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MAP3K3 mitogen-activated protein kinase kinase kinase 3 [ Canis lupus familiaris (dog) ]

Gene ID: 480481, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K3provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 3provided by VGNC
Primary source
VGNC:VGNC:42973
See related
Ensembl:ENSCAFG00845019265
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (13276493..13339186)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (12572499..12638395)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (15248794..15314683, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (12220815..12286279)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (15245905..15311520, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of cytochrome c oxidase I Neighboring gene uncharacterized LOC119873249 Neighboring gene LIM domain containing 2 Neighboring gene STE20 related adaptor alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 3
XP_022278530.1
XP_038341066.1
XP_038402834.1
XP_038402835.1
XP_038466805.1
XP_038466807.1
XP_038531218.1
XP_537600.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    13276493..13339186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038675290.1 → XP_038531218.1  mitogen-activated protein kinase kinase kinase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0SSR2
    Related
    ENSCAFP00845026610.1, ENSCAFT00845034003.1
    Conserved Domains (2) summary
    cd06625
    Location:375 → 635
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases
    cl02720
    Location:70 → 137
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    12220815..12286279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485138.1 → XP_038341066.1  mitogen-activated protein kinase kinase kinase 3 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    15245905..15311520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038610879.1 → XP_038466807.1  mitogen-activated protein kinase kinase kinase 3 isoform X4

  2. XM_038610877.1 → XP_038466805.1  mitogen-activated protein kinase kinase kinase 3 isoform X3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    15248794..15314683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038546907.1 → XP_038402835.1  mitogen-activated protein kinase kinase kinase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8C0SSR2

  2. XM_038546906.1 → XP_038402834.1  mitogen-activated protein kinase kinase kinase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8C0LQY8, A0A8C0N5V6, A0A8C0SSR2, A0A8P0NN13

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    12572499..12638395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022422822.2 → XP_022278530.1  mitogen-activated protein kinase kinase kinase 3 isoform X8

    UniProtKB/TrEMBL
    A0A8C0SSR2
    Conserved Domains (2) summary
    cd06405
    Location:35 → 113
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06625
    Location:351 → 611
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

  2. XM_537600.6 → XP_537600.2  mitogen-activated protein kinase kinase kinase 3 isoform X7

    UniProtKB/TrEMBL
    A0A8C0LQY8, A0A8C0N5V6, A0A8C0SSR2, A0A8P0NN13
    Conserved Domains (2) summary
    cd06405
    Location:45 → 123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06625
    Location:361 → 621
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases
Nucleotide Protein
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