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CHRM1 cholinergic receptor muscarinic 1 [ Canis lupus familiaris (dog) ]

Gene ID: 483776, updated on 5-Mar-2024

Summary

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Official Symbol
CHRM1provided by VGNC
Official Full Name
cholinergic receptor muscarinic 1provided by VGNC
Primary source
VGNC:VGNC:39231
See related
Ensembl:ENSCAFG00845007309
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (54835906..54849703)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (52389834..52403632)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (54299342..54313140)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (53933197..53947176)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (53507453..53521228)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102157191 Neighboring gene solute carrier family 22 member 8 Neighboring gene solute carrier family 22 member 6 Neighboring gene uncharacterized LOC119864276 Neighboring gene solute carrier family 3 member 2 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caveolin 2 regulates endocytosis and trafficking of the M1 muscarinic receptor in MDCK epithelial cells. Shmuel M, et al. Mol Biol Cell, 2007 May. PMID 17314410, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. caveolins play a role in the attenuation of the M1 muscarinic receptor's intracellular trafficking to and from the plasma membrane
    Title: Caveolin 2 regulates endocytosis and trafficking of the M1 muscarinic receptor in MDCK epithelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cognition IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of locomotion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in saliva secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
muscarinic acetylcholine receptor M1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    54835906..54849703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038425262.1 → XP_038281190.1  muscarinic acetylcholine receptor M1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
    Related
    ENSCAFP00845010054.1, ENSCAFT00845012901.1
    Conserved Domains (1) summary
    cd17790
    Location:26 → 429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_038425263.1 → XP_038281191.1  muscarinic acetylcholine receptor M1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
    Related
    ENSCAFP00845010076.1, ENSCAFT00845012926.1
    Conserved Domains (1) summary
    cd17790
    Location:26 → 429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    53933197..53947176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038501531.1 → XP_038357459.1  muscarinic acetylcholine receptor M1 isoform X1

    Conserved Domains (1) summary
    cd17790
    Location:26 → 429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_038501530.1 → XP_038357458.1  muscarinic acetylcholine receptor M1 isoform X2

    Conserved Domains (1) summary
    cd17790
    Location:246 → 649
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    53507453..53521228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038628358.1 → XP_038484286.1  LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    54299342..54313140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038564218.1 → XP_038420146.1  muscarinic acetylcholine receptor M1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
    Conserved Domains (1) summary
    cd17790
    Location:26 → 429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_038564217.1 → XP_038420145.1  muscarinic acetylcholine receptor M1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0T0L4, A0A8P0TT19
    Conserved Domains (1) summary
    cd17790
    Location:246 → 649
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    52389834..52403632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005631597.3 → XP_005631654.1  muscarinic acetylcholine receptor M1 isoform X1

    See identical proteins and their annotated locations for XP_005631654.1

    UniProtKB/TrEMBL
    A0A8C0MJA7, A0A8C0R0G3, A0A8I3RVA9
    Conserved Domains (1) summary
    cd17790
    Location:26 → 429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_540897.6 → XP_540897.3  muscarinic acetylcholine receptor M1 isoform X4

    UniProtKB/TrEMBL
    A0A8C0T0L4, A0A8P0TT19
    Conserved Domains (1) summary
    cd17790
    Location:246 → 649
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein
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