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CAPN1 calpain 1 [ Canis lupus familiaris (dog) ]

Gene ID: 483745, updated on 5-Mar-2024

Summary

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Official Symbol
CAPN1provided by VGNC
Official Full Name
calpain 1provided by VGNC
Primary source
VGNC:VGNC:38698
See related
Ensembl:ENSCAFG00845025353
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (53024769..53053236, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (50591530..50619992, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (52489182..52517646, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (52121242..52149446, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (51694854..51723087, complement)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 20-like Neighboring gene solute carrier family 22 member 20 Neighboring gene speedy/RINGO cell cycle regulator family member C Neighboring gene synoviolin 1 Neighboring gene mitochondrial ribosomal protein L49

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed. Forman OP, et al. PLoS One, 2013. PMID 23741357, Free PMC Article
  2. [Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy]. Sang Y, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2011 May. PMID 21781600

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed.
    Title: Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed.
  2. Valsartan and carnitine could reduce alcoholic cardiomyopathy by downregulating Calpain-1 and Bad protein expression and upregulating expression of Bcl-xl protein.
    Title: [Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy].
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-1 catalytic subunit
XP_038280961.1
XP_038280962.1
XP_038309787.1
XP_038309788.1
XP_038357225.1
XP_038357226.1
XP_038419901.1
XP_038419902.1
XP_038484032.1
XP_038484033.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    53024769..53053236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038425034.1 → XP_038280962.1  calpain-1 catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0KQ28, A0A8C0T891, A0A8I3S5B6, A0A8I3S9F9, A0A8P0PJX1
    Related
    ENSCAFP00845035330.1, ENSCAFT00845045068.1
    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038425033.1 → XP_038280961.1  calpain-1 catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0KQ28, A0A8C0T891, A0A8I3S5B6, A0A8I3S9F9, A0A8P0PJX1
    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    52121242..52149446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038501298.1 → XP_038357226.1  calpain-1 catalytic subunit

    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038501297.1 → XP_038357225.1  calpain-1 catalytic subunit

    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    51694854..51723087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038628105.1 → XP_038484033.1  calpain-1 catalytic subunit

    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038628104.1 → XP_038484032.1  calpain-1 catalytic subunit

    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    52489182..52517646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038563974.1 → XP_038419902.1  calpain-1 catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0KQ28, A0A8C0T891, A0A8I3S5B6, A0A8I3S9F9, A0A8P0PJX1
    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038563973.1 → XP_038419901.1  calpain-1 catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0KQ28, A0A8C0T891, A0A8I3S5B6, A0A8I3S9F9, A0A8P0PJX1
    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    50591530..50619992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038453860.1 → XP_038309788.1  calpain-1 catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0KQ28, A0A8C0T891, A0A8I3S5B6, A0A8I3S9F9, A0A8P0PJX1
    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease

  2. XM_038453859.1 → XP_038309787.1  calpain-1 catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0KQ28, A0A8C0T891, A0A8I3S5B6, A0A8I3S9F9, A0A8P0PJX1
    Conserved Domains (3) summary
    cd00214
    Location:364 → 525
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16198
    Location:547 → 715
    EFh_PEF_CAPN1; Penta-EF hand, calcium binding motifs, found in mu-type calpain (CAPN1)
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease
Nucleotide Protein
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