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HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 479344, updated on 5-Mar-2024

Summary

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Official Symbol
HMGCS1provided by VGNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 1provided by VGNC
Primary source
VGNC:VGNC:103681
See related
Ensembl:ENSCAFG00845001633
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (67130232..67144820)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (66394617..66415022)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (67551264..67571669)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (66884796..66905197)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (67014391..67034791)

Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene MICOS complex subunit MIC26-like Neighboring gene C-C motif chemokine ligand 28 Neighboring gene uncharacterized LOC119871545 Neighboring gene uncharacterized LOC119874752 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene zinc finger protein 131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Names
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
XP_005619401.1
XP_022273571.1
XP_038329998.1
XP_038329999.1
XP_038330000.1
XP_038330001.1
XP_038354707.1
XP_038391100.1
XP_038391101.1
XP_038391102.1
XP_038391103.1
XP_038455393.1
XP_038455394.1
XP_038455395.1
XP_038455396.1
XP_038519706.1
XP_038519707.1
XP_536483.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051808.1 Reference ROS_Cfam_1.0

    Range
    67130232..67144820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038663779.1 → XP_038519707.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8C0LD95, A0A8I3MM03, A0A8P0PLH2, A0A8P0SMM6
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  2. XM_038663778.1 → XP_038519706.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8C0LD95, A0A8I3MM03, A0A8P0PLH2, A0A8P0SMM6
    Related
    ENSCAFP00845002255.1, ENSCAFT00845002833.1
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049264.1 Alternate UMICH_Zoey_3.1

    Range
    66884796..66905197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038474072.1 → XP_038330000.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  2. XM_038474073.1 → XP_038330001.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  3. XM_038474071.1 → XP_038329999.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  4. XM_038474070.1 → XP_038329998.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

    Range
    67014391..67034791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038599467.1 → XP_038455395.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  2. XM_038599468.1 → XP_038455396.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  3. XM_038599466.1 → XP_038455394.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X3

    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  4. XM_038599465.1 → XP_038455393.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X3

    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

    Range
    67551264..67571669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038535174.1 → XP_038391102.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8C0LD95, A0A8I3MM03, A0A8P0PLH2, A0A8P0SMM6
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  2. XM_038535175.1 → XP_038391103.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8C0LD95, A0A8I3MM03, A0A8P0PLH2, A0A8P0SMM6
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  3. XM_038535173.1 → XP_038391101.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X4

    UniProtKB/TrEMBL
    A0A8P0PLH2
    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  4. XM_038535172.1 → XP_038391100.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X4

    UniProtKB/TrEMBL
    A0A8P0PLH2
    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    66394617..66415022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_536483.6 → XP_536483.3  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_536483.3

    UniProtKB/TrEMBL
    A0A8C0LD95, A0A8I3MM03, A0A8P0PLH2, A0A8P0SMM6
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  2. XM_005619344.2 → XP_005619401.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    See identical proteins and their annotated locations for XP_005619401.1

    UniProtKB/TrEMBL
    A0A8C0LD95, A0A8I3MM03, A0A8P0PLH2, A0A8P0SMM6
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  3. XM_022417863.2 → XP_022273571.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X5

    UniProtKB/TrEMBL
    A0A8P0PLH2
    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

  4. XM_038498779.1 → XP_038354707.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X5

    UniProtKB/TrEMBL
    A0A8P0PLH2
    Conserved Domains (1) summary
    TIGR01833
    Location:55 → 511
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
Nucleotide Protein
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