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FLNA filamin A [ Canis lupus familiaris (dog) ]

Gene ID: 481084, updated on 5-Mar-2024

Summary

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Official Symbol
FLNAprovided by VGNC
Official Full Name
filamin Aprovided by VGNC
Primary source
VGNC:VGNC:40900
See related
Ensembl:ENSCAFG00845027901
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
48
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (125200002..125225183)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (107387038..107412214)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (123246013..123271198)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (120969062..120994237)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (123484172..123509345)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119868253 Neighboring gene emerin Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ribosomal protein L10 Neighboring gene deoxyribonuclease 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Filamin interacts with epithelial sodium channel and inhibits its channel function. Wang Q, et al. J Biol Chem, 2013 Jan 4. PMID 23161538, Free PMC Article
  2. Filamin acts as a key regulator in epithelial defence against transformed cells. Kajita M, et al. Nat Commun, 2014 Jul 31. PMID 25079702

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of filamin A or vimentin in normal cells profoundly suppresses apical extrusion of the neighbouring transformed cells.
    Title: Filamin acts as a key regulator in epithelial defence against transformed cells.
  2. filamin reduces ENaC channel function through direct interaction on the cell surface
    Title: Filamin interacts with epithelial sodium channel and inhibits its channel function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
filamin-A
Names
filamin A, alpha (actin binding protein 280)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    125200002..125225183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038451275.1 → XP_038307203.1  filamin-A isoform X1

    UniProtKB/TrEMBL
    A0A8C0TBZ3, A0A8C0TD88, A0A8I3Q4P5, A0A8I3Q522
    Related
    ENSCAFP00845039096.1, ENSCAFT00845049849.1
    Conserved Domains (3) summary
    smart00557
    Location:1067 → 1156
    IG_FLMN; Filamin-type immunoglobulin domains
    cd21308
    Location:25 → 153
    CH_FLNA_rpt1; first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
    cd21312
    Location:156 → 269
    CH_FLNA_rpt2; second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins

  2. XM_038451276.1 → XP_038307204.1  filamin-A isoform X2

    UniProtKB/TrEMBL
    A0A8C0TD88, A0A8I3Q522, A0A8I3S6R3, A0A8P0T542
    Related
    ENSCAFP00845039457.1, ENSCAFT00845050329.1
    Conserved Domains (3) summary
    smart00557
    Location:1067 → 1156
    IG_FLMN; Filamin-type immunoglobulin domains
    cd21308
    Location:25 → 153
    CH_FLNA_rpt1; first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
    cd21312
    Location:156 → 269
    CH_FLNA_rpt2; second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    120969062..120994237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038524744.1 → XP_038380672.1  filamin-A isoform X1

    Conserved Domains (3) summary
    smart00557
    Location:1067 → 1156
    IG_FLMN; Filamin-type immunoglobulin domains
    cd21308
    Location:25 → 153
    CH_FLNA_rpt1; first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
    cd21312
    Location:156 → 269
    CH_FLNA_rpt2; second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins

  2. XM_038524745.1 → XP_038380673.1  filamin-A isoform X2

    Conserved Domains (3) summary
    smart00557
    Location:1067 → 1156
    IG_FLMN; Filamin-type immunoglobulin domains
    cd21308
    Location:25 → 153
    CH_FLNA_rpt1; first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
    cd21312
    Location:156 → 269
    CH_FLNA_rpt2; second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    123484172..123509345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653226.1 → XP_038509154.1  filamin-A isoform X1

  2. XM_038653227.1 → XP_038509155.1  filamin-A isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    123246013..123271198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038588707.1 → XP_038444635.1  filamin-A isoform X1

    UniProtKB/TrEMBL
    A0A8C0TD88, A0A8I3Q522

  2. XM_038588708.1 → XP_038444636.1  filamin-A isoform X2

    UniProtKB/TrEMBL
    A0A8C0TD88, A0A8I3Q522

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    107387038..107412214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464354.1 → XP_038320282.1  filamin-A isoform X1

    UniProtKB/TrEMBL
    A0A8C0TBZ3, A0A8C0TD88, A0A8I3Q4P5, A0A8I3Q522
    Conserved Domains (3) summary
    smart00557
    Location:1067 → 1156
    IG_FLMN; Filamin-type immunoglobulin domains
    cd21308
    Location:25 → 153
    CH_FLNA_rpt1; first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
    cd21312
    Location:156 → 269
    CH_FLNA_rpt2; second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins

  2. XM_038464355.1 → XP_038320283.1  filamin-A isoform X2

    UniProtKB/TrEMBL
    A0A8C0TD88, A0A8I3Q522, A0A8I3S6R3, A0A8P0T542
    Conserved Domains (3) summary
    smart00557
    Location:1067 → 1156
    IG_FLMN; Filamin-type immunoglobulin domains
    cd21308
    Location:25 → 153
    CH_FLNA_rpt1; first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
    cd21312
    Location:156 → 269
    CH_FLNA_rpt2; second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins
Nucleotide Protein
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