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MCM3 minichromosome maintenance complex component 3 [ Canis lupus familiaris (dog) ]

Gene ID: 481839, updated on 5-Mar-2024

Summary

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Official Symbol
MCM3provided by VGNC
Official Full Name
minichromosome maintenance complex component 3provided by VGNC
Primary source
VGNC:VGNC:43082
See related
Ensembl:ENSCAFG00845008858
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (20422999..20444648, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (19821166..19842529, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (20170450..20191818, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (19928809..19950166, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (20031993..20053341, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene quinone oxidoreductase-like Neighboring gene interleukin 17F Neighboring gene progestin and adipoQ receptor family member 8 Neighboring gene uncharacterized LOC119881674 Neighboring gene EF-hand domain containing 1 Neighboring gene uncharacterized LOC119874180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Correlation between MCM-3 protein expression and grade of malignancy in mammary adenocarcinomas and soft tissue fibrosarcomas in dogs. Nowak M, et al. In Vivo, 2009 Jan-Feb. PMID 19368124

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MCM-3 may provide a sensitive and useful marker of proliferative potential in various histological types of neoplastic tumours.
    Title: Correlation between MCM-3 protein expression and grade of malignancy in mammary adenocarcinomas and soft tissue fibrosarcomas in dogs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA strand elongation involved in DNA replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA replication licensing factor MCM3
XP_038347964.1
XP_038410229.1
XP_038474092.1
XP_038539681.1
XP_538960.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    20422999..20444648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683753.1 → XP_038539681.1  DNA replication licensing factor MCM3

    UniProtKB/TrEMBL
    A0A8C0KK39, A0A8C0NR04
    Related
    ENSCAFP00845012219.1, ENSCAFT00845015709.1
    Conserved Domains (2) summary
    smart00350
    Location:109 → 654
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16 → 102
    MCM_N; MCM N-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    19928809..19950166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492036.1 → XP_038347964.1  DNA replication licensing factor MCM3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    20031993..20053341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618164.1 → XP_038474092.1  DNA replication licensing factor MCM3

    Conserved Domains (2) summary
    smart00350
    Location:109 → 654
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16 → 102
    MCM_N; MCM N-terminal domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    20170450..20191818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038554301.1 → XP_038410229.1  DNA replication licensing factor MCM3

    UniProtKB/TrEMBL
    A0A8C0KK39, A0A8C0NR04
    Conserved Domains (2) summary
    smart00350
    Location:109 → 654
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16 → 102
    MCM_N; MCM N-terminal domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    19821166..19842529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_538960.7 → XP_538960.3  DNA replication licensing factor MCM3

    UniProtKB/TrEMBL
    A0A8C0KK39, A0A8C0NR04
    Conserved Domains (2) summary
    smart00350
    Location:109 → 654
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16 → 102
    MCM_N; MCM N-terminal domain
Nucleotide Protein
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