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STUB1 STIP1 homology and U-box containing protein 1 [ Canis lupus familiaris (dog) ]

Gene ID: 479892, updated on 5-Mar-2024

Summary

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Official Symbol
STUB1provided by VGNC
Official Full Name
STIP1 homology and U-box containing protein 1provided by VGNC
Primary source
VGNC:VGNC:54073
See related
Ensembl:ENSCAFG00845026980
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 6
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (40236147..40238551, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (41157620..41160024, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (40364058..40366462, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (39924709..39927112, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (39884918..39887322, complement)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 16 Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene rhomboid like 1 Neighboring gene ras homolog family member T2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and significance of CHIP in canine mammary gland tumors. Wang H, et al. J Vet Med Sci, 2015 Nov. PMID 26156079, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CHIP
XP_038335552.1
XP_038396833.1
XP_038407127.1
XP_038460958.1
XP_038525633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    40236147..40238551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038669705.1 → XP_038525633.1  E3 ubiquitin-protein ligase CHIP

    UniProtKB/TrEMBL
    A0A8C0K769, A0A8C0N702, A0A8I3PT83
    Related
    ENSCAFP00845037301.1, ENSCAFT00845047539.1
    Conserved Domains (4) summary
    PLN03088
    Location:26 → 126
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:26 → 54
    TPR; TPR repeat [structural motif]
    cd16654
    Location:227 → 293
    RING-Ubox_CHIP; U-box domain, a modified RING finger, found in carboxyl terminus of HSP70-interacting protein (CHIP) and similar proteins
    pfam18391
    Location:142 → 225
    CHIP_TPR_N; CHIP N-terminal tetratricopeptide repeat domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    39924709..39927112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038479624.1 → XP_038335552.1  E3 ubiquitin-protein ligase CHIP

    Conserved Domains (4) summary
    PLN03088
    Location:26 → 126
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:26 → 54
    TPR; TPR repeat [structural motif]
    cd16654
    Location:227 → 293
    RING-Ubox_CHIP; U-box domain, a modified RING finger, found in carboxyl terminus of HSP70-interacting protein (CHIP) and similar proteins
    pfam18391
    Location:142 → 225
    CHIP_TPR_N; CHIP N-terminal tetratricopeptide repeat domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    39884918..39887322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038605030.1 → XP_038460958.1  E3 ubiquitin-protein ligase CHIP

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    40364058..40366462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038540905.1 → XP_038396833.1  E3 ubiquitin-protein ligase CHIP

    UniProtKB/TrEMBL
    A0A8C0K769, A0A8C0N702, A0A8I3PT83
    Conserved Domains (4) summary
    PLN03088
    Location:26 → 126
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:26 → 54
    TPR; TPR repeat [structural motif]
    cd16654
    Location:227 → 293
    RING-Ubox_CHIP; U-box domain, a modified RING finger, found in carboxyl terminus of HSP70-interacting protein (CHIP) and similar proteins
    pfam18391
    Location:142 → 225
    CHIP_TPR_N; CHIP N-terminal tetratricopeptide repeat domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    41157620..41160024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038551199.1 → XP_038407127.1  E3 ubiquitin-protein ligase CHIP

    UniProtKB/TrEMBL
    A0A8C0K769, A0A8C0N702, A0A8I3PT83
    Conserved Domains (4) summary
    PLN03088
    Location:26 → 126
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:26 → 54
    TPR; TPR repeat [structural motif]
    cd16654
    Location:227 → 293
    RING-Ubox_CHIP; U-box domain, a modified RING finger, found in carboxyl terminus of HSP70-interacting protein (CHIP) and similar proteins
    pfam18391
    Location:142 → 225
    CHIP_TPR_N; CHIP N-terminal tetratricopeptide repeat domain
Nucleotide Protein
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