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AP2A1 adaptor related protein complex 2 subunit alpha 1 [ Canis lupus familiaris (dog) ]

Gene ID: 484375, updated on 5-Mar-2024

Summary

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Official Symbol
AP2A1provided by VGNC
Official Full Name
adaptor related protein complex 2 subunit alpha 1provided by VGNC
Primary source
VGNC:VGNC:37958
See related
Ensembl:ENSCAFG00845021617
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
24
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (107273281..107305783, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (106335247..106367722, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (107427815..107460313, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (106945343..106977824, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (106587348..106619846, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 25 Neighboring gene uncharacterized LOC106559652 Neighboring gene fuzzy planar cell polarity protein Neighboring gene uncharacterized LOC119870939 Neighboring gene testis specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
AP-2 complex subunit alpha-1
Names
adaptor related protein complex 2 alpha 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    107273281..107305783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038656273.1 → XP_038512201.1  AP-2 complex subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LLQ7, A0A8C0LU67, A0A8I3S2R3
    Related
    ENSCAFP00845030220.1, ENSCAFT00845038604.1
    Conserved Domains (4) summary
    smart00809
    Location:734 → 837
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:843 → 951
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  2. XM_038656272.1 → XP_038512200.1  AP-2 complex subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LDG5, A0A8C0M3V6, A0A8I3S565
    Related
    ENSCAFP00845030062.1, ENSCAFT00845038395.1
    Conserved Domains (4) summary
    smart00809
    Location:756 → 859
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:865 → 973
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    106945343..106977824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038467482.1 → XP_038323410.1  AP-2 complex subunit alpha-1 isoform X2

    Conserved Domains (4) summary
    smart00809
    Location:734 → 837
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:843 → 951
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  2. XM_038467481.1 → XP_038323409.1  AP-2 complex subunit alpha-1 isoform X1

    Conserved Domains (4) summary
    smart00809
    Location:756 → 859
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:865 → 973
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    106587348..106619846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038592482.1 → XP_038448410.1  AP-2 complex subunit alpha-1 isoform X2

    Conserved Domains (4) summary
    smart00809
    Location:734 → 837
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:843 → 951
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  2. XM_038592481.1 → XP_038448409.1  AP-2 complex subunit alpha-1 isoform X1

    Conserved Domains (4) summary
    smart00809
    Location:756 → 859
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:865 → 973
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    107427815..107460313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038528187.1 → XP_038384115.1  AP-2 complex subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LLQ7, A0A8C0LU67, A0A8I3S2R3
    Conserved Domains (4) summary
    smart00809
    Location:734 → 837
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:843 → 951
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  2. XM_038528186.1 → XP_038384114.1  AP-2 complex subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LDG5, A0A8C0M3V6, A0A8I3S565
    Conserved Domains (4) summary
    smart00809
    Location:756 → 859
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:865 → 973
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    106335247..106367722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003638815.4 → XP_003638863.1  AP-2 complex subunit alpha-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LLQ7, A0A8C0LU67, A0A8I3S2R3
    Conserved Domains (4) summary
    smart00809
    Location:734 → 837
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:843 → 951
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  2. XM_541490.7 → XP_541490.4  AP-2 complex subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LDG5, A0A8C0M3V6, A0A8I3S565
    Conserved Domains (4) summary
    smart00809
    Location:756 → 859
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:865 → 973
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein
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