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LOC481709 POU domain, class 5, transcription factor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 481709, updated on 22-Jan-2024

Summary

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Gene symbol
LOC481709
Gene description
POU domain, class 5, transcription factor 1
See related
Ensembl:ENSCAFG00845017478
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
OCT4
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Genomic context

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See LOC481709 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (86365..91333)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (998319..1003284, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (1000755..1005716, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (864674..869639, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (932964..937930, complement)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152528 Neighboring gene uncharacterized LOC119874136 Neighboring gene transcription factor 19 Neighboring gene coiled-coil alpha-helical rod protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours. Vargas TH, et al. J Comp Pathol, 2015 Nov. PMID 26460092
  2. Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia. Webster JD, et al. Vet Pathol, 2007 Nov. PMID 18039902
  3. Domestic carnivore's development: detection of Oct-4, a pluripotency marker, in pharyngeal arches. Roballo KC, et al. Reprod Domest Anim, 2013 Jun. PMID 23379423
  4. Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair. Erwin WM, et al. Spine (Phila Pa 1976), 2013 Feb 1. PMID 22772571

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. suggest that OCT4 expression is not a precise prognostic indicator for canine mast cell tumour
    Title: Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours.
  2. The expression of Oct4 in the pharyngeal arches of dog and cat embryos aged 17-25 days is reported.
    Title: Domestic carnivore's development: detection of Oct-4, a pluripotency marker, in pharyngeal arches.
  3. Data indicate that intervertebral disc (IVD)-derived stem/progenitor cells express Oct3/4, Sox2, CD133 (PROM1), Nanog, and Nestin.
    Title: Intervertebral disc-derived stem cells: implications for regenerative medicine and neural repair.
  4. This study evaluated the hypothesis that octamer transcription factor 4 (Oct4)-positive cells are present in all canine neoplasms and that these subpopulations of neoplastic cells might represent "cancer stem" cells.
    Title: Expression of the embryonic transcription factor Oct4 in canine neoplasms: a potential marker for stem cell subpopulations in neoplasia.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
POU domain, class 5, transcription factor 1; LOW QUALITY PROTEIN: POU domain, class 5, transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    86365..91333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038682857.1 → XP_038538785.1  LOW QUALITY PROTEIN: POU domain, class 5, transcription factor 1

    UniProtKB/TrEMBL
    A0A8I3PB46
    Related
    ENSCAFP00845024367.1, ENSCAFT00845031112.1
    Conserved Domains (2) summary
    smart00352
    Location:138 → 212
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:233 → 287
    Homeobox; Homeobox domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    864674..869639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038492747.1 → XP_038348675.1  LOW QUALITY PROTEIN: POU domain, class 5, transcription factor 1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    932964..937930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038617209.1 → XP_038473137.1  POU domain, class 5, transcription factor 1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    1000755..1005716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038553312.1 → XP_038409240.1  POU domain, class 5, transcription factor 1

    UniProtKB/TrEMBL
    A0A8C0L622, A0A8C0MBD5, A0A8I3PB46, A0A8P0N3Q7

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    998319..1003284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_538830.4 → XP_538830.1  POU domain, class 5, transcription factor 1

    UniProtKB/TrEMBL
    A0A8C0L622, A0A8C0MBD5, A0A8I3PB46, A0A8P0N3Q7
    Conserved Domains (2) summary
    smart00352
    Location:138 → 212
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:233 → 286
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version

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