KDR kinase insert domain receptor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: KDRprovided by VGNC
Official Full Name: kinase insert domain receptorprovided by VGNC
Primary source: VGNC:VGNC:42331
See related: Ensembl:ENSCAFG00845012083
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: flk-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	13	NC_051817.1 (48053730..48095387, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	13	NC_006595.4 (47400610..47442293, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	13	NC_049234.1 (48206381..48248022, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	13	NC_049273.1 (47729487..47771112, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	13	NC_049754.1 (47258117..47299735, complement)

Chromosome 13 - NC_051817.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evaluation of ponatinib in vitro effect in three canine mast cell tumor cell lines expressing FGFR-1, PDGFR-alpha, and VEGFR-2.
Title: Evaluation of ponatinib in vitro effect in three canine mast cell tumor cell lines expressing FGFR-1, PDGFR-α, and VEGFR-2.
Both VEGF and VEGFR-2 immunoreactivities were independent of patients' overall survival (OS) and disease-free survival (DFS).
Title: VEGFR-2 expression in malignant tumours of the canine mammary gland: a prospective survival study.
The results of this study suggest a role for VEGF receptors in both physiologic and pathologic angiogenesis in canine ocular tissue.
Title: Expression of vascular endothelial growth factor receptor-1 and -2 in normal and diseased canine eyes.
decreased VEGFR-2 levels in frontal cortex may be contributed to decreased CBF and increased ventricular cerebrospinal fluid VEGF levels
Title: VEGF/VEGFR-2 changes in frontal cortex, choroid plexus, and CSF after chronic obstructive hydrocephalus.
Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (VEGFR-2), may promote tumor cell proliferation in trichoepitheliomas and squamous cell carcinomas.
Title: Immunohistochemical expression of vascular endothelial growth factor and vascular endothelial growth factor receptor associated with tumor cell proliferation in canine cutaneous squamous cell carcinomas and trichoepitheliomas.
Expression of vascular endothelial growth factor (VEGF), its receptors (flt-1, flg-1 and flk-1), and basic fibroblast growth factor (bFGF) in canine hemangiosarcoma (HSA) and hemangiomas was investigated by immunohistochemical analysis
Title: Expression of vascular endothelial growth factor, basic fibroblast growth factor, and their receptors (flt-1, flk-1, and flg-1) in canine vascular tumors.

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General gene information

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Markers

Kdr (e-PCR), detects polymorphism
- UniSTS:498724

KDR (e-PCR)
- UniSTS:264084

GDB:626090 (e-PCR)
- UniSTS:158389

KDR (e-PCR)
- UniSTS:503486

MARC_52618-52619:1146767096:2 (e-PCR)
- UniSTS:508103

Kdr (e-PCR), detects polymorphism
- UniSTS:275687

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endothelial cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vascular endothelial growth factor receptor 2

Names: VEGFR2; kinase insert domain receptor (a type III receptor tyrosine kinase)

NP_001041489.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048024.1 → NP_001041489.1 vascular endothelial growth factor receptor 2 precursor

See identical proteins and their annotated locations for NP_001041489.1

Status: PROVISIONAL

Source sequence(s)

DQ269018

UniProtKB/TrEMBL

A0A8C0NTB4, A0A8C0P2Y2, A0A8I3NAH2, Q2XPT7

Related

ENSCAFP00845016889.1, ENSCAFT00845021490.1

Conserved Domains (7) summary

smart00410
Location:564 → 660

IG_like; Immunoglobulin like

cd05103
Location:825 → 1166

PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2

pfam17988
Location:758 → 792

VEGFR-2_TMD; VEGFR-2 Transmembrane domain

pfam07679
Location:666 → 753

I-set; Immunoglobulin I-set domain

cd00096
Location:683 → 687

Ig; Ig strand B [structural motif]

cd05862
Location:224 → 326

IgI_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains

cd05864
Location:329 → 417

IgI_VEGFR-2; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2); member of the I-set of Ig superfamily (IgSF) domains