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RAF1 Raf-1 proto-oncogene, serine/threonine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 484648, updated on 5-Mar-2024

Summary

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Official Symbol
RAF1provided by VGNC
Official Full Name
Raf-1 proto-oncogene, serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:45325
See related
Ensembl:ENSCAFG00845028676
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See RAF1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (5921808..6000868)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (5929501..6009310)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (5966879..6046000)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (5637969..5717035)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (5991105..6070948)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene cullin associated and neddylation dissociated 2 (putative) Neighboring gene transmembrane protein 40 Neighboring gene makorin ring finger protein 2 Neighboring gene thymosin beta-4-like Neighboring gene replication protein A 32 kDa subunit-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
RAF proto-oncogene serine/threonine-protein kinase
Names
v-raf-1 murine leukemia viral oncogene homolog 1
XP_005632198.1
XP_022262065.1
XP_022262066.1
XP_038282819.1
XP_038282820.1
XP_038282821.1
XP_038282822.1
XP_038282823.1
XP_038311911.1
XP_038358616.1
XP_038358617.1
XP_038358618.1
XP_038358619.1
XP_038358620.1
XP_038421534.1
XP_038421535.1
XP_038421536.1
XP_038421537.1
XP_038421538.1
XP_038485666.1
XP_038485667.1
XP_038485668.1
XP_038485670.1
XP_038485671.1
XP_859234.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    5921808..6000868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426891.1 → XP_038282819.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
    Related
    ENSCAFP00845039725.1, ENSCAFT00845050674.1
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  2. XM_038426893.1 → XP_038282821.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8C0P9J5, A0A8C0QWX8, A0A8P0TAW9
    Related
    ENSCAFP00845039751.1, ENSCAFT00845050706.1
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  3. XM_038426892.1 → XP_038282820.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  4. XM_038426894.1 → XP_038282822.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q532, A0A8P0NRR2
    Conserved Domains (2) summary
    cd14149
    Location:275 → 557
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_038426895.1 → XP_038282823.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q532, A0A8P0NRR2
    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    5637969..5717035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038502688.1 → XP_038358616.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  2. XM_038502690.1 → XP_038358618.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  3. XM_038502689.1 → XP_038358617.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  4. XM_038502691.1 → XP_038358619.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    Conserved Domains (2) summary
    cd14149
    Location:275 → 557
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_038502692.1 → XP_038358620.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    5991105..6070948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038629738.1 → XP_038485666.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  2. XM_038629740.1 → XP_038485668.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  3. XM_038629739.1 → XP_038485667.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  4. XM_038629742.1 → XP_038485670.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    Conserved Domains (2) summary
    cd14149
    Location:275 → 557
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_038629743.1 → XP_038485671.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    5966879..6046000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038565606.1 → XP_038421534.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  2. XM_038565608.1 → XP_038421536.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8C0P9J5, A0A8C0QWX8, A0A8P0TAW9
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  3. XM_038565607.1 → XP_038421535.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  4. XM_038565609.1 → XP_038421537.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q532, A0A8P0NRR2
    Conserved Domains (2) summary
    cd14149
    Location:275 → 557
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_038565610.1 → XP_038421538.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q532, A0A8P0NRR2
    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    5929501..6009310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005632141.1 → XP_005632198.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  2. XM_854141.3 → XP_859234.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0A8C0P9J5, A0A8C0QWX8, A0A8P0TAW9
    Conserved Domains (3) summary
    cd14149
    Location:336 → 618
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  3. XM_022406357.1 → XP_022262065.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0A8C0TEU4, A0A8I3PZA0, A0A8P0TAW9
    Conserved Domains (3) summary
    cd14149
    Location:356 → 638
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd17135
    Location:55 → 131
    RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
    cd20870
    Location:136 → 187
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  4. XM_038455983.1 → XP_038311911.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q532, A0A8P0NRR2
    Conserved Domains (2) summary
    cd14149
    Location:275 → 557
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

  5. XM_022406358.1 → XP_022262066.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    A0A8I3Q532, A0A8P0NRR2
    Conserved Domains (2) summary
    cd14149
    Location:255 → 537
    STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
    cd20870
    Location:55 → 106
    C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
Nucleotide Protein
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