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PLA2G6 phospholipase A2 group VI [ Canis lupus familiaris (dog) ]

Gene ID: 481256, updated on 5-Mar-2024

Summary

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Official Symbol
PLA2G6provided by VGNC
Official Full Name
phospholipase A2 group VIprovided by VGNC
Primary source
VGNC:VGNC:44631
See related
Ensembl:ENSCAFG00845024672
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (27290620..27351106)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (26454462..26514846)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (27499582..27559773)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (27011336..27071396)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (27322574..27382942)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 184B Neighboring gene MAF bZIP transcription factor F Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2 Neighboring gene uncharacterized LOC119873632 Neighboring gene solute carrier family 16 member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the PLA2G6 c.1579G>A Missense Mutation in Papillon Dog Neuroaxonal Dystrophy Using Whole Exome Sequencing Analysis. Tsuboi M, et al. PLoS One, 2017. PMID 28107443, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiolipin acyl-chain remodeling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
85/88 kDa calcium-independent phospholipase A2
XP_005625946.1
XP_005625947.1
XP_005625948.1
XP_005625949.1
XP_022280162.1
XP_038344584.1
XP_038344585.1
XP_038344586.1
XP_038344587.1
XP_038344588.1
XP_038344589.1
XP_038406538.1
XP_038406539.1
XP_038406540.1
XP_038406541.1
XP_038406542.1
XP_038406543.1
XP_038470475.1
XP_038470476.1
XP_038470477.1
XP_038470478.1
XP_038470479.1
XP_038470480.1
XP_038535831.1
XP_038535832.1
XP_038535833.1
XP_038535834.1
XP_038535835.1
XP_038535836.1
XP_861095.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    27290620..27351106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038679904.1 → XP_038535832.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0N2Y1
    Conserved Domains (4) summary
    cd07212
    Location:510 → 789
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:298 → 481
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_038679903.1 → XP_038535831.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JQQ7, A0A8C0N2Y1, A0A8I3PWT0
    Related
    ENSCAFP00845034190.1, ENSCAFT00845043642.1
    Conserved Domains (4) summary
    cd07212
    Location:510 → 823
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:298 → 481
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_038679907.1 → XP_038535835.1  85/88 kDa calcium-independent phospholipase A2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0N2Y1
    Conserved Domains (4) summary
    cd07212
    Location:510 → 788
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:298 → 481
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_038679908.1 → XP_038535836.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0JS04, A0A8C0N812, A0A8I3S8X3
    Related
    ENSCAFP00845034320.1, ENSCAFT00845043799.1
    Conserved Domains (3) summary
    cd07212
    Location:456 → 769
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_038679905.1 → XP_038535833.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8I3PP74
    Related
    ENSCAFP00845034452.1, ENSCAFT00845043964.1
    Conserved Domains (4) summary
    cd07212
    Location:480 → 793
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:268 → 451
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:156 → 249
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_038679906.1 → XP_038535834.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8I3PP74
    Conserved Domains (4) summary
    cd07212
    Location:480 → 793
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:268 → 451
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:156 → 249
    Ank_2; Ankyrin repeats (3 copies)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    27011336..27071396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038488657.1 → XP_038344585.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

  2. XM_038488656.1 → XP_038344584.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

  3. XM_038488660.1 → XP_038344588.1  85/88 kDa calcium-independent phospholipase A2 isoform X4

  4. XM_038488661.1 → XP_038344589.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

  5. XM_038488658.1 → XP_038344586.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

  6. XM_038488659.1 → XP_038344587.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    27322574..27382942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038614548.1 → XP_038470476.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

    Conserved Domains (4) summary
    cd07212
    Location:510 → 789
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:298 → 481
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_038614547.1 → XP_038470475.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

    Conserved Domains (4) summary
    cd07212
    Location:510 → 823
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:298 → 481
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_038614551.1 → XP_038470479.1  85/88 kDa calcium-independent phospholipase A2 isoform X4

    Conserved Domains (4) summary
    cd07212
    Location:510 → 788
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:298 → 481
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_038614552.1 → XP_038470480.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

    Conserved Domains (3) summary
    cd07212
    Location:456 → 769
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:186 → 279
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_038614549.1 → XP_038470477.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    Conserved Domains (4) summary
    cd07212
    Location:480 → 793
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:268 → 451
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:156 → 249
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_038614550.1 → XP_038470478.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    Conserved Domains (4) summary
    cd07212
    Location:480 → 793
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    PHA02876
    Location:268 → 451
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:156 → 249
    Ank_2; Ankyrin repeats (3 copies)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    27499582..27559773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038550611.1 → XP_038406539.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0N2Y1

  2. XM_038550610.1 → XP_038406538.1  85/88 kDa calcium-independent phospholipase A2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8P0N4K1

  3. XM_038550614.1 → XP_038406542.1  85/88 kDa calcium-independent phospholipase A2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0N2Y1

  4. XM_038550615.1 → XP_038406543.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0N812, A0A8P0T9D1

  5. XM_038550612.1 → XP_038406540.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8P0S7C5

  6. XM_038550613.1 → XP_038406541.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8P0S7C5

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26454462..26514846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005625889.4 → XP_005625946.1  85/88 kDa calcium-independent phospholipase A2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0N2Y1
    Conserved Domains (4) summary
    cd07212
    Location:510 → 789
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:315 → 433
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:321 → 410
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]

  2. XM_856002.6 → XP_861095.2  85/88 kDa calcium-independent phospholipase A2 isoform X1

    See identical proteins and their annotated locations for XP_861095.2

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8P0N4K1
    Conserved Domains (4) summary
    cd07212
    Location:510 → 823
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:315 → 433
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:321 → 410
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]

  3. XM_005625891.4 → XP_005625948.1  85/88 kDa calcium-independent phospholipase A2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0N2Y1
    Conserved Domains (4) summary
    cd07212
    Location:510 → 788
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:315 → 433
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:321 → 410
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]

  4. XM_005625892.4 → XP_005625949.1  85/88 kDa calcium-independent phospholipase A2 isoform X5

    See identical proteins and their annotated locations for XP_005625949.1

    UniProtKB/TrEMBL
    A0A8C0N812, A0A8P0T9D1
    Conserved Domains (4) summary
    cd07212
    Location:456 → 769
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:244 → 400
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:321 → 410
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:316 → 344
    ANK; ANK repeat [structural motif]

  5. XM_005625890.4 → XP_005625947.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    See identical proteins and their annotated locations for XP_005625947.1

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8P0S7C5
    Conserved Domains (4) summary
    cd07212
    Location:480 → 793
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:285 → 403
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:103 → 183
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_022424454.2 → XP_022280162.1  85/88 kDa calcium-independent phospholipase A2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0N2Y1, A0A8P0S7C5
    Conserved Domains (4) summary
    cd07212
    Location:480 → 793
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:285 → 403
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:286 → 314
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:103 → 183
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
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