PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PIK3CGprovided by VGNC
Official Full Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gammaprovided by VGNC
Primary source: VGNC:VGNC:44558
See related: Ensembl:ENSCAFG00845026701
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	18	NC_051822.1 (13848210..13882893, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	18	NC_006600.4 (13224877..13259686, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	18	NC_049239.1 (13862587..13897681, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	18	NC_049278.1 (13664384..13696319, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	18	NC_049759.1 (13582574..13617381, complement)

Chromosome 18 - NC_051822.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PI3-kinase exerts a major morphogenetic impact in simple cultured epithelia through preservation of cell height.
Title: Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers.

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IA	IEA Inferred from Electronic Annotation more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class IB	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Names: phosphoinositide-3-kinase, catalytic, gamma polypeptide

XP_005631016.1

EC 2.7.1.153

XP_038279729.1

EC 2.7.1.153

XP_038279730.1

EC 2.7.1.153

XP_038279731.1

EC 2.7.1.153

XP_038309923.1

EC 2.7.1.153

XP_038356086.1

EC 2.7.1.153

XP_038418642.1

EC 2.7.1.153

XP_038418643.1

EC 2.7.1.153

XP_038418644.1

EC 2.7.1.153

XP_038482750.1

EC 2.7.1.153

XP_038482751.1

EC 2.7.1.153

XP_038482752.1

EC 2.7.1.153

XP_540385.2

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051822.1 Reference ROS_Cfam_1.0

Range

13848210..13882893 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038423802.1 → XP_038279730.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

UniProtKB/TrEMBL

A0A8C0SKE3, A0A8I3S601

Related

ENSCAFP00845036928.1, ENSCAFT00845047056.1

Conserved Domains (4) summary

cd08399
Location:350 → 529

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:551 → 727

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:731 → 1097

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_038423801.1 → XP_038279729.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

UniProtKB/TrEMBL

A0A8C0SKE3

Conserved Domains (4) summary

cd08399
Location:378 → 557

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:231 → 340

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:579 → 755

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:759 → 1125

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_038423803.1 → XP_038279731.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

UniProtKB/TrEMBL

A0A8C0SKE3, A0A8I3S601

Conserved Domains (4) summary

cd08399
Location:350 → 529

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:551 → 727

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:731 → 1097

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma

Alternate UMICH_Zoey_3.1

Genomic

NC_049278.1 Alternate UMICH_Zoey_3.1

Range

13664384..13696319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038500158.1 → XP_038356086.1 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049759.1 Alternate UNSW_CanFamBas_1.0

Range

13582574..13617381 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038626823.1 → XP_038482751.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2
XM_038626822.1 → XP_038482750.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

Conserved Domains (4) summary

cd08399
Location:378 → 557

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:231 → 340

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:579 → 755

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:759 → 1125

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_038626824.1 → XP_038482752.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049239.1 Alternate UU_Cfam_GSD_1.0

Range

13862587..13897681 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038562715.1 → XP_038418643.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

UniProtKB/TrEMBL

A0A8C0RPI8, A0A8C0SKE3, A0A8P0PAL1
XM_038562714.1 → XP_038418642.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

UniProtKB/TrEMBL

A0A8C0SKE3
XM_038562716.1 → XP_038418644.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

UniProtKB/TrEMBL

A0A8C0RPI8, A0A8C0SKE3, A0A8P0PAL1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

13224877..13259686 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005630959.4 → XP_005631016.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

See identical proteins and their annotated locations for XP_005631016.1

UniProtKB/TrEMBL

A0A8C0RPI8, A0A8C0SKE3, A0A8P0PAL1

Conserved Domains (4) summary

cd08399
Location:350 → 529

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:551 → 727

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:731 → 1097

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_038453995.1 → XP_038309923.1 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1

UniProtKB/TrEMBL

A0A8C0SKE3

Conserved Domains (4) summary

cd08399
Location:378 → 557

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:231 → 340

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:579 → 755

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:759 → 1125

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma
XM_540385.6 → XP_540385.2 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2

See identical proteins and their annotated locations for XP_540385.2

UniProtKB/TrEMBL

A0A8C0RPI8, A0A8C0SKE3, A0A8P0PAL1

Conserved Domains (4) summary

cd08399
Location:350 → 529

C2_PI3K_class_I_gamma; C2 domain present in class I gamma phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:203 → 312

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00872
Location:551 → 727

PI3Ka_I; Phosphoinositide 3-kinase (PI3K) class I, accessory domain ; PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3K class I prefer phosphoinositol (4,5) ...

cd00894
Location:731 → 1097

PI3Kc_IB_gamma; Catalytic domain of Class IB Phosphoinositide 3-kinase gamma