U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NOTCH4 notch receptor 4 [ Canis lupus familiaris (dog) ]

Gene ID: 481726, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
NOTCH4provided by VGNC
Official Full Name
notch receptor 4provided by VGNC
Primary source
VGNC:VGNC:43900
See related
Ensembl:ENSCAFG00845016542
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 12
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (1724977..1746984, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (1720443..1742455, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (1719919..1741905, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (1587999..1609976, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (1653597..1675505, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene butyrophilin-like protein 1 Neighboring gene ring finger protein 5 Neighboring gene PBX homeobox 2 Neighboring gene G protein signaling modulator 3 Neighboring gene glutamic acid-rich protein-like Neighboring gene thymosin beta 4, X-linked pseudogene Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
neurogenic locus notch homolog protein 4; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4
Names
Notch homolog 4
notch 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    1724977..1746984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038683077.1 → XP_038539005.1  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NLH1
    Related
    ENSCAFT00845029482.1
    Conserved Domains (11) summary
    smart00004
    Location:1198 → 1236
    NL; Domain found in Notch and Lin-12
    PHA03095
    Location:1567 → 1818
    PHA03095; ankyrin-like protein; Provisional
    cd00054
    Location:545 → 581
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1622 → 1652
    ANK; ANK repeat [structural motif]
    pfam00008
    Location:724 → 754
    EGF; EGF-like domain
    pfam00066
    Location:1246 → 1275
    Notch; LNR domain
    pfam06816
    Location:1286 → 1335
    NOD; NOTCH protein
    pfam07684
    Location:1370 → 1425
    NODP; NOTCH protein
    pfam12796
    Location:1626 → 1719
    Ank_2; Ankyrin repeats (3 copies)
    cl02419
    Location:1154 → 1194
    Notch; LNR domain
    cl41775
    Location:1416 → 1506
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    1587999..1609976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038491421.1 → XP_038347349.1  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    1653597..1675505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038617515.1 → XP_038473443.1  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4 isoform X1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    1719919..1741905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038553640.1 → XP_038409568.1  neurogenic locus notch homolog protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0NLH1

  2. XM_038553641.1 → XP_038409569.1  neurogenic locus notch homolog protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NLH1

  3. XM_038553639.1 → XP_038409567.1  neurogenic locus notch homolog protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NLH1

  4. XM_038553638.1 → XP_038409566.1  neurogenic locus notch homolog protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NLH1

  5. XM_038553642.1 → XP_038409570.1  neurogenic locus notch homolog protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0NLH1

  6. XM_038553643.1 → XP_038409571.1  neurogenic locus notch homolog protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0NLH1

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1720443..1742455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038675223.1 → XP_038531151.1  neurogenic locus notch homolog protein 4 isoform X7

    UniProtKB/TrEMBL
    A0A8C0NLH1
    Conserved Domains (11) summary
    smart00004
    Location:1094 → 1132
    NL; Domain found in Notch and Lin-12
    PHA03095
    Location:1463 → 1711
    PHA03095; ankyrin-like protein; Provisional
    cd00054
    Location:441 → 477
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1518 → 1548
    ANK; ANK repeat [structural motif]
    pfam00008
    Location:620 → 650
    EGF; EGF-like domain
    pfam00066
    Location:1142 → 1171
    Notch; LNR domain
    pfam06816
    Location:1182 → 1231
    NOD; NOTCH protein
    pfam07684
    Location:1266 → 1321
    NODP; NOTCH protein
    pfam12796
    Location:1522 → 1615
    Ank_2; Ankyrin repeats (3 copies)
    cl02419
    Location:1050 → 1090
    Notch; LNR domain
    cl41775
    Location:1312 → 1402
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  2. XM_038675227.1 → XP_038531155.1  neurogenic locus notch homolog protein 4 isoform X8

    UniProtKB/TrEMBL
    A0A8C0NLH1, A0A8P0PLS3
    Conserved Domains (11) summary
    smart00004
    Location:1082 → 1120
    NL; Domain found in Notch and Lin-12
    PHA03095
    Location:1451 → 1699
    PHA03095; ankyrin-like protein; Provisional
    cd00054
    Location:429 → 465
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1506 → 1536
    ANK; ANK repeat [structural motif]
    pfam00008
    Location:608 → 638
    EGF; EGF-like domain
    pfam00066
    Location:1130 → 1159
    Notch; LNR domain
    pfam06816
    Location:1170 → 1219
    NOD; NOTCH protein
    pfam07684
    Location:1254 → 1309
    NODP; NOTCH protein
    pfam12796
    Location:1510 → 1603
    Ank_2; Ankyrin repeats (3 copies)
    cl02419
    Location:1038 → 1078
    Notch; LNR domain
    cl41775
    Location:1300 → 1390
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  3. XM_038675220.1 → XP_038531148.1  neurogenic locus notch homolog protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A8C0NLH1
    Conserved Domains (11) summary
    smart00004
    Location:1195 → 1233
    NL; Domain found in Notch and Lin-12
    PHA03095
    Location:1564 → 1812
    PHA03095; ankyrin-like protein; Provisional
    cd00054
    Location:542 → 578
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1619 → 1649
    ANK; ANK repeat [structural motif]
    pfam00008
    Location:721 → 751
    EGF; EGF-like domain
    pfam00066
    Location:1243 → 1272
    Notch; LNR domain
    pfam06816
    Location:1283 → 1332
    NOD; NOTCH protein
    pfam07684
    Location:1367 → 1422
    NODP; NOTCH protein
    pfam12796
    Location:1623 → 1716
    Ank_2; Ankyrin repeats (3 copies)
    cl02419
    Location:1151 → 1191
    Notch; LNR domain
    cl41775
    Location:1413 → 1503
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  4. XM_038675216.1 → XP_038531144.1  neurogenic locus notch homolog protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NLH1
    Conserved Domains (11) summary
    smart00004
    Location:1198 → 1236
    NL; Domain found in Notch and Lin-12
    PHA03095
    Location:1567 → 1815
    PHA03095; ankyrin-like protein; Provisional
    cd00054
    Location:545 → 581
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1622 → 1652
    ANK; ANK repeat [structural motif]
    pfam00008
    Location:724 → 754
    EGF; EGF-like domain
    pfam00066
    Location:1246 → 1275
    Notch; LNR domain
    pfam06816
    Location:1286 → 1335
    NOD; NOTCH protein
    pfam07684
    Location:1370 → 1425
    NODP; NOTCH protein
    pfam12796
    Location:1626 → 1719
    Ank_2; Ankyrin repeats (3 copies)
    cl02419
    Location:1154 → 1194
    Notch; LNR domain
    cl41775
    Location:1416 → 1506
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  5. XM_038675232.1 → XP_038531160.1  neurogenic locus notch homolog protein 4 isoform X9

    UniProtKB/TrEMBL
    A0A8C0NLH1
    Conserved Domains (10) summary
    smart00004
    Location:1198 → 1236
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1566 → 1670
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:545 → 581
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1574 → 1618
    ANK; ANK repeat [structural motif]
    pfam00008
    Location:724 → 754
    EGF; EGF-like domain
    pfam00066
    Location:1246 → 1275
    Notch; LNR domain
    pfam06816
    Location:1286 → 1335
    NOD; NOTCH protein
    pfam07684
    Location:1370 → 1425
    NODP; NOTCH protein
    cl02419
    Location:1154 → 1194
    Notch; LNR domain
    cl41775
    Location:1416 → 1506
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

  6. XM_038675239.1 → XP_038531167.1  neurogenic locus notch homolog protein 4 isoform X9

    UniProtKB/TrEMBL
    A0A8C0NLH1
    Conserved Domains (10) summary
    smart00004
    Location:1198 → 1236
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1566 → 1670
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:545 → 581
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1574 → 1618
    ANK; ANK repeat [structural motif]
    pfam00008
    Location:724 → 754
    EGF; EGF-like domain
    pfam00066
    Location:1246 → 1275
    Notch; LNR domain
    pfam06816
    Location:1286 → 1335
    NOD; NOTCH protein
    pfam07684
    Location:1370 → 1425
    NODP; NOTCH protein
    cl02419
    Location:1154 → 1194
    Notch; LNR domain
    cl41775
    Location:1416 → 1506
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous