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MCM2 minichromosome maintenance complex component 2 [ Canis lupus familiaris (dog) ]

Gene ID: 484622, updated on 5-Mar-2024

Summary

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Official Symbol
MCM2provided by VGNC
Official Full Name
minichromosome maintenance complex component 2provided by VGNC
Primary source
VGNC:VGNC:43081
See related
Ensembl:ENSCAFG00845013762
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See MCM2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (1703569..1724253)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (1719696..1740375)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (1712467..1733169)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (1424901..1445586)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (1752661..1773346)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102154894 Neighboring gene transmembrane protein adipocyte associated 1 Neighboring gene podocalyxin like 2 Neighboring gene ankyrin repeat and BTB domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA unwinding involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA replication licensing factor MCM2
XP_038282661.1
XP_038282662.1
XP_038311700.1
XP_038311701.1
XP_038358469.1
XP_038358470.1
XP_038421382.1
XP_038421383.1
XP_038485502.1
XP_038485503.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    1703569..1724253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426733.1 → XP_038282661.1  DNA replication licensing factor MCM2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUP0, A0A8C0MZR6, A0A8C0TZW4, A0A8I3NR86
    Related
    ENSCAFP00845019311.1, ENSCAFT00845024552.1
    Conserved Domains (3) summary
    smart00350
    Location:291 → 802
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:72 → 182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:197 → 286
    MCM_N; MCM N-terminal domain

  2. XM_038426734.1 → XP_038282662.1  DNA replication licensing factor MCM2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MZR6
    Conserved Domains (3) summary
    smart00350
    Location:258 → 769
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:39 → 149
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:164 → 253
    MCM_N; MCM N-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    1424901..1445586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038502541.1 → XP_038358469.1  DNA replication licensing factor MCM2 isoform X1

    Conserved Domains (3) summary
    smart00350
    Location:291 → 802
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:72 → 182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:197 → 286
    MCM_N; MCM N-terminal domain

  2. XM_038502542.1 → XP_038358470.1  DNA replication licensing factor MCM2 isoform X2

    Conserved Domains (3) summary
    smart00350
    Location:258 → 769
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:39 → 149
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:164 → 253
    MCM_N; MCM N-terminal domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    1752661..1773346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038629574.1 → XP_038485502.1  DNA replication licensing factor MCM2 isoform X1

    Conserved Domains (3) summary
    smart00350
    Location:291 → 802
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:72 → 182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:197 → 286
    MCM_N; MCM N-terminal domain

  2. XM_038629575.1 → XP_038485503.1  DNA replication licensing factor MCM2 isoform X2

    Conserved Domains (3) summary
    smart00350
    Location:258 → 769
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:39 → 149
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:164 → 253
    MCM_N; MCM N-terminal domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    1712467..1733169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038565454.1 → XP_038421382.1  DNA replication licensing factor MCM2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUP0, A0A8C0MZR6, A0A8C0TZW4, A0A8I3NR86
    Conserved Domains (3) summary
    smart00350
    Location:291 → 802
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:72 → 182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:197 → 286
    MCM_N; MCM N-terminal domain

  2. XM_038565455.1 → XP_038421383.1  DNA replication licensing factor MCM2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MZR6
    Conserved Domains (3) summary
    smart00350
    Location:258 → 769
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:39 → 149
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:164 → 253
    MCM_N; MCM N-terminal domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1719696..1740375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038455772.1 → XP_038311700.1  DNA replication licensing factor MCM2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUP0, A0A8C0MZR6, A0A8C0TZW4, A0A8I3NR86
    Conserved Domains (3) summary
    smart00350
    Location:291 → 802
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:72 → 182
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:197 → 286
    MCM_N; MCM N-terminal domain

  2. XM_038455773.1 → XP_038311701.1  DNA replication licensing factor MCM2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MZR6
    Conserved Domains (3) summary
    smart00350
    Location:258 → 769
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:39 → 149
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:164 → 253
    MCM_N; MCM N-terminal domain
Nucleotide Protein
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