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EFCAB6 EF-hand calcium binding domain 6 [ Canis lupus familiaris (dog) ]

Gene ID: 481218, updated on 5-Mar-2024

Summary

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Official Symbol
EFCAB6provided by VGNC
Official Full Name
EF-hand calcium binding domain 6provided by VGNC
Primary source
VGNC:VGNC:40217
See related
Ensembl:ENSCAFG00845013088
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
33
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (22578629..22812813)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (21770460..22004508)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (22792207..23026524)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (22297954..22531928)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (22618101..22851011)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119873616 Neighboring gene uncharacterized LOC111097629 Neighboring gene sulfotransferase family 4A member 1 Neighboring gene uncharacterized LOC119873617 Neighboring gene uncharacterized LOC111097630 Neighboring gene uncharacterized LOC119873618 Neighboring gene metallophosphoesterase domain containing 1 Neighboring gene uncharacterized LOC111097631 Neighboring gene signal peptide, CUB domain and EGF like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    22578629..22812813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038679598.1 → XP_038535526.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SE44, A0A8I3NR57
    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1337 → 1501
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1440 → 1500
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_038679600.1 → XP_038535528.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SD26
    Conserved Domains (6) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:882 → 1034
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    cl08302
    Location:1334 → 1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_038679601.1 → XP_038535529.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    A0A8C0YWX8, A0A8I3NFX8
    Related
    ENSCAFP00845018751.1, ENSCAFT00845023875.1
    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1260 → 1424
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1217
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1363 → 1423
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_038679597.1 → XP_038535525.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SE44, A0A8I3NR57
    Related
    ENSCAFP00845018431.1, ENSCAFT00845023482.1
    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1337 → 1501
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1440 → 1500
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_038679599.1 → XP_038535527.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SFQ4, A0A8I3NLH5
    Related
    ENSCAFP00845018566.1, ENSCAFT00845023651.1
    Conserved Domains (6) summary
    COG5126
    Location:1285 → 1449
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:800 → 828
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:800 → 856
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1109 → 1209
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1388 → 1448
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:368 → 416
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_038679602.1 → XP_038535530.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I3NRF6, A0A8P0TMD9
    Related
    ENSCAFP00845019042.1, ENSCAFT00845024237.1
    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_038679603.1 → XP_038535531.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I3NRF6, A0A8P0TMD9
    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    22297954..22531928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038488369.1 → XP_038344297.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1337 → 1501
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1440 → 1500
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_038488371.1 → XP_038344299.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

    Conserved Domains (6) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:882 → 1034
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    cl08302
    Location:1334 → 1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_038488372.1 → XP_038344300.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1260 → 1424
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1217
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1363 → 1423
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_038488368.1 → XP_038344296.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1337 → 1501
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1440 → 1500
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_038488370.1 → XP_038344298.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

    Conserved Domains (6) summary
    COG5126
    Location:1285 → 1449
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:800 → 828
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:800 → 856
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1109 → 1209
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1388 → 1448
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:368 → 416
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_038488373.1 → XP_038344301.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_038488374.1 → XP_038344302.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    22618101..22851011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038614259.1 → XP_038470187.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

  2. XM_038614261.1 → XP_038470189.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

  3. XM_038614262.1 → XP_038470190.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

  4. XM_038614258.1 → XP_038470186.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

  5. XM_038614260.1 → XP_038470188.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

  6. XM_038614263.1 → XP_038470191.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

  7. XM_038614264.1 → XP_038470192.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    22792207..23026524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038550277.1 → XP_038406205.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SE44, A0A8I3NR57

  2. XM_038550279.1 → XP_038406207.1  EF-hand calcium-binding domain-containing protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A8C0M862
    Conserved Domains (6) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:882 → 1034
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    cl08302
    Location:1334 → 1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_038550280.1 → XP_038406208.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    A0A8C0MF75, A0A8C0YWX8, A0A8I3NFX8
    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1260 → 1424
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1217
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1363 → 1423
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_038550276.1 → XP_038406204.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SE44, A0A8I3NR57

  5. XM_038550278.1 → XP_038406206.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SFQ4

  6. XM_038550281.1 → XP_038406209.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I3NRF6, A0A8P0TMD9
    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_038550282.1 → XP_038406210.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I3NRF6, A0A8P0TMD9
    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21770460..22004508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_538339.7 → XP_538339.3  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SE44, A0A8I3NR57
    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1337 → 1501
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1440 → 1500
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_014117294.3 → XP_013972769.2  EF-hand calcium-binding domain-containing protein 6 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SD26
    Conserved Domains (6) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:882 → 1034
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    cl08302
    Location:1334 → 1379
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_038637259.1 → XP_038493187.1  EF-hand calcium-binding domain-containing protein 6 isoform X4

    UniProtKB/TrEMBL
    A0A8C0YWX8, A0A8I3NFX8
    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1260 → 1424
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1217
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1363 → 1423
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_022424329.2 → XP_022280037.1  EF-hand calcium-binding domain-containing protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SE44, A0A8I3NR57
    Conserved Domains (7) summary
    PTZ00184
    Location:77 → 241
    PTZ00184; calmodulin; Provisional
    COG5126
    Location:1337 → 1501
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:852 → 880
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:852 → 908
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1161 → 1261
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1440 → 1500
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:420 → 468
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_022424331.2 → XP_022280039.1  EF-hand calcium-binding domain-containing protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SFQ4, A0A8I3NLH5
    Conserved Domains (6) summary
    COG5126
    Location:1285 → 1449
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:800 → 828
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:800 → 856
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1109 → 1209
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1388 → 1448
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:368 → 416
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_014117295.3 → XP_013972770.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I3NRF6, A0A8P0TMD9
    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_038637270.1 → XP_038493198.1  EF-hand calcium-binding domain-containing protein 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I3NRF6, A0A8P0TMD9
    Conserved Domains (6) summary
    COG5126
    Location:1199 → 1363
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd15898
    Location:714 → 742
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:714 → 770
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam08976
    Location:1023 → 1123
    EF-hand_11; EF-hand domain
    pfam13499
    Location:1302 → 1362
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:40 → 98
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
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