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SMAD5 SMAD family member 5 [ Canis lupus familiaris (dog) ]

Gene ID: 481520, updated on 5-Mar-2024

Summary

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Official Symbol
SMAD5provided by VGNC
Official Full Name
SMAD family member 5provided by VGNC
Primary source
VGNC:VGNC:46522
See related
Ensembl:ENSCAFG00845014450
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (24843618..24898398)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (22774580..22829238)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (24046574..24101311)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (23530270..23584907)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (23397527..23452566)

Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097931 Neighboring gene uncharacterized LOC119874033 Neighboring gene small integral membrane protein 32 Neighboring gene uncharacterized LOC106559472

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051815.1 Reference ROS_Cfam_1.0

    Range
    24843618..24898398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038681592.1 → XP_038537520.1  mothers against decapentaplegic homolog 5

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Related
    ENSCAFP00845020381.1, ENSCAFT00845025864.1
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  2. XM_038681594.1 → XP_038537522.1  mothers against decapentaplegic homolog 5

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  3. XM_038681593.1 → XP_038537521.1  mothers against decapentaplegic homolog 5

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Related
    ENSCAFP00845020370.1, ENSCAFT00845025852.1
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049271.1 Alternate UMICH_Zoey_3.1

    Range
    23530270..23584907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038490157.1 → XP_038346085.1  mothers against decapentaplegic homolog 5

    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  2. XM_038490159.1 → XP_038346087.1  mothers against decapentaplegic homolog 5

    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  3. XM_038490158.1 → XP_038346086.1  mothers against decapentaplegic homolog 5

    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

    Range
    23397527..23452566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038616104.1 → XP_038472032.1  mothers against decapentaplegic homolog 5

    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  2. XM_038616106.1 → XP_038472034.1  mothers against decapentaplegic homolog 5

    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  3. XM_038616105.1 → XP_038472033.1  mothers against decapentaplegic homolog 5

    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

    Range
    24046574..24101311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038552236.1 → XP_038408164.1  mothers against decapentaplegic homolog 5

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  2. XM_038552238.1 → XP_038408166.1  mothers against decapentaplegic homolog 5

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  3. XM_038552237.1 → XP_038408165.1  mothers against decapentaplegic homolog 5

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    22774580..22829238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_538641.7 → XP_538641.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for XP_538641.1

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  2. XM_005626570.3 → XP_005626627.1  mothers against decapentaplegic homolog 5

    See identical proteins and their annotated locations for XP_005626627.1

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

  3. XM_038657632.1 → XP_038513560.1  mothers against decapentaplegic homolog 5

    UniProtKB/TrEMBL
    A0A8C0MNB8, A0A8I3NW84, A0A8I3P2F5, A0A8P0N4A6
    Conserved Domains (2) summary
    cd10490
    Location:10 → 133
    MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)
    cd10497
    Location:265 → 465
    MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9
Nucleotide Protein
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