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STAT2 signal transducer and activator of transcription 2 [ Canis lupus familiaris (dog) ]

Gene ID: 481111, updated on 11-Apr-2024

Summary

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Official Symbol
STAT2provided by VGNC
Official Full Name
signal transducer and activator of transcription 2provided by VGNC
Primary source
VGNC:VGNC:108218
See related
Ensembl:ENSCAFG00845008098
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (650365..669707, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (704962..724101, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (994493..1013823, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (627617..646943, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (870771..890099, complement)

Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111089980 Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene interleukin 23 subunit alpha Neighboring gene 60S ribosomal protein L6-like Neighboring gene apolipoprotein F Neighboring gene timeless circadian regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051814.1 Reference ROS_Cfam_1.0

    Range
    650365..669707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038679015.1 → XP_038534943.1  signal transducer and activator of transcription 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LLW2, A0A8I3N7X7
    Conserved Domains (5) summary
    cd10373
    Location:549 → 699
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:310 → 468
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 306
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:783 → 835
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  2. XM_038679013.1 → XP_038534941.1  signal transducer and activator of transcription 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
    Related
    ENSCAFP00845011091.1, ENSCAFT00845014314.1
    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  3. XM_038679014.1 → XP_038534942.1  signal transducer and activator of transcription 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  4. XM_038679016.1 → XP_038534944.1  signal transducer and activator of transcription 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QAL2
    Conserved Domains (4) summary
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    cl15255
    Location:555 → 680
    SH2; Src homology 2 (SH2) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049270.1 Alternate UMICH_Zoey_3.1

    Range
    627617..646943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487796.1 → XP_038343724.1  signal transducer and activator of transcription 2 isoform X2

    Conserved Domains (5) summary
    cd10373
    Location:549 → 699
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:310 → 468
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 306
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:783 → 835
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  2. XM_038487794.1 → XP_038343722.1  signal transducer and activator of transcription 2 isoform X1

    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  3. XM_038487795.1 → XP_038343723.1  signal transducer and activator of transcription 2 isoform X1

    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  4. XM_038487797.1 → XP_038343725.1  signal transducer and activator of transcription 2 isoform X3

    Conserved Domains (4) summary
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    cl15255
    Location:555 → 680
    SH2; Src homology 2 (SH2) domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

    Range
    870771..890099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613650.1 → XP_038469578.1  signal transducer and activator of transcription 2 isoform X2

    Conserved Domains (5) summary
    cd10373
    Location:549 → 699
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:310 → 468
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 306
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:783 → 835
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  2. XM_038613648.1 → XP_038469576.1  signal transducer and activator of transcription 2 isoform X1

    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  3. XM_038613649.1 → XP_038469577.1  signal transducer and activator of transcription 2 isoform X1

    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  4. XM_038613651.1 → XP_038469579.1  signal transducer and activator of transcription 2 isoform X3

    Conserved Domains (4) summary
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    cl15255
    Location:555 → 680
    SH2; Src homology 2 (SH2) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

    Range
    994493..1013823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549685.1 → XP_038405613.1  signal transducer and activator of transcription 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0LLW2, A0A8I3N7X7
    Conserved Domains (5) summary
    cd10373
    Location:549 → 699
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:310 → 468
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 306
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:783 → 835
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  2. XM_038549683.1 → XP_038405611.1  signal transducer and activator of transcription 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  3. XM_038549684.1 → XP_038405612.1  signal transducer and activator of transcription 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LLW2, A0A8I3N2N6, A0A8I3N7X7
    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  4. XM_038549686.1 → XP_038405614.1  signal transducer and activator of transcription 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QAL2
    Conserved Domains (4) summary
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    cl15255
    Location:555 → 680
    SH2; Src homology 2 (SH2) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    704962..724101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014117155.3 → XP_013972630.2  signal transducer and activator of transcription 2 isoform X2

    UniProtKB/TrEMBL
    A0A8P0TDJ5
    Conserved Domains (5) summary
    cd10373
    Location:549 → 699
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:310 → 468
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 306
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:783 → 835
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  2. XM_538232.6 → XP_538232.3  signal transducer and activator of transcription 2 isoform X1

    UniProtKB/TrEMBL
    A0A8P0N3D7, A0A8P0TDJ5
    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  3. XM_038632890.1 → XP_038488818.1  signal transducer and activator of transcription 2 isoform X1

    UniProtKB/TrEMBL
    A0A8P0N3D7, A0A8P0TDJ5
    Conserved Domains (5) summary
    cd10373
    Location:555 → 705
    SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    cd16846
    Location:316 → 474
    STAT2_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 2 (STAT2)
    cl28921
    Location:141 → 312
    STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    pfam12188
    Location:789 → 841
    STAT2_C; Signal transducer and activator of transcription 2 C terminal

  4. XM_014117156.3 → XP_013972631.1  signal transducer and activator of transcription 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QAL2
    Conserved Domains (4) summary
    smart00964
    Location:2 → 124
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:142 → 314
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:316 → 564
    STAT_bind; STAT protein, DNA binding domain
    cl15255
    Location:555 → 680
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
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