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PDE4B phosphodiesterase 4B [ Canis lupus familiaris (dog) ]

Gene ID: 479540, updated on 5-Mar-2024

Summary

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Official Symbol
PDE4Bprovided by VGNC
Official Full Name
phosphodiesterase 4Bprovided by VGNC
Primary source
VGNC:VGNC:44354
See related
Ensembl:ENSCAFG00845028786
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (44251621..44793357, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (44186161..44663652, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (44405153..44947628, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (44216433..44758769, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (44161847..44703948, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095919 Neighboring gene SH3GL interacting endocytic adaptor 1 Neighboring gene uncharacterized LOC111095920 Neighboring gene uncharacterized LOC102156117 Neighboring gene uncharacterized LOC111095923 Neighboring gene uncharacterized LOC111095922 Neighboring gene uncharacterized LOC111095924 Neighboring gene uncharacterized LOC102155947 Neighboring gene ADP/ATP translocase 2-like Neighboring gene uncharacterized LOC111095921 Neighboring gene ATP synthase subunit d, mitochondrial-like Neighboring gene uncharacterized LOC102156371 Neighboring gene leptin receptor Neighboring gene uncharacterized LOC111096111

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Names
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
XP_003434692.1
XP_013969180.1
XP_013969181.1
XP_022274421.1
XP_038331964.1
XP_038331965.1
XP_038331966.1
XP_038331967.1
XP_038331968.1
XP_038331969.1
XP_038331970.1
XP_038331971.1
XP_038374914.1
XP_038374937.1
XP_038393150.1
XP_038393151.1
XP_038393152.1
XP_038393153.1
XP_038393154.1
XP_038393155.1
XP_038393156.1
XP_038393157.1
XP_038457278.1
XP_038457279.1
XP_038457280.1
XP_038457281.1
XP_038457282.1
XP_038457283.1
XP_038457284.1
XP_038457285.1
XP_038521844.1
XP_038521845.1
XP_038521846.1
XP_038521847.1
XP_038521848.1
XP_038521849.1
XP_038521850.1
XP_038521851.1
XP_536678.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    44251621..44793357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038665916.1 → XP_038521844.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
    Related
    ENSCAFP00845040013.1, ENSCAFT00845051038.1
    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. XM_038665917.1 → XP_038521845.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. XM_038665920.1 → XP_038521848.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

    UniProtKB/TrEMBL
    A0A8C0L722
    Conserved Domains (2) summary
    pfam00233
    Location:314 → 555
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:74 → 190
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. XM_038665918.1 → XP_038521846.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0M947, A0A8I3Q1G8
    Related
    ENSCAFP00845040044.1, ENSCAFT00845051078.1
    Conserved Domains (2) summary
    pfam00233
    Location:391 → 632
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:151 → 267
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  5. XM_038665919.1 → XP_038521847.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    UniProtKB/TrEMBL
    A0A8C0L722
    Conserved Domains (2) summary
    pfam00233
    Location:329 → 570
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:89 → 205
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  6. XM_038665922.1 → XP_038521850.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

    Conserved Domains (2) summary
    pfam00233
    Location:186 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 62
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. XM_038665921.1 → XP_038521849.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIV5, A0A8I3PZX6
    Related
    ENSCAFP00845040064.1, ENSCAFT00845051098.1
    Conserved Domains (2) summary
    pfam00233
    Location:206 → 447
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:12 → 82
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  8. XM_038665923.1 → XP_038521851.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

    UniProtKB/TrEMBL
    A0A8C0L7P5, A0A8C0M3Z2, A0A8I3SBZ4
    Related
    ENSCAFP00845040242.1, ENSCAFT00845051302.1
    Conserved Domains (2) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    44216433..44758769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038476036.1 → XP_038331964.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. XM_038476037.1 → XP_038331965.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. XM_038476040.1 → XP_038331968.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

    Conserved Domains (2) summary
    pfam00233
    Location:314 → 555
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:74 → 190
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. XM_038476038.1 → XP_038331966.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

    Conserved Domains (2) summary
    pfam00233
    Location:391 → 632
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:151 → 267
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  5. XM_038476039.1 → XP_038331967.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    Conserved Domains (2) summary
    pfam00233
    Location:329 → 570
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:89 → 205
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  6. XM_038476042.1 → XP_038331970.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

    Conserved Domains (2) summary
    pfam00233
    Location:186 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 62
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. XM_038476041.1 → XP_038331969.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

    Conserved Domains (2) summary
    pfam00233
    Location:206 → 447
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:12 → 82
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  8. XM_038476043.1 → XP_038331971.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

    Conserved Domains (2) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    44161847..44703948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038601350.1 → XP_038457278.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. XM_038601351.1 → XP_038457279.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. XM_038601354.1 → XP_038457282.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

    Conserved Domains (2) summary
    pfam00233
    Location:314 → 555
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:74 → 190
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. XM_038601352.1 → XP_038457280.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

    Conserved Domains (2) summary
    pfam00233
    Location:391 → 632
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:151 → 267
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  5. XM_038601353.1 → XP_038457281.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    Conserved Domains (2) summary
    pfam00233
    Location:329 → 570
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:89 → 205
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  6. XM_038601356.1 → XP_038457284.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

    Conserved Domains (2) summary
    pfam00233
    Location:186 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 62
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. XM_038601355.1 → XP_038457283.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

    Conserved Domains (2) summary
    pfam00233
    Location:206 → 447
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:12 → 82
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  8. XM_038601357.1 → XP_038457285.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

    Conserved Domains (2) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    44405153..44947628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038537222.1 → XP_038393150.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. XM_038537223.1 → XP_038393151.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. XM_038537226.1 → XP_038393154.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

    UniProtKB/TrEMBL
    A0A8C0L722
    Conserved Domains (2) summary
    pfam00233
    Location:314 → 555
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:74 → 190
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. XM_038537224.1 → XP_038393152.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0M947, A0A8I3Q1G8
    Conserved Domains (2) summary
    pfam00233
    Location:391 → 632
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:151 → 267
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  5. XM_038537225.1 → XP_038393153.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

    UniProtKB/TrEMBL
    A0A8C0L722
    Conserved Domains (2) summary
    pfam00233
    Location:329 → 570
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:89 → 205
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  6. XM_038537228.1 → XP_038393156.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

    Conserved Domains (2) summary
    pfam00233
    Location:186 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 62
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. XM_038537227.1 → XP_038393155.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIV5, A0A8I3PZX6
    Conserved Domains (2) summary
    pfam00233
    Location:206 → 447
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:12 → 82
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  8. XM_038537229.1 → XP_038393157.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

    UniProtKB/TrEMBL
    A0A8C0L7P5, A0A8C0M3Z2, A0A8I3SBZ4
    Conserved Domains (2) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    44186161..44663652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003434644.5 → XP_003434692.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    See identical proteins and their annotated locations for XP_003434692.1

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. XM_038518986.1 → XP_038374914.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIS1, A0A8I3SBV2
    Conserved Domains (2) summary
    pfam00233
    Location:406 → 647
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 282
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. XM_022418713.2 → XP_022274421.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

    UniProtKB/TrEMBL
    A0A8C0L722
    Conserved Domains (2) summary
    pfam00233
    Location:314 → 555
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:74 → 190
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. XM_536678.7 → XP_536678.3  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0M947, A0A8I3Q1G8
    Conserved Domains (2) summary
    pfam00233
    Location:391 → 632
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:151 → 267
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  5. XM_038519009.1 → XP_038374937.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6

    Conserved Domains (2) summary
    pfam00233
    Location:186 → 427
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1 → 62
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  6. XM_014113705.3 → XP_013969180.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

    UniProtKB/TrEMBL
    A0A8C0L722, A0A8C0QIV5, A0A8I3PZX6
    Conserved Domains (2) summary
    pfam00233
    Location:206 → 447
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:12 → 82
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  7. XM_014113706.3 → XP_013969181.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X7

    UniProtKB/TrEMBL
    A0A8C0L7P5, A0A8C0M3Z2, A0A8I3SBZ4
    Conserved Domains (2) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
Nucleotide Protein
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