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CLTC clathrin heavy chain [ Canis lupus familiaris (dog) ]

Gene ID: 480578, updated on 5-Mar-2024

Summary

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Official Symbol
CLTCprovided by VGNC
Official Full Name
clathrin heavy chainprovided by VGNC
Primary source
VGNC:VGNC:39367
See related
Ensembl:ENSCAFG00845025273
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
33
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (34925162..34993363)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (33348834..33415377)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (34082574..34149196)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (33708907..33777008)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (33995028..34063165)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097411 Neighboring gene uncharacterized LOC111097412 Neighboring gene DEAH-box helicase 40 Neighboring gene peptidyl-tRNA hydrolase 2 Neighboring gene vacuole membrane protein 1 Neighboring gene microRNA mir-21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clathrin is a key regulator of basolateral polarity. Deborde S, et al. Nature, 2008 Apr 10. PMID 18401403, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables clathrin light chain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of clathrin coat of coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of clathrin coat of trans-Golgi network vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of clathrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in clathrin-coated endocytic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
clathrin heavy chain 1; LOW QUALITY PROTEIN: clathrin heavy chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    34925162..34993363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038677160.1 → XP_038533088.1  clathrin heavy chain 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LRS6, A0A8C0MFZ6, A0A8I3PQE6
    Related
    ENSCAFP00845035373.1, ENSCAFT00845045118.1
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

  2. XM_038677161.1 → XP_038533089.1  clathrin heavy chain 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0ME72
    Related
    ENSCAFP00845035009.1, ENSCAFT00845044680.1
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    33708907..33777008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038486135.1 → XP_038342063.1  clathrin heavy chain 1 isoform X1

    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

  2. XM_038486136.1 → XP_038342064.1  clathrin heavy chain 1 isoform X2

    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    33995028..34063165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611920.1 → XP_038467848.1  clathrin heavy chain 1 isoform X1

    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

  2. XM_038611921.1 → XP_038467849.1  clathrin heavy chain 1 isoform X2

    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    34082574..34149196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547956.1 → XP_038403884.1  LOW QUALITY PROTEIN: clathrin heavy chain 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0ME72
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    33348834..33415377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005624748.4 → XP_005624805.1  clathrin heavy chain 1 isoform X1

    See identical proteins and their annotated locations for XP_005624805.1

    UniProtKB/TrEMBL
    A0A8C0LRS6, A0A8C0MFZ6, A0A8I3PQE6
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link

  2. XM_537700.7 → XP_537700.2  clathrin heavy chain 1 isoform X2

    See identical proteins and their annotated locations for XP_537700.2

    UniProtKB/TrEMBL
    A0A8C0ME72
    Conserved Domains (6) summary
    smart00299
    Location:1274 → 1416
    CLH; Clathrin heavy chain repeat homology
    sd00006
    Location:1105 → 1131
    TPR; TPR repeat [structural motif]
    pfam00637
    Location:979 → 1119
    Clathrin; Region in Clathrin and VPS
    pfam01394
    Location:198 → 234
    Clathrin_propel; Clathrin propeller repeat
    pfam09268
    Location:331 → 354
    Clathrin-link; Clathrin, heavy-chain linker
    pfam13838
    Location:356 → 421
    Clathrin_H_link; Clathrin-H-link
Nucleotide Protein
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