FOSL1 FOS like 1, AP-1 transcription factor subunit [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: FOSL1provided by VGNC
Official Full Name: FOS like 1, AP-1 transcription factor subunitprovided by VGNC
Primary source: VGNC:VGNC:40942
See related: Ensembl:ENSCAFG00845017398
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (52404801..52412502)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (49975212..49982921)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (51868548..51876244)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (51504866..51512571)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (51079242..51086930)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we show that oncogenic K-Ras(V12) upregulates alpha6-integrin expression in Madin-Darby canine kidney (MDCK) cells via activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK)/Fos-related antigen 1-signaling cascade.
Title: Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT.

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fos-related antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051822.1 Reference ROS_Cfam_1.0

Range

52404801..52412502

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038424938.1 → XP_038280866.1 fos-related antigen 1

UniProtKB/TrEMBL

A0A8C0KSF6, A0A8C0YZ21, A0A8I3P2C8

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
XM_038424939.1 → XP_038280867.1 fos-related antigen 1

UniProtKB/TrEMBL

A0A8C0KSF6, A0A8C0YZ21, A0A8I3P2C8

Related

ENSCAFP00845024164.1, ENSCAFT00845030824.1

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

Alternate UMICH_Zoey_3.1

Genomic

NC_049278.1 Alternate UMICH_Zoey_3.1

Range

51504866..51512571

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038501177.1 → XP_038357105.1 fos-related antigen 1

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
XM_038501178.1 → XP_038357106.1 fos-related antigen 1

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049759.1 Alternate UNSW_CanFamBas_1.0

Range

51079242..51086930

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038628004.1 → XP_038483932.1 fos-related antigen 1

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
XM_038628005.1 → XP_038483933.1 fos-related antigen 1

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049239.1 Alternate UU_Cfam_GSD_1.0

Range

51868548..51876244

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038563878.1 → XP_038419806.1 fos-related antigen 1

UniProtKB/TrEMBL

A0A8C0KSF6, A0A8C0YZ21, A0A8I3P2C8

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
XM_038563879.1 → XP_038419807.1 fos-related antigen 1

UniProtKB/TrEMBL

A0A8C0KSF6, A0A8C0YZ21, A0A8I3P2C8

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

49975212..49982921

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022405633.2 → XP_022261341.1 fos-related antigen 1

UniProtKB/TrEMBL

A0A8C0KSF6, A0A8C0YZ21, A0A8I3P2C8

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
XM_540845.7 → XP_540845.3 fos-related antigen 1

See identical proteins and their annotated locations for XP_540845.3

UniProtKB/TrEMBL

A0A8C0KSF6, A0A8C0YZ21, A0A8I3P2C8

Conserved Domains (2) summary

cd14721
Location:112 → 165

bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

cl28929
Location:126 → 240

VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)