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SMAD2 SMAD family member 2 [ Canis lupus familiaris (dog) ]

Gene ID: 480144, updated on 5-Mar-2024

Summary

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Official Symbol
SMAD2provided by VGNC
Official Full Name
SMAD family member 2provided by VGNC
Primary source
VGNC:VGNC:46519
See related
Ensembl:ENSCAFG00845002338
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (43649238..43731066)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (43181631..43262778)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (43688637..43769813)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (43350952..43432066)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (43405083..43486241)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872686 Neighboring gene uncharacterized LOC119872687 Neighboring gene uncharacterized LOC111096745 Neighboring gene uncharacterized LOC102156787 Neighboring gene uncharacterized LOC111096896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development. Zhang XJ, et al. Andrologia, 2011 Aug. PMID 21486406
  2. IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation. Lin CS, et al. Cytokine, 2013 Jun. PMID 23579028

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-6 markedly decreased the nuclear concentration of a TGF-beta signaling transducer, Smad 2/3.
    Title: IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation.
  2. The temporospatial distribution of Smad2 and Smad4 proteins in testicular cells suggests that these two signalling molecules may play an important role in specific stages of testicular development and spermatogenesis.
    Title: Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    43649238..43731066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672133.1 → XP_038528061.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Related
    ENSCAFP00845003314.1, ENSCAFT00845004143.1
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. XM_038672135.1 → XP_038528063.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RNY3
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cl00056
    Location:260 → 440
    MH2; C-terminal Mad Homology 2 (MH2) domain

  3. XM_038672136.1 → XP_038528064.1  mothers against decapentaplegic homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PZC9, A0A8C0PZE1, A0A8I3MF91, A0A8I3MMS3
    Related
    ENSCAFP00845003325.1, ENSCAFT00845004155.1
    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  4. XM_038672132.1 → XP_038528060.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  5. XM_038672134.1 → XP_038528062.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    43350952..43432066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038481945.1 → XP_038337873.1  mothers against decapentaplegic homolog 2 isoform X1

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. XM_038481947.1 → XP_038337875.1  mothers against decapentaplegic homolog 2 isoform X2

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cl00056
    Location:260 → 440
    MH2; C-terminal Mad Homology 2 (MH2) domain

  3. XM_038481948.1 → XP_038337876.1  mothers against decapentaplegic homolog 2 isoform X3

    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  4. XM_038481944.1 → XP_038337872.1  mothers against decapentaplegic homolog 2 isoform X1

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  5. XM_038481946.1 → XP_038337874.1  mothers against decapentaplegic homolog 2 isoform X1

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    43405083..43486241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038607438.1 → XP_038463366.1  mothers against decapentaplegic homolog 2 isoform X1

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. XM_038607440.1 → XP_038463368.1  mothers against decapentaplegic homolog 2 isoform X2

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cl00056
    Location:260 → 440
    MH2; C-terminal Mad Homology 2 (MH2) domain

  3. XM_038607441.1 → XP_038463369.1  mothers against decapentaplegic homolog 2 isoform X3

    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  4. XM_038607437.1 → XP_038463365.1  mothers against decapentaplegic homolog 2 isoform X1

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  5. XM_038607439.1 → XP_038463367.1  mothers against decapentaplegic homolog 2 isoform X1

    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    43688637..43769813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038543327.1 → XP_038399255.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. XM_038543329.1 → XP_038399257.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RNY3
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cl00056
    Location:260 → 440
    MH2; C-terminal Mad Homology 2 (MH2) domain

  3. XM_038543330.1 → XP_038399258.1  mothers against decapentaplegic homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PZC9, A0A8C0PZE1, A0A8I3MF91, A0A8I3MMS3
    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  4. XM_038543326.1 → XP_038399254.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  5. XM_038543328.1 → XP_038399256.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    43181631..43262778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_847706.6 → XP_852799.1  mothers against decapentaplegic homolog 2 isoform X1

    See identical proteins and their annotated locations for XP_852799.1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. XM_038572971.1 → XP_038428899.1  mothers against decapentaplegic homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0RNY3
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cl00056
    Location:260 → 440
    MH2; C-terminal Mad Homology 2 (MH2) domain

  3. XM_038572973.1 → XP_038428901.1  mothers against decapentaplegic homolog 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0PZC9, A0A8C0PZE1, A0A8I3MF91, A0A8I3MMS3
    Conserved Domains (2) summary
    cd10491
    Location:8 → 142
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:236 → 426
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  4. XM_038572947.1 → XP_038428875.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  5. XM_038572963.1 → XP_038428891.1  mothers against decapentaplegic homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
    Conserved Domains (2) summary
    cd10491
    Location:8 → 172
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:266 → 456
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
Nucleotide Protein
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