53652377..53702224, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene EGF-like module containing, mucin-like, hormone receptor-like sequence 4 Neighboring gene adhesion G protein-coupled receptor E1 Neighboring gene SH2 domain containing 3A Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene G protein-coupled receptor 108

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene vav
Names
vav 1 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    54137307..54187259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038428850.1 → XP_038284778.1  proto-oncogene vav isoform X1

    UniProtKB/TrEMBL
    A0A8C0L8F8, A0A8C0NQT9, A0A8C0TND5, A0A8I3N5Q7, A0A8I3NA65
    Related
    ENSCAFP00845012298.1, ENSCAFT00845015810.1
    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786 → 839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

  2. XM_038428851.1 → XP_038284779.1  proto-oncogene vav isoform X2

    UniProtKB/TrEMBL
    A0A8C0TND5, A0A8I3N5Q7
    Related
    ENSCAFP00845012423.1, ENSCAFT00845015966.1
    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:785 → 838
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    53204407..53254232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038504479.1 → XP_038360407.1  proto-oncogene vav isoform X1

    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786 → 839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

  2. XM_038504480.1 → XP_038360408.1  proto-oncogene vav isoform X2

    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:785 → 838
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    53652377..53702224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038631678.1 → XP_038487606.1  proto-oncogene vav isoform X1

    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786 → 839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

  2. XM_038631679.1 → XP_038487607.1  proto-oncogene vav isoform X2

    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:785 → 838
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    53881726..53931647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038567529.1 → XP_038423457.1  proto-oncogene vav isoform X1

    UniProtKB/TrEMBL
    A0A8C0L8F8, A0A8C0NQT9, A0A8C0TND5, A0A8I3N5Q7, A0A8I3NA65
    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786 → 839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

  2. XM_038567530.1 → XP_038423458.1  proto-oncogene vav isoform X2

    UniProtKB/TrEMBL
    A0A8C0TND5, A0A8I3N5Q7
    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:785 → 838
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    53231024..53280874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_542134.7 → XP_542134.2  proto-oncogene vav isoform X1

    UniProtKB/TrEMBL
    A0A8C0L8F8, A0A8C0NQT9, A0A8C0TND5, A0A8I3N5Q7, A0A8I3NA65
    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786 → 839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein

  2. XM_005632964.4 → XP_005633021.1  proto-oncogene vav isoform X2

    UniProtKB/TrEMBL
    A0A8C0TND5, A0A8I3N5Q7
    Conserved Domains (7) summary
    cd10405
    Location:665 → 767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:785 → 838
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596 → 658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00160
    Location:195 → 371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385 → 508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21262
    Location:2 → 121
    CH_VAV1; calponin homology (CH) domain found in VAV1 protein
    cd20867
    Location:510 → 566
    C1_VAV1; protein kinase C conserved region 1 (C1 domain) found in VAV1 protein
Nucleotide Protein
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