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WNT5A Wnt family member 5A [ Canis lupus familiaris (dog) ]

Gene ID: 484721, updated on 5-Mar-2024

Summary

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Official Symbol
WNT5Aprovided by VGNC
Official Full Name
Wnt family member 5Aprovided by VGNC
Primary source
VGNC:VGNC:48425
See related
Ensembl:ENSCAFG00845026417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See WNT5A in Genome Data Viewer
Location:
chromosome: 20
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (35028713..35063140)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (34700143..34711111)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (35066932..35077922)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (34490948..34501920)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (34851115..34862094)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene uncharacterized LOC111091308 Neighboring gene uncharacterized LOC111091309 Neighboring gene U4 spliceosomal RNA Neighboring gene peroxiredoxin-1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-Ras(V12) -induced cell transformation. Lin HK, et al. J Cell Mol Med, 2018 May. PMID 29502342, Free PMC Article
  2. Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition. Chen YS, et al. Mol Cell Proteomics, 2011 Feb. PMID 20511395, Free PMC Article
  3. Quantitative analysis of mRNA transcripts of Hox, SHH, PTCH, Wnt, and Fzd genes in canine hematopoietic progenitor cells and various in vitro colonies differentiated from the cells. Ide K, et al. J Vet Med Sci, 2009 Jan. PMID 19194078

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cav1-dependent repression of Fzd2 and exosome uptake is potentially relevant to its antitransformation activity, which hinders the activation of Ha-Ras(V12) -Wnt5a-Stat3 pathway.
    Title: Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-Ras(V12) -induced cell transformation.
  2. Wnt-5a is involved during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition
    Title: Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein Wnt-5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287075.1 → NP_001274004.1  protein Wnt-5a precursor

    See identical proteins and their annotated locations for NP_001274004.1

    Status: PROVISIONAL

    Source sequence(s)
    JAAUVH010000291
    UniProtKB/TrEMBL
    A0A8C0ST35, A0A8I3PZV4
    Conserved Domains (1) summary
    cd19347
    Location:49 → 360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    35028713..35063140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426449.1 → XP_038282377.1  protein Wnt-5a isoform X2

    UniProtKB/TrEMBL
    A0A8C0ST35, A0A8I3PZV4
    Conserved Domains (1) summary
    cd19347
    Location:49 → 360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

  2. XM_038426450.1 → XP_038282378.1  protein Wnt-5a isoform X2

    UniProtKB/TrEMBL
    A0A8C0ST35, A0A8I3PZV4
    Conserved Domains (1) summary
    cd19347
    Location:49 → 360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

  3. XM_038426452.1 → XP_038282380.1  protein Wnt-5a isoform X2

    UniProtKB/TrEMBL
    A0A8C0ST35, A0A8I3PZV4
    Conserved Domains (1) summary
    cd19347
    Location:49 → 360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

  4. XM_038426455.1 → XP_038282383.1  protein Wnt-5a isoform X2

    UniProtKB/TrEMBL
    A0A8C0ST35, A0A8I3PZV4
    Conserved Domains (1) summary
    cd19347
    Location:49 → 360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

  5. XM_038426453.1 → XP_038282381.1  protein Wnt-5a isoform X2

    UniProtKB/TrEMBL
    A0A8C0ST35, A0A8I3PZV4
    Conserved Domains (1) summary
    cd19347
    Location:49 → 360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

  6. XM_038426451.1 → XP_038282379.1  protein Wnt-5a isoform X2

    UniProtKB/TrEMBL
    A0A8C0ST35, A0A8I3PZV4
    Related
    ENSCAFP00845036615.1, ENSCAFT00845046646.1
    Conserved Domains (1) summary
    cd19347
    Location:49 → 360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

  7. XM_038426448.1 → XP_038282376.1  protein Wnt-5a isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVW5, A0A8C0PW76, A0A8C0ST35, A0A8I3PPD9, A0A8I3PZV4
    Related
    ENSCAFP00845036579.1, ENSCAFT00845046592.1
    Conserved Domains (1) summary
    cd19347
    Location:69 → 380
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    34490948..34501920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    34851115..34862094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    35066932..35077922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    34700143..34711111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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