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CAPN2 calpain 2 [ Canis lupus familiaris (dog) ]

Gene ID: 480118, updated on 5-Mar-2024

Summary

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Official Symbol
CAPN2provided by VGNC
Official Full Name
calpain 2provided by VGNC
Primary source
VGNC:VGNC:53334
See related
Ensembl:ENSCAFG00845013136
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (40166074..40204194, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (39815620..39853714, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (40285433..40323542, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (40007852..40045930, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (40016382..40054477, complement)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872560 Neighboring gene tumor protein p53 binding protein 2 Neighboring gene calpain 8 Neighboring gene uncharacterized LOC119872561 Neighboring gene uncharacterized LOC111096723

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-2 catalytic subunit
XP_038337464.1
XP_038398823.1
XP_038425753.1
XP_038462941.1
XP_038527666.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    40166074..40204194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038671738.1 → XP_038527666.1  calpain-2 catalytic subunit

    UniProtKB/TrEMBL
    A0A8I3NDL3, A0A8I3NF92
    Related
    ENSCAFP00845018497.1, ENSCAFT00845023560.1
    Conserved Domains (3) summary
    cd00214
    Location:354 → 510
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16199
    Location:533 → 700
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
    pfam00648
    Location:46 → 342
    Peptidase_C2; Calpain family cysteine protease

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    40007852..40045930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038481536.1 → XP_038337464.1  calpain-2 catalytic subunit

    Conserved Domains (3) summary
    cd00214
    Location:354 → 510
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16199
    Location:533 → 700
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
    pfam00648
    Location:46 → 342
    Peptidase_C2; Calpain family cysteine protease

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    40016382..40054477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038607013.1 → XP_038462941.1  calpain-2 catalytic subunit

    Conserved Domains (3) summary
    cd00214
    Location:354 → 510
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16199
    Location:533 → 700
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
    pfam00648
    Location:46 → 342
    Peptidase_C2; Calpain family cysteine protease

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    40285433..40323542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038542895.1 → XP_038398823.1  calpain-2 catalytic subunit

    UniProtKB/TrEMBL
    A0A8I3NDL3, A0A8I3NF92
    Conserved Domains (3) summary
    cd00214
    Location:354 → 510
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16199
    Location:533 → 700
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
    pfam00648
    Location:46 → 342
    Peptidase_C2; Calpain family cysteine protease

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    39815620..39853714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038569825.1 → XP_038425753.1  calpain-2 catalytic subunit

    UniProtKB/TrEMBL
    A0A8C0JS73, A0A8C0M6B8, A0A8C0SUD0, A0A8P0SIE2, A0A8P0SKP8
    Conserved Domains (3) summary
    cd00214
    Location:354 → 510
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd16199
    Location:533 → 700
    EFh_PEF_CAPN2; Penta-EF hand, calcium binding motifs, found in m-type calpain (CAPN2)
    pfam00648
    Location:46 → 342
    Peptidase_C2; Calpain family cysteine protease
Nucleotide Protein
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