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PRKCZ protein kinase C zeta [ Canis lupus familiaris (dog) ]

Gene ID: 479577, updated on 5-Mar-2024

Summary

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Official Symbol
PRKCZprovided by VGNC
Official Full Name
protein kinase C zetaprovided by VGNC
Primary source
VGNC:VGNC:44985
See related
Ensembl:ENSCAFG00845016558
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (57215092..57316595)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (57089028..57190338)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (57488367..57589745)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (57206002..57307319)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (57098518..57199838)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 74 Neighboring gene gamma-aminobutyric acid type A receptor subunit delta Neighboring gene uncharacterized LOC111095963 Neighboring gene uncharacterized LOC119871893 Neighboring gene FA core complex associated protein 20 Neighboring gene SKI proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C zeta type
XP_005620474.1
XP_005620476.1
XP_013969338.1
XP_022274635.1
XP_022274636.2
XP_038332460.1
XP_038332461.1
XP_038332462.1
XP_038332463.1
XP_038332465.1
XP_038332466.1
XP_038332467.1
XP_038332468.1
XP_038378261.1
XP_038378300.1
XP_038393604.1
XP_038393605.1
XP_038393606.1
XP_038393607.1
XP_038393608.1
XP_038393609.1
XP_038393610.1
XP_038393611.1
XP_038457768.1
XP_038457769.1
XP_038457770.1
XP_038457771.1
XP_038457772.1
XP_038457773.1
XP_038457774.1
XP_038457775.1
XP_038522342.1
XP_038522343.1
XP_038522344.1
XP_038522345.1
XP_038522346.1
XP_038522347.1
XP_038522348.1
XP_038522349.1
XP_849092.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    57215092..57316595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038666414.1 → XP_038522342.1  protein kinase C zeta type isoform X1

    UniProtKB/TrEMBL
    A0A8I3NXR9, A0A8I3P2P9
    Related
    ENSCAFP00845023385.1, ENSCAFT00845029774.1
    Conserved Domains (3) summary
    cd06404
    Location:16 → 98
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05617
    Location:235 → 591
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cl00040
    Location:129 → 183
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  2. XM_038666416.1 → XP_038522344.1  protein kinase C zeta type isoform X3

    UniProtKB/TrEMBL
    A0A8C0KBH3
    Related
    ENSCAFP00845023466.1, ENSCAFT00845029881.1
    Conserved Domains (3) summary
    cl00040
    Location:95 → 149
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl02720
    Location:2 → 64
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl21453
    Location:201 → 557
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038666415.1 → XP_038522343.1  protein kinase C zeta type isoform X2

    UniProtKB/TrEMBL
    A0A8C0KBH3
    Conserved Domains (3) summary
    cd05617
    Location:232 → 588
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cl00040
    Location:126 → 180
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl02720
    Location:16 → 95
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  4. XM_038666421.1 → XP_038522349.1  protein kinase C zeta type isoform X8

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Related
    ENSCAFP00845023493.1, ENSCAFT00845029918.1
    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  5. XM_038666417.1 → XP_038522345.1  protein kinase C zeta type isoform X4

    UniProtKB/TrEMBL
    A0A8I3NQA9, A0A8P0PKB7
    Conserved Domains (2) summary
    cd05617
    Location:173 → 529
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cd21095
    Location:67 → 121
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type

  6. XM_038666418.1 → XP_038522346.1  protein kinase C zeta type isoform X5

    UniProtKB/TrEMBL
    A0A8I3NQA9, A0A8P0PKB7
    Conserved Domains (2) summary
    cd21095
    Location:21 → 75
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
    cl21453
    Location:127 → 483
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038666419.1 → XP_038522347.1  protein kinase C zeta type isoform X6

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  8. XM_038666420.1 → XP_038522348.1  protein kinase C zeta type isoform X7

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:38 → 394
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    57206002..57307319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038476532.1 → XP_038332460.1  protein kinase C zeta type isoform X1

  2. XM_038476534.1 → XP_038332462.1  protein kinase C zeta type isoform X3

  3. XM_038476533.1 → XP_038332461.1  protein kinase C zeta type isoform X2

    Conserved Domains (3) summary
    cd05617
    Location:232 → 588
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cl00040
    Location:126 → 180
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl02720
    Location:16 → 95
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  4. XM_038476540.1 → XP_038332468.1  protein kinase C zeta type isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  5. XM_038476535.1 → XP_038332463.1  protein kinase C zeta type isoform X4

    Conserved Domains (2) summary
    cd05617
    Location:173 → 529
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cd21095
    Location:67 → 121
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type

  6. XM_038476537.1 → XP_038332465.1  protein kinase C zeta type isoform X5

    Conserved Domains (2) summary
    cd21095
    Location:21 → 75
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
    cl21453
    Location:127 → 483
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038476538.1 → XP_038332466.1  protein kinase C zeta type isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  8. XM_038476539.1 → XP_038332467.1  protein kinase C zeta type isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:38 → 394
    PKc_like; Protein Kinases, catalytic domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    57098518..57199838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038601840.1 → XP_038457768.1  protein kinase C zeta type isoform X1

  2. XM_038601842.1 → XP_038457770.1  protein kinase C zeta type isoform X3

  3. XM_038601841.1 → XP_038457769.1  protein kinase C zeta type isoform X2

    Conserved Domains (3) summary
    cd05617
    Location:232 → 588
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cl00040
    Location:126 → 180
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl02720
    Location:16 → 95
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  4. XM_038601847.1 → XP_038457775.1  protein kinase C zeta type isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  5. XM_038601843.1 → XP_038457771.1  protein kinase C zeta type isoform X4

    Conserved Domains (2) summary
    cd05617
    Location:173 → 529
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cd21095
    Location:67 → 121
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type

  6. XM_038601844.1 → XP_038457772.1  protein kinase C zeta type isoform X5

    Conserved Domains (2) summary
    cd21095
    Location:21 → 75
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
    cl21453
    Location:127 → 483
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038601845.1 → XP_038457773.1  protein kinase C zeta type isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  8. XM_038601846.1 → XP_038457774.1  protein kinase C zeta type isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:38 → 394
    PKc_like; Protein Kinases, catalytic domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    57488367..57589745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038537676.1 → XP_038393604.1  protein kinase C zeta type isoform X1

    UniProtKB/TrEMBL
    A0A8C0QAW8, A0A8P0T684, A0A8P0TMI4

  2. XM_038537678.1 → XP_038393606.1  protein kinase C zeta type isoform X3

    UniProtKB/TrEMBL
    A0A8C0KBH3

  3. XM_038537677.1 → XP_038393605.1  protein kinase C zeta type isoform X2

    UniProtKB/TrEMBL
    A0A8C0KBH3
    Conserved Domains (3) summary
    cd05617
    Location:232 → 588
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cl00040
    Location:126 → 180
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl02720
    Location:16 → 95
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  4. XM_038537683.1 → XP_038393611.1  protein kinase C zeta type isoform X8

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  5. XM_038537679.1 → XP_038393607.1  protein kinase C zeta type isoform X4

    UniProtKB/TrEMBL
    A0A8I3NQA9, A0A8P0PKB7
    Conserved Domains (2) summary
    cd05617
    Location:173 → 529
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cd21095
    Location:67 → 121
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type

  6. XM_038537680.1 → XP_038393608.1  protein kinase C zeta type isoform X5

    UniProtKB/TrEMBL
    A0A8I3NQA9, A0A8P0PKB7
    Conserved Domains (2) summary
    cd21095
    Location:21 → 75
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
    cl21453
    Location:127 → 483
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038537681.1 → XP_038393609.1  protein kinase C zeta type isoform X6

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  8. XM_038537682.1 → XP_038393610.1  protein kinase C zeta type isoform X7

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:38 → 394
    PKc_like; Protein Kinases, catalytic domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    57089028..57190338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_843999.6 → XP_849092.1  protein kinase C zeta type isoform X1

    UniProtKB/TrEMBL
    A0A8C0QAW8, A0A8P0T684, A0A8P0TMI4
    Conserved Domains (3) summary
    cd06404
    Location:16 → 98
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05617
    Location:235 → 591
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    pfam00130
    Location:131 → 180
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. XM_005620419.4 → XP_005620476.1  protein kinase C zeta type isoform X3

    UniProtKB/TrEMBL
    A0A8C0KBH3
    Conserved Domains (3) summary
    pfam00130
    Location:97 → 146
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:2 → 64
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    cl21453
    Location:201 → 557
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038522333.1 → XP_038378261.1  protein kinase C zeta type isoform X2

    UniProtKB/TrEMBL
    A0A8C0KBH3
    Conserved Domains (3) summary
    cd05617
    Location:232 → 588
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cl00040
    Location:126 → 180
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
    cl02720
    Location:16 → 95
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  4. XM_038522372.1 → XP_038378300.1  protein kinase C zeta type isoform X8

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  5. XM_014113863.2 → XP_013969338.1  protein kinase C zeta type isoform X4

    UniProtKB/TrEMBL
    A0A8I3NQA9, A0A8P0PKB7
    Conserved Domains (2) summary
    cd05617
    Location:173 → 529
    STKc_aPKC_zeta; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta
    cd21095
    Location:67 → 121
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type

  6. XM_005620417.4 → XP_005620474.1  protein kinase C zeta type isoform X5

    UniProtKB/TrEMBL
    A0A8I3NQA9, A0A8P0PKB7
    Conserved Domains (2) summary
    cd21095
    Location:21 → 75
    C1_aPKC_zeta; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) zeta type
    cl21453
    Location:127 → 483
    PKc_like; Protein Kinases, catalytic domain

  7. XM_022418927.2 → XP_022274635.1  protein kinase C zeta type isoform X6

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:52 → 408
    PKc_like; Protein Kinases, catalytic domain

  8. XM_022418928.2 → XP_022274636.2  protein kinase C zeta type isoform X7

    UniProtKB/TrEMBL
    A0A8I3NY03, A0A8P0TN21
    Conserved Domains (1) summary
    cl21453
    Location:38 → 394
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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