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ATM ATM serine/threonine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 479450, updated on 5-Mar-2024

Summary

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Official Symbol
ATMprovided by VGNC
Official Full Name
ATM serine/threonine kinaseprovided by VGNC
Primary source
VGNC:VGNC:38233
See related
Ensembl:ENSCAFG00845003472
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
64
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (24211375..24326057, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (24107778..24222696, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (24218488..24333125, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (24258890..24373424, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (24160300..24274920, complement)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene protein O-glucosyltransferase 3 Neighboring gene chromosome 5 C11orf65 homolog Neighboring gene uncharacterized LOC111095857 Neighboring gene 60S ribosomal protein L31-like Neighboring gene uncharacterized LOC111095856 Neighboring gene nuclear protein, coactivator of histone transcription Neighboring gene acetyl-CoA acetyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM. Flassig RJ, et al. Mol Biosyst, 2014 Jul. PMID 24833308
  2. Complete sequencing of full-length canine ataxia telangiectasia mutated mRNA and characterization of its putative promoter. Gentilini F, et al. Vet Immunol Immunopathol, 2009 Apr 15. PMID 19131117
  3. Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death. Luo Y, et al. J Virol, 2011 Jan. PMID 21047968, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine-protein kinase ATM
Names
ataxia telangiectasia mutated (includes complementation groups A, C and D)
NP_001124300.1
XP_038520030.1
XP_038520031.1
XP_038520032.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130828.1 → NP_001124300.1  serine-protein kinase ATM

    See identical proteins and their annotated locations for NP_001124300.1

    Status: PROVISIONAL

    Source sequence(s)
    EU770574
    UniProtKB/TrEMBL
    A0A8C0NK96, A0A8P0SR22, B3VMJ2
    Related
    ENSCAFP00845004935.1, ENSCAFT00845006206.1
    Conserved Domains (4) summary
    cd05171
    Location:2683 → 2962
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:2096 → 2489
    FAT; FAT domain
    pfam02260
    Location:3026 → 3055
    FATC; FATC domain
    pfam11640
    Location:11 → 165
    TAN; Telomere-length maintenance and DNA damage repair

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    24211375..24326057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664102.1 → XP_038520030.1  serine-protein kinase ATM isoform X1

    UniProtKB/TrEMBL
    A0A8C0NK96, A0A8I3RRE6
    Conserved Domains (4) summary
    cd05171
    Location:2683 → 2962
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:2096 → 2489
    FAT; FAT domain
    pfam02260
    Location:3026 → 3055
    FATC; FATC domain
    pfam11640
    Location:8 → 165
    TAN; Telomere-length maintenance and DNA damage repair

  2. XM_038664103.1 → XP_038520031.1  serine-protein kinase ATM isoform X2

    UniProtKB/TrEMBL
    A0A8C0NK96
    Conserved Domains (3) summary
    cd05171
    Location:2107 → 2386
    PIKKc_ATM; Catalytic domain of Ataxia Telangiectasia Mutated
    pfam02259
    Location:1520 → 1913
    FAT; FAT domain
    pfam02260
    Location:2450 → 2479
    FATC; FATC domain

  3. XM_038664104.1 → XP_038520032.1  serine-protein kinase ATM isoform X3

    Conserved Domains (1) summary
    pfam11640
    Location:8 → 165
    TAN; Telomere-length maintenance and DNA damage repair

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    24258890..24373424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    24160300..24274920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    24218488..24333125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    24107778..24222696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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