HIF1A hypoxia inducible factor 1 subunit alpha [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: HIF1Aprovided by VGNC
Official Full Name: hypoxia inducible factor 1 subunit alphaprovided by VGNC
Primary source: VGNC:VGNC:41686
See related: Ensembl:ENSCAFG00845023223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	8	NC_051812.1 (36847226..36889848)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	8	NC_006590.4 (36366891..36409562)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	8	NC_049229.1 (36896640..36939279)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	8	NC_049268.1 (36456745..36499380)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	8	NC_049749.1 (36534215..36576862)

Chromosome 8 - NC_051812.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase.
Title: Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase.
HIF-1alpha is a reliable negative prognostic marker in canine appendicular osteosarcoma.
Title: Clinical significance and in vitro cellular regulation of hypoxia mimicry on HIF-1α and downstream genes in canine appendicular osteosarcoma.
Oxidative Stress in Canine Histiocytic Sarcoma Cells Induced by an Infection with Canine Distemper Virus Led to a Dysregulation of HIF-1alpha Downstream Pathway Resulting in a Reduced Expression of VEGF-B in vitro.
Title: Oxidative Stress in Canine Histiocytic Sarcoma Cells Induced by an Infection with Canine Distemper Virus Led to a Dysregulation of HIF-1α Downstream Pathway Resulting in a Reduced Expression of VEGF-B in vitro.
BAMBI is identified in this pathway as a novel HIF1A-regulated gene that contributes to hypoxia-induced loss of epithelial polarity.
Title: BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
demonstrate for the first time that PPS is a novel inhibitor of IL-1beta-induced iNOS, c-Jun, and HIF-1alpha mRNA upregulation and iNOS protein induction which may be beneficial for prevention and treatment OA
Title: Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes.
The results of this study imply that HIF-1alpha may potentially play a role in increased malignancy of canine mammary tumours
Title: Analysis of Hypoxia-Inducible Factor-1α Expression Relative to Other Key Factors in Malignant Canine Mammary Tumours.
Results of this study indicate a similar biological role of HIF-1alpha in dogs and in humans, which may confirm suitability of the animal model in investigations on progression of tumours in humans.
Title: Expression of hypoxia-inducible factor-1α and vascular density in mammary adenomas and adenocarcinomas in bitches.
Regional hypoxia in renal cysts contributes to cyst growth, primarily due to HIF-1alpha-dependent calcium-activated chloride secretion
Title: Hypoxia-inducible factor-1α causes renal cyst expansion through calcium-activated chloride secretion.
The effect of acute and chronic goniodysgenesis-related glaucoma on teh expression of various stress-inducible proteins in canine retinas is reported.
Title: Comparison of the distribution of glial fibrillary acidic protein, heat shock protein 60, and hypoxia-inducible factor-1alpha in retinas from glaucomatous and normal canine eyes.
in vivo lung expansion by post-pneumonectomy deflation of space-occupying prosthesis elicits coordinated activation of HIF-1alpha signaling in adult lungs
Title: Postpneumonectomy lung expansion elicits hypoxia-inducible factor-1alpha signaling.

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General gene information

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Markers

HIF1A (e-PCR)
- UniSTS:511803

D14S87E (e-PCR)
- UniSTS:147519

MARC_6691-6694:992007331:1 (e-PCR)
- UniSTS:231249

MARC_6693-6692:992007336:1 (e-PCR)
- UniSTS:231250

PMC212228P2 (e-PCR)
- UniSTS:272019

MARC_11585-11586:1002657151:1 (e-PCR)
- UniSTS:267233

MARC_11585-11586:1007154223:1 (e-PCR)
- UniSTS:267233

EST828 (e-PCR)
- UniSTS:164068

D14S87E (e-PCR)
- UniSTS:147452

HIF1A (e-PCR)
- UniSTS:278524

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hypoxia-inducible factor 1-alpha

Names: hypoxia inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001287163.1 → NP_001274092.1 hypoxia-inducible factor 1-alpha

Status: VALIDATED

Source sequence(s)

AAEX03005770, AY455802, DN266988, DN365115, DN383577, DN395152, DN439308, DN441742

UniProtKB/TrEMBL

A0A8C0K1Y2, A0A8C0PBL6, A0A8C0QCT6, A0A8I3PI05

Related

ENSCAFP00845032269.1, ENSCAFT00845041171.1

Conserved Domains (5) summary

smart00091
Location:93 → 148

PAS; PAS domain

cd00083
Location:15 → 68

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam08778
Location:786 → 822

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam08447
Location:254 → 339

PAS_3; PAS fold

pfam11413
Location:552 → 581

HIF-1; Hypoxia-inducible factor-1