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HDAC6 histone deacetylase 6 [ Canis lupus familiaris (dog) ]

Gene ID: 480907, updated on 5-Mar-2024

Summary

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Official Symbol
HDAC6provided by VGNC
Official Full Name
histone deacetylase 6provided by VGNC
Primary source
VGNC:VGNC:50630
See related
Ensembl:ENSCAFG00845030925
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
32
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (42140437..42160915)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (16379688..16400160)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (42209124..42229594)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (42126695..42147162)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (42114965..42135438)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene mammalian ependymin-related protein 1-like Neighboring gene GATA binding protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene ES cell expressed Ras Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules. Husain M, et al. J Virol, 2014 Oct. PMID 25031336, Free PMC Article
  2. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Zhang D, et al. Circulation, 2014 Jan 21. PMID 24146251

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HDAC6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules.
    Title: Histone deacetylase 6 inhibits influenza A virus release by downregulating the trafficking of viral components to the plasma membrane via its substrate, acetylated microtubules.
  2. Atrial fibrillation induces remodeling and loss of contractile function, at least in part through HDAC6 activation and subsequent derailment of alpha-tubulin proteostasis and disruption of the cardiomyocyte microtubule structure.
    Title: Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 6
XP_005641382.2
XP_005641383.2
XP_005641384.2
XP_005641385.2
XP_013967131.2
XP_022271428.2
XP_038305878.1
XP_038305879.1
XP_038305880.1
XP_038305881.1
XP_038305883.1
XP_038305884.1
XP_038379327.1
XP_038379328.1
XP_038379330.1
XP_038379331.1
XP_038379332.1
XP_038379333.1
XP_038443297.1
XP_038443298.1
XP_038443299.1
XP_038443300.1
XP_038443301.1
XP_038443302.1
XP_038507810.1
XP_038507811.1
XP_038507812.1
XP_038507813.1
XP_038507814.1
XP_038507815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    42140437..42160915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038449955.1 → XP_038305883.1  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Related
    ENSCAFP00845043222.1, ENSCAFT00845054969.1
    Conserved Domains (3) summary
    cd10003
    Location:489 → 839
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1066 → 1128
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:99 → 440
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. XM_038449951.1 → XP_038305879.1  histone deacetylase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:557 → 907
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1134 → 1196
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:167 → 508
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  3. XM_038449950.1 → XP_038305878.1  histone deacetylase 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:558 → 908
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1135 → 1197
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:168 → 509
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  4. XM_038449952.1 → XP_038305880.1  histone deacetylase 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q5U6, A0A8I3QQ94, A0A8P0NH53, A0A8P0P368
    Related
    ENSCAFP00845043227.1, ENSCAFT00845054976.1
    Conserved Domains (3) summary
    cd10003
    Location:553 → 903
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1130 → 1192
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:168 → 504
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  5. XM_038449956.1 → XP_038305884.1  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:489 → 839
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1066 → 1128
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:99 → 440
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  6. XM_038449953.1 → XP_038305881.1  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:489 → 839
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1066 → 1128
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:99 → 440
    Arginase_HDAC; Arginase-like and histone-like hydrolases

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    42126695..42147162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038523404.1 → XP_038379332.1  histone deacetylase 6 isoform X4

  2. XM_038523400.1 → XP_038379328.1  histone deacetylase 6 isoform X2

  3. XM_038523399.1 → XP_038379327.1  histone deacetylase 6 isoform X1

  4. XM_038523402.1 → XP_038379330.1  histone deacetylase 6 isoform X3

  5. XM_038523405.1 → XP_038379333.1  histone deacetylase 6 isoform X4

  6. XM_038523403.1 → XP_038379331.1  histone deacetylase 6 isoform X4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    42114965..42135438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038651886.1 → XP_038507814.1  histone deacetylase 6 isoform X4

  2. XM_038651883.1 → XP_038507811.1  histone deacetylase 6 isoform X2

  3. XM_038651882.1 → XP_038507810.1  histone deacetylase 6 isoform X1

  4. XM_038651884.1 → XP_038507812.1  histone deacetylase 6 isoform X3

  5. XM_038651887.1 → XP_038507815.1  histone deacetylase 6 isoform X4

  6. XM_038651885.1 → XP_038507813.1  histone deacetylase 6 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    42209124..42229594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038587373.1 → XP_038443301.1  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8C0S234

  2. XM_038587370.1 → XP_038443298.1  histone deacetylase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8C0S234

  3. XM_038587369.1 → XP_038443297.1  histone deacetylase 6 isoform X1

    UniProtKB/TrEMBL
    A0A8C0S234

  4. XM_038587371.1 → XP_038443299.1  histone deacetylase 6 isoform X3

    UniProtKB/TrEMBL
    A0A8C0ML56, A0A8C0S234

  5. XM_038587374.1 → XP_038443302.1  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8C0S234

  6. XM_038587372.1 → XP_038443300.1  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8C0S234

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    16379688..16400160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005641326.4 → XP_005641383.2  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:489 → 839
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1066 → 1128
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:99 → 440
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  2. XM_022415720.2 → XP_022271428.2  histone deacetylase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:557 → 907
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1134 → 1196
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:167 → 508
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  3. XM_005641328.4 → XP_005641385.2  histone deacetylase 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:558 → 908
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1135 → 1197
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:168 → 509
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  4. XM_014111656.3 → XP_013967131.2  histone deacetylase 6 isoform X3

    UniProtKB/TrEMBL
    A0A8I3Q5U6, A0A8I3QQ94, A0A8P0NH53, A0A8P0P368
    Conserved Domains (3) summary
    cd10003
    Location:553 → 903
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1130 → 1192
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:168 → 504
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  5. XM_005641327.4 → XP_005641384.2  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:489 → 839
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1066 → 1128
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:99 → 440
    Arginase_HDAC; Arginase-like and histone-like hydrolases

  6. XM_005641325.4 → XP_005641382.2  histone deacetylase 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I3QQ94, A0A8P0NH53
    Conserved Domains (3) summary
    cd10003
    Location:489 → 839
    HDAC6-dom2; Histone deacetylase 6, domain 2
    pfam02148
    Location:1066 → 1128
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl17011
    Location:99 → 440
    Arginase_HDAC; Arginase-like and histone-like hydrolases
Nucleotide Protein
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