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JAK2 Janus kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 484185, updated on 11-Apr-2024

Summary

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Official Symbol
JAK2provided by VGNC
Official Full Name
Janus kinase 2provided by VGNC
Primary source
VGNC:VGNC:42176
See related
Ensembl:ENSCAFG00845015887
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (93940875..93989640)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (93730062..93844204)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (93996654..94110963)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (93507891..93622032)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (93232417..93346624)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096968 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC119881380 Neighboring gene 26S proteasome regulatory subunit 10B-like Neighboring gene insulin like 6 Neighboring gene CD274 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of JAK2 mutations in canine primary polycythemia. Beurlet S, et al. Exp Hematol, 2011 May. PMID 21320566
  2. Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma. Cletzer E, et al. Vet Immunol Immunopathol, 2020 Feb. PMID 31958674

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma.
    Title: Identification of the JAK-STAT pathway in canine splenic hemangiosarcoma, thyroid carcinoma, mast cell tumor, and anal sac adenocarcinoma.
  2. The mutations of the JAK2 gene occur in dogs, giving rise to a constitutively active JAK2 kinase, suggesting a common mechanism for canine diseases.
    Title: Identification of JAK2 mutations in canine primary polycythemia.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase JAK2
Names
Janus kinase 2 (a protein tyrosine kinase)
XP_022277546.1
XP_038322489.1
XP_038322490.1
XP_038322491.1
XP_038322492.1
XP_038322493.1
XP_038383187.1
XP_038383188.1
XP_038383189.1
XP_038383190.1
XP_038383191.1
XP_038447495.1
XP_038447496.1
XP_038447497.1
XP_038447498.1
XP_038447499.1
XP_038455636.1
XP_038455668.1
XP_038455686.1
XP_038511297.1
XP_038511298.1
XP_038511299.1
XP_541301.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    93940875..93989640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038655369.1 → XP_038511297.1  tyrosine-protein kinase JAK2 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NVH4
    Related
    ENSCAFP00845022298.1, ENSCAFT00845028345.1
    Conserved Domains (5) summary
    cd10379
    Location:237 → 332
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:117 → 237
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:396 → 657
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:695 → 978
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:1 → 112
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain

  2. XM_038655370.1 → XP_038511298.1  tyrosine-protein kinase JAK2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JUW0
    Conserved Domains (5) summary
    cd10379
    Location:237 → 332
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:117 → 237
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:396 → 657
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:1 → 112
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    cl21453
    Location:695 → 870
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038655371.1 → XP_038511299.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWM6
    Conserved Domains (3) summary
    cd10379
    Location:2 → 91
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd05078
    Location:155 → 416
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:454 → 737
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    93507891..93622032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038466561.1 → XP_038322489.1  tyrosine-protein kinase JAK2 isoform X4

    Conserved Domains (6) summary
    cd10379
    Location:386 → 481
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:844 → 1127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain

  2. XM_038466563.1 → XP_038322491.1  tyrosine-protein kinase JAK2 isoform X5

    Conserved Domains (6) summary
    cd10379
    Location:303 → 398
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:761 → 1044
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:60 → 178
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:1 → 51
    FERM_F1; FERM F1 ubiquitin-like domain

  3. XM_038466564.1 → XP_038322492.1  tyrosine-protein kinase JAK2 isoform X6

    Conserved Domains (6) summary
    cd10379
    Location:303 → 398
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:60 → 178
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:1 → 51
    FERM_F1; FERM F1 ubiquitin-like domain
    cl21453
    Location:761 → 936
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038466562.1 → XP_038322490.1  tyrosine-protein kinase JAK2 isoform X4

    Conserved Domains (6) summary
    cd10379
    Location:386 → 481
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:844 → 1127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain

  5. XM_038466565.1 → XP_038322493.1  tyrosine-protein kinase JAK2 isoform X1

    Conserved Domains (3) summary
    cd10379
    Location:2 → 91
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd05078
    Location:155 → 416
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:454 → 737
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    93232417..93346624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038591567.1 → XP_038447495.1  tyrosine-protein kinase JAK2 isoform X7

  2. XM_038591569.1 → XP_038447497.1  tyrosine-protein kinase JAK2 isoform X8

  3. XM_038591570.1 → XP_038447498.1  tyrosine-protein kinase JAK2 isoform X9

  4. XM_038591568.1 → XP_038447496.1  tyrosine-protein kinase JAK2 isoform X7

  5. XM_038591571.1 → XP_038447499.1  tyrosine-protein kinase JAK2 isoform X1

    Conserved Domains (3) summary
    cd10379
    Location:2 → 91
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd05078
    Location:155 → 416
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:454 → 737
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    93996654..94110963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038527259.1 → XP_038383187.1  tyrosine-protein kinase JAK2 isoform X10

    UniProtKB/TrEMBL
    A0A8C0JV87, A0A8C0N1P3

  2. XM_038527261.1 → XP_038383189.1  tyrosine-protein kinase JAK2 isoform X11

    UniProtKB/TrEMBL
    A0A8C0JXR2

  3. XM_038527262.1 → XP_038383190.1  tyrosine-protein kinase JAK2 isoform X12

    UniProtKB/TrEMBL
    A0A8C0JUW0

  4. XM_038527260.1 → XP_038383188.1  tyrosine-protein kinase JAK2 isoform X10

    UniProtKB/TrEMBL
    A0A8C0JV87, A0A8C0N1P3

  5. XM_038527263.1 → XP_038383191.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWM6
    Conserved Domains (3) summary
    cd10379
    Location:2 → 91
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd05078
    Location:155 → 416
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:454 → 737
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    93730062..93844204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022421838.2 → XP_022277546.1  tyrosine-protein kinase JAK2 isoform X13

    UniProtKB/TrEMBL
    A0A8C0JV87, A0A8C0QFW8, A0A8C0QV87, A0A8P0S800
    Conserved Domains (6) summary
    cd10379
    Location:386 → 481
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:844 → 1127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain

  2. XM_038599708.1 → XP_038455636.1  tyrosine-protein kinase JAK2 isoform X14

    UniProtKB/TrEMBL
    A0A8C0JXR2
    Conserved Domains (6) summary
    cd10379
    Location:303 → 398
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:761 → 1044
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:60 → 178
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:1 → 51
    FERM_F1; FERM F1 ubiquitin-like domain

  3. XM_038599740.1 → XP_038455668.1  tyrosine-protein kinase JAK2 isoform X15

    UniProtKB/TrEMBL
    A0A8C0JUW0
    Conserved Domains (6) summary
    cd10379
    Location:303 → 398
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:183 → 303
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:462 → 723
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:60 → 178
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:1 → 51
    FERM_F1; FERM F1 ubiquitin-like domain
    cl21453
    Location:761 → 936
    PKc_like; Protein Kinases, catalytic domain

  4. XM_541301.7 → XP_541301.2  tyrosine-protein kinase JAK2 isoform X13

    UniProtKB/TrEMBL
    A0A8C0JV87, A0A8C0QFW8, A0A8C0QV87, A0A8P0S800
    Conserved Domains (6) summary
    cd10379
    Location:386 → 481
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd13333
    Location:266 → 386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545 → 806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:844 → 1127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    pfam18377
    Location:143 → 261
    FERM_F2; FERM F2 acyl-CoA binding protein-like domain
    pfam18379
    Location:39 → 134
    FERM_F1; FERM F1 ubiquitin-like domain

  5. XM_038599758.1 → XP_038455686.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JWM6
    Conserved Domains (3) summary
    cd10379
    Location:2 → 91
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    cd05078
    Location:155 → 416
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:454 → 737
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
Nucleotide Protein
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