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NOTCH1 notch receptor 1 [ Canis lupus familiaris (dog) ]

Gene ID: 480676, updated on 5-Mar-2024

Summary

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Official Symbol
NOTCH1provided by VGNC
Official Full Name
notch receptor 1provided by VGNC
Primary source
VGNC:VGNC:43898
See related
Ensembl:ENSCAFG00845005453
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
N1ICD
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
34
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (49852205..49895734)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (48226361..48269900)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (48974423..49017941)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (48633237..48676758)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (48926759..48970231)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene microRNA mir-126 Neighboring gene EGF like domain multiple 7 Neighboring gene formin-like protein 7 Neighboring gene SEC16 homolog A, endoplasmic reticulum export factor Neighboring gene inositol polyphosphate-5-phosphatase E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurogenic locus notch homolog protein 1
Names
Notch homolog 1, translocation-associated
notch 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    49852205..49895734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038677974.1 → XP_038533902.1  neurogenic locus notch homolog protein 1

    UniProtKB/TrEMBL
    A0A8C0RBT3, A0A8I3MTK6, A0A8P0TTH3
    Related
    ENSCAFP00845007633.1, ENSCAFT00845009762.1
    Conserved Domains (10) summary
    smart00004
    Location:1443 → 1480
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1930 → 2120
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:870 → 906
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1879 → 1924
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1533 → 1562
    Notch; LNR domain
    pfam06816
    Location:1568 → 1622
    NOD; NOTCH protein
    pfam07684
    Location:1672 → 1731
    NODP; NOTCH protein
    pfam11936
    Location:2497 → 2559
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1931 → 2024
    Ank_2; Ankyrin repeats (3 copies)
    cd21702
    Location:1719 → 1798
    JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    48633237..48676758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486885.1 → XP_038342813.1  neurogenic locus notch homolog protein 1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    48926759..48970231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038612681.1 → XP_038468609.1  neurogenic locus notch homolog protein 1

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    48974423..49017941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038548751.1 → XP_038404679.1  neurogenic locus notch homolog protein 1

    UniProtKB/TrEMBL
    A0A8C0RBT3, A0A8I3MTK6, A0A8P0TTH3
    Conserved Domains (10) summary
    smart00004
    Location:1443 → 1480
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1930 → 2120
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:870 → 906
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1879 → 1924
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1533 → 1562
    Notch; LNR domain
    pfam06816
    Location:1568 → 1622
    NOD; NOTCH protein
    pfam07684
    Location:1672 → 1731
    NODP; NOTCH protein
    pfam11936
    Location:2497 → 2559
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1931 → 2024
    Ank_2; Ankyrin repeats (3 copies)
    cd21702
    Location:1719 → 1798
    JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    48226361..48269900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038614892.1 → XP_038470820.1  neurogenic locus notch homolog protein 1

    UniProtKB/TrEMBL
    A0A8C0RBT3, A0A8I3MTK6, A0A8P0TTH3
    Conserved Domains (10) summary
    smart00004
    Location:1443 → 1480
    NL; Domain found in Notch and Lin-12
    COG0666
    Location:1930 → 2120
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:870 → 906
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1879 → 1924
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1533 → 1562
    Notch; LNR domain
    pfam06816
    Location:1568 → 1622
    NOD; NOTCH protein
    pfam07684
    Location:1672 → 1731
    NODP; NOTCH protein
    pfam11936
    Location:2497 → 2559
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1931 → 2024
    Ank_2; Ankyrin repeats (3 copies)
    cd21702
    Location:1719 → 1798
    JMTM_Notch1; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins
Nucleotide Protein
Heading Accession and Version

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