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APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 [ Canis lupus familiaris (dog) ]

Gene ID: 481297, updated on 5-Mar-2024

Summary

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Official Symbol
APPL2provided by VGNC
Official Full Name
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2provided by VGNC
Primary source
VGNC:VGNC:38013
See related
Ensembl:ENSCAFG00845005921
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (34033756..34084221)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (33111933..33162406)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (34246325..34297170)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (33769093..33819698)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (34053225..34103854)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene chromosome 10 C12orf75 homolog Neighboring gene 40S ribosomal protein S13-like Neighboring gene WASH complex subunit 4 Neighboring gene aldehyde dehydrogenase 1 family member L2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DCC-interacting protein 13-beta
Names
amyloid beta (A4) precursor-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    34033756..34084221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038680096.1 → XP_038536024.1  DCC-interacting protein 13-beta isoform X4

    Conserved Domains (2) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  2. XM_038680093.1 → XP_038536021.1  DCC-interacting protein 13-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVY4, A0A8I3MVM2
    Related
    ENSCAFP00845008162.1, ENSCAFT00845010496.1
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  3. XM_038680094.1 → XP_038536022.1  DCC-interacting protein 13-beta isoform X2

    UniProtKB/TrEMBL
    A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  4. XM_038680095.1 → XP_038536023.1  DCC-interacting protein 13-beta isoform X3

    UniProtKB/TrEMBL
    A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:417 → 550
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cl17171
    Location:252 → 313
    PH-like; Pleckstrin homology-like domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    33769093..33819698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038488844.1 → XP_038344772.1  DCC-interacting protein 13-beta isoform X4

    Conserved Domains (2) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  2. XM_038488841.1 → XP_038344769.1  DCC-interacting protein 13-beta isoform X1

    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  3. XM_038488842.1 → XP_038344770.1  DCC-interacting protein 13-beta isoform X2

    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  4. XM_038488843.1 → XP_038344771.1  DCC-interacting protein 13-beta isoform X3

    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:417 → 550
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cl17171
    Location:252 → 313
    PH-like; Pleckstrin homology-like domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    34053225..34103854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038614728.1 → XP_038470656.1  DCC-interacting protein 13-beta isoform X4

    Conserved Domains (2) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  2. XM_038614725.1 → XP_038470653.1  DCC-interacting protein 13-beta isoform X1

    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  3. XM_038614726.1 → XP_038470654.1  DCC-interacting protein 13-beta isoform X2

    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  4. XM_038614727.1 → XP_038470655.1  DCC-interacting protein 13-beta isoform X3

    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:417 → 550
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cl17171
    Location:252 → 313
    PH-like; Pleckstrin homology-like domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    34246325..34297170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038550808.1 → XP_038406736.1  DCC-interacting protein 13-beta isoform X4

    Conserved Domains (2) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  2. XM_038550805.1 → XP_038406733.1  DCC-interacting protein 13-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVY4, A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  3. XM_038550806.1 → XP_038406734.1  DCC-interacting protein 13-beta isoform X2

    UniProtKB/TrEMBL
    A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  4. XM_038550807.1 → XP_038406735.1  DCC-interacting protein 13-beta isoform X3

    UniProtKB/TrEMBL
    A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:417 → 550
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cl17171
    Location:252 → 313
    PH-like; Pleckstrin homology-like domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    33111933..33162406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022424523.2 → XP_022280231.1  DCC-interacting protein 13-beta isoform X4

    Conserved Domains (2) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  2. XM_538418.6 → XP_538418.2  DCC-interacting protein 13-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVY4, A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  3. XM_005625955.4 → XP_005626012.1  DCC-interacting protein 13-beta isoform X2

    UniProtKB/TrEMBL
    A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:480 → 613
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:252 → 376
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

  4. XM_022424522.2 → XP_022280230.1  DCC-interacting protein 13-beta isoform X3

    UniProtKB/TrEMBL
    A0A8I3MVM2
    Conserved Domains (3) summary
    cd07632
    Location:20 → 234
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:417 → 550
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cl17171
    Location:252 → 313
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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