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NOTCH2 notch receptor 2 [ Canis lupus familiaris (dog) ]

Gene ID: 483148, updated on 5-Mar-2024

Summary

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Gene symbol
NOTCH2
Gene description
notch receptor 2
See related
Ensembl:ENSCAFG00845007331
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
36
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (57717260..57900443, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (56476088..56659161, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (57426245..57608931, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (56764520..56924479, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (56800478..56960572, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene regenerating islet-derived protein 4 Neighboring gene disintegrin and metalloproteinase domain-containing protein 30 Neighboring gene D-3-phosphoglycerate dehydrogenase Neighboring gene uncharacterized LOC119863971 Neighboring gene hydroxymethylglutaryl-CoA synthase, mitochondrial-like Neighboring gene ubiquitin-conjugating enzyme E2 D3-like Neighboring gene uncharacterized LOC102154106 Neighboring gene uncharacterized LOC111090694 Neighboring gene histone H2B type 2-E1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to tumor cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurogenic locus notch homolog protein 2
Names
Notch homolog 2
notch 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    57717260..57900443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038422869.1 → XP_038278797.1  neurogenic locus notch homolog protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SR20
    Related
    ENSCAFP00845010265.1, ENSCAFT00845013210.1
    Conserved Domains (11) summary
    smart00004
    Location:1421 → 1455
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1879 → 2066
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:182 → 218
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1943 → 1974
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1505 → 1534
    Notch; LNR domain
    pfam03154
    Location:2273 → 2467
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1540 → 1594
    NOD; NOTCH protein
    pfam07684
    Location:1619 → 1674
    NODP; NOTCH protein
    pfam11936
    Location:2381 → 2444
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1948 → 2040
    Ank_2; Ankyrin repeats (3 copies)
    cd21703
    Location:1659 → 1740
    JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    56764520..56924479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038499365.1 → XP_038355293.1  neurogenic locus notch homolog protein 2 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    56800478..56960572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038626003.1 → XP_038481931.1  neurogenic locus notch homolog protein 2 isoform X1

    Conserved Domains (11) summary
    smart00004
    Location:1421 → 1455
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1879 → 2066
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:182 → 218
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1943 → 1974
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1505 → 1534
    Notch; LNR domain
    pfam03154
    Location:2273 → 2467
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1540 → 1594
    NOD; NOTCH protein
    pfam07684
    Location:1619 → 1674
    NODP; NOTCH protein
    pfam11936
    Location:2381 → 2444
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1948 → 2040
    Ank_2; Ankyrin repeats (3 copies)
    cd21703
    Location:1659 → 1740
    JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    57426245..57608931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038561934.1 → XP_038417862.1  neurogenic locus notch homolog protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SR20
    Conserved Domains (11) summary
    smart00004
    Location:1421 → 1455
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1879 → 2066
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:182 → 218
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1943 → 1974
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1505 → 1534
    Notch; LNR domain
    pfam03154
    Location:2273 → 2467
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1540 → 1594
    NOD; NOTCH protein
    pfam07684
    Location:1619 → 1674
    NODP; NOTCH protein
    pfam11936
    Location:2381 → 2444
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1948 → 2040
    Ank_2; Ankyrin repeats (3 copies)
    cd21703
    Location:1659 → 1740
    JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    56476088..56659161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005630688.4 → XP_005630745.1  neurogenic locus notch homolog protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SR20
    Conserved Domains (11) summary
    smart00004
    Location:1421 → 1455
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1879 → 2066
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:182 → 218
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1943 → 1974
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1505 → 1534
    Notch; LNR domain
    pfam03154
    Location:2273 → 2467
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1540 → 1594
    NOD; NOTCH protein
    pfam07684
    Location:1619 → 1674
    NODP; NOTCH protein
    pfam11936
    Location:2381 → 2444
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1948 → 2040
    Ank_2; Ankyrin repeats (3 copies)
    cd21703
    Location:1659 → 1740
    JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins
Nucleotide Protein
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