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DLA-DRA MHC class II DR alpha chain [ Canis lupus familiaris (dog) ]

Gene ID: 481731, updated on 5-Mar-2024

Summary

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Gene symbol
DLA-DRA
Gene description
MHC class II DR alpha chain
See related
Ensembl:ENSCAFG00845017467
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
DLA-DRA1
Orthologs
human all
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Genomic context

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Location:
chromosome: 12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (2409388..2414180)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (2282352..2285906)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (2287866..2291417)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (2132677..2136225)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (2213826..2217378)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase FKBP1A-like Neighboring gene butyrophilin like 2 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene uncharacterized LOC119874143 Neighboring gene 60S ribosomal protein L7a-like Neighboring gene MHC class II DLA DRB1 beta chain Neighboring gene major histocompatibility complex, class II, DQ alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence and polymorphism analysis of canine DRA cDNA clones. Wagner JL, et al. Tissue Antigens, 1995 Apr. PMID 7638867
  2. Genomic sequence of the class II region of the canine MHC: comparison with the MHC of other mammalian species. Debenham SL, et al. Genomics, 2005 Jan. PMID 15607421

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptide antigen assembly with MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
MHC class II DR alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011723.1 → NP_001011723.1  MHC class II DR alpha chain precursor

    See identical proteins and their annotated locations for NP_001011723.1

    Status: PROVISIONAL

    Source sequence(s)
    L37332
    UniProtKB/TrEMBL
    A0A8C0JK13, A0A8C0RKX0, A0A8C0T6C8, F1PLW1, Q30437
    Conserved Domains (3) summary
    pfam00993
    Location:29 → 108
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cd00096
    Location:111 → 119
    Ig; Ig strand A [structural motif]
    cl11960
    Location:110 → 204
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    2409388..2414180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038682742.1 → XP_038538670.1  MHC class II DR alpha chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0JK13, A0A8C0RKX0, A0A8C0T6C8, F1PLW1, Q30437
    Related
    ENSCAFP00845024273.1, ENSCAFT00845030976.1
    Conserved Domains (3) summary
    pfam00993
    Location:29 → 108
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cd00096
    Location:111 → 119
    Ig; Ig strand A [structural motif]
    cl11960
    Location:110 → 204
    Ig; Immunoglobulin domain

  2. XM_038682741.1 → XP_038538669.1  MHC class II DR alpha chain isoform X1

    UniProtKB/TrEMBL
    A0A8C0JK13, A0A8C0RKX0, A0A8C0T6C8, F1PLW1, Q30437
    Related
    ENSCAFP00845024244.1, ENSCAFT00845030935.1
    Conserved Domains (3) summary
    pfam00993
    Location:29 → 108
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    cd00096
    Location:111 → 119
    Ig; Ig strand A [structural motif]
    cl11960
    Location:110 → 204
    Ig; Immunoglobulin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    2132677..2136225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    2213826..2217378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    2287866..2291417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    2282352..2285906
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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