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VAV3 vav guanine nucleotide exchange factor 3 [ Canis lupus familiaris (dog) ]

Gene ID: 479921, updated on 5-Mar-2024

Summary

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Official Symbol
VAV3provided by VGNC
Official Full Name
vav guanine nucleotide exchange factor 3provided by VGNC
Primary source
VGNC:VGNC:48237
See related
Ensembl:ENSCAFG00845009278
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
28
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (43923858..44276352)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (46430623..46782296)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (44059178..44411293)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (43658033..44009951)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (43628551..43981239)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102151888 Neighboring gene uncharacterized LOC119872348 Neighboring gene uncharacterized LOC119872245 Neighboring gene 60S ribosomal protein L35a-like Neighboring gene uncharacterized LOC111096507 Neighboring gene uncharacterized LOC102151934 Neighboring gene netrin G1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor VAV3
Names
vav 3 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    43923858..44276352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038669968.1 → XP_038525896.1  guanine nucleotide exchange factor VAV3 isoform X2

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl17036
    Location:791 → 834
    SH3; Src Homology 3 domain superfamily

  2. XM_038669966.1 → XP_038525894.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Related
    ENSCAFP00845012967.1, ENSCAFT00845016664.1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  3. XM_038669967.1 → XP_038525895.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  4. XM_038669969.1 → XP_038525897.1  guanine nucleotide exchange factor VAV3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MQ82, A0A8I3N858, A0A8P0TFN1
    Related
    ENSCAFP00845013485.1, ENSCAFT00845017303.1
    Conserved Domains (7) summary
    cd10407
    Location:613 → 715
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:738 → 793
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:543 → 604
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:140 → 316
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:330 → 453
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20869
    Location:453 → 511
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl00030
    Location:13 → 65
    CH_SF; calponin homology (CH) domain superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    43658033..44009951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038479884.1 → XP_038335812.1  guanine nucleotide exchange factor VAV3 isoform X1

    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  2. XM_038479885.1 → XP_038335813.1  guanine nucleotide exchange factor VAV3 isoform X2

    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl17036
    Location:791 → 834
    SH3; Src Homology 3 domain superfamily

  3. XM_038479883.1 → XP_038335811.1  guanine nucleotide exchange factor VAV3 isoform X1

    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  4. XM_038479886.1 → XP_038335814.1  guanine nucleotide exchange factor VAV3 isoform X3

    Conserved Domains (7) summary
    cd10407
    Location:613 → 715
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:738 → 793
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:543 → 604
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:140 → 316
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:330 → 453
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20869
    Location:453 → 511
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl00030
    Location:13 → 65
    CH_SF; calponin homology (CH) domain superfamily

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    43628551..43981239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038605320.1 → XP_038461248.1  guanine nucleotide exchange factor VAV3 isoform X2

    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl17036
    Location:791 → 834
    SH3; Src Homology 3 domain superfamily

  2. XM_038605318.1 → XP_038461246.1  guanine nucleotide exchange factor VAV3 isoform X1

    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  3. XM_038605319.1 → XP_038461247.1  guanine nucleotide exchange factor VAV3 isoform X1

    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  4. XM_038605321.1 → XP_038461249.1  guanine nucleotide exchange factor VAV3 isoform X3

    Conserved Domains (7) summary
    cd10407
    Location:613 → 715
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:738 → 793
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:543 → 604
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:140 → 316
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:330 → 453
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20869
    Location:453 → 511
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl00030
    Location:13 → 65
    CH_SF; calponin homology (CH) domain superfamily

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    44059178..44411293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038541166.1 → XP_038397094.1  guanine nucleotide exchange factor VAV3 isoform X2

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl17036
    Location:791 → 834
    SH3; Src Homology 3 domain superfamily

  2. XM_038541164.1 → XP_038397092.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  3. XM_038541165.1 → XP_038397093.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  4. XM_038541167.1 → XP_038397095.1  guanine nucleotide exchange factor VAV3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MQ82, A0A8I3N858, A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:613 → 715
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:738 → 793
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:543 → 604
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:140 → 316
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:330 → 453
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20869
    Location:453 → 511
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl00030
    Location:13 → 65
    CH_SF; calponin homology (CH) domain superfamily

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    46430623..46782296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038553279.1 → XP_038409207.1  guanine nucleotide exchange factor VAV3 isoform X2

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl17036
    Location:791 → 834
    SH3; Src Homology 3 domain superfamily

  2. XM_038553273.1 → XP_038409201.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  3. XM_038553277.1 → XP_038409205.1  guanine nucleotide exchange factor VAV3 isoform X1

    UniProtKB/TrEMBL
    A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:666 → 768
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:791 → 846
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:596 → 657
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:193 → 369
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:383 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21264
    Location:2 → 118
    CH_VAV3; calponin homology (CH) domain found in VAV3 protein and similar proteins
    cd20869
    Location:506 → 564
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein

  4. XM_038553283.1 → XP_038409211.1  guanine nucleotide exchange factor VAV3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0MQ82, A0A8I3N858, A0A8P0TFN1
    Conserved Domains (7) summary
    cd10407
    Location:613 → 715
    SH2_Vav3; Src homology 2 (SH2) domain found in the Vav3 proteins
    cd11978
    Location:738 → 793
    SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
    cd11981
    Location:543 → 604
    SH3_VAV3_1; First Src homology 3 domain of VAV3 protein
    cd00160
    Location:140 → 316
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:330 → 453
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd20869
    Location:453 → 511
    C1_VAV3; protein kinase C conserved region 1 (C1 domain) found in VAV3 protein
    cl00030
    Location:13 → 65
    CH_SF; calponin homology (CH) domain superfamily
Nucleotide Protein
Heading Accession and Version

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