U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SYK spleen associated tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 484196, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
SYKprovided by VGNC
Official Full Name
spleen associated tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:47021
See related
Ensembl:ENSCAFG00845018106
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (96507029..96590534, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (96356719..96440184, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (96615264..96698710, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (96134620..96217990, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (95855025..95938496, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119869699 Neighboring gene uncharacterized LOC119869704 Neighboring gene uncharacterized LOC106559506 Neighboring gene uncharacterized LOC111097044 Neighboring gene DIRAS family GTPase 2 Neighboring gene uncharacterized LOC111097047

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZAP-70 and Syk expression in canine lymphoid cells and preliminary results on leukaemia cases. Mortarino M, et al. Vet Immunol Immunopathol, 2009 Apr 15. PMID 19144411
  2. Comparative radiation hybrid map of canine chromosome 1 incorporating SNP and indel polymorphisms. Housley DJ, et al. Genomics, 2004 Aug. PMID 15233990

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neutrophil activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein kinase SYK
XP_038322533.1
XP_038322534.1
XP_038322535.1
XP_038322536.1
XP_038383232.1
XP_038383233.1
XP_038383234.1
XP_038383235.1
XP_038447537.1
XP_038447538.1
XP_038447539.1
XP_038447540.1
XP_038460677.1
XP_038460760.1
XP_038460843.1
XP_038460932.1
XP_038511337.1
XP_038511338.1
XP_038511339.1
XP_038511340.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    96507029..96590534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038655411.1 → XP_038511339.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Related
    ENSCAFP00845025386.1, ENSCAFT00845032468.1
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  2. XM_038655412.1 → XP_038511340.1  tyrosine-protein kinase SYK isoform X2

    UniProtKB/TrEMBL
    A0A8C0K179, A0A8I3PAZ0, A0A8P0N5A1
    Related
    ENSCAFP00845025321.1, ENSCAFT00845032390.1
    Conserved Domains (3) summary
    cd05116
    Location:351 → 606
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  3. XM_038655410.1 → XP_038511338.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  4. XM_038655409.1 → XP_038511337.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Related
    ENSCAFP00845025066.1, ENSCAFT00845032058.1
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    96134620..96217990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038466607.1 → XP_038322535.1  tyrosine-protein kinase SYK isoform X1

    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  2. XM_038466608.1 → XP_038322536.1  tyrosine-protein kinase SYK isoform X2

    Conserved Domains (3) summary
    cd05116
    Location:351 → 606
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  3. XM_038466606.1 → XP_038322534.1  tyrosine-protein kinase SYK isoform X1

    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  4. XM_038466605.1 → XP_038322533.1  tyrosine-protein kinase SYK isoform X1

    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    95855025..95938496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038591611.1 → XP_038447539.1  tyrosine-protein kinase SYK isoform X1

    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  2. XM_038591612.1 → XP_038447540.1  tyrosine-protein kinase SYK isoform X2

    Conserved Domains (3) summary
    cd05116
    Location:351 → 606
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  3. XM_038591610.1 → XP_038447538.1  tyrosine-protein kinase SYK isoform X1

    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  4. XM_038591609.1 → XP_038447537.1  tyrosine-protein kinase SYK isoform X1

    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    96615264..96698710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038527306.1 → XP_038383234.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  2. XM_038527307.1 → XP_038383235.1  tyrosine-protein kinase SYK isoform X2

    UniProtKB/TrEMBL
    A0A8C0K179, A0A8I3PAZ0, A0A8P0N5A1
    Conserved Domains (3) summary
    cd05116
    Location:351 → 606
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  3. XM_038527305.1 → XP_038383233.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  4. XM_038527304.1 → XP_038383232.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    96356719..96440184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038604915.1 → XP_038460843.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  2. XM_038605004.1 → XP_038460932.1  tyrosine-protein kinase SYK isoform X2

    UniProtKB/TrEMBL
    A0A8C0K179, A0A8I3PAZ0, A0A8P0N5A1
    Conserved Domains (3) summary
    cd05116
    Location:351 → 606
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  3. XM_038604832.1 → XP_038460760.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

  4. XM_038604749.1 → XP_038460677.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A8C0K1S5, A0A8I3P042, A0A8I3P3G0, A0A8P0SQ12, A0A8P0T739
    Conserved Domains (3) summary
    cd05116
    Location:374 → 629
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12 → 115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163 → 261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous