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HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase [ Canis lupus familiaris (dog) ]

Gene ID: 479182, updated on 5-Mar-2024

Summary

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Official Symbol
HMGCRprovided by VGNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA reductaseprovided by VGNC
Primary source
VGNC:VGNC:41714
See related
Ensembl:ENSCAFG00845011849
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See HMGCR in Genome Data Viewer
Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (30898455..30920631, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (32211759..32233728, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (31177224..31199407, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (30828548..30850686, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (30798860..30820987, complement)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene ceramide transporter 1 Neighboring gene uncharacterized LOC111095175 Neighboring gene uncharacterized LOC119871179 Neighboring gene U6 spliceosomal RNA Neighboring gene ankyrin repeat domain 31 Neighboring gene metallothionein-2E-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
3-hydroxy-3-methylglutaryl-Coenzyme A reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    30898455..30920631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038661035.1 → XP_038516963.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NLM4, A0A8P0NBK5
    Related
    ENSCAFP00845016677.1, ENSCAFT00845021211.1
    Conserved Domains (1) summary
    TIGR00920
    Location:46 → 933
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  2. XM_038661038.1 → XP_038516966.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X3

    UniProtKB/TrEMBL
    A0A8C0LMV8, A0A8I3NLM4, A0A8P0NBK5
    Conserved Domains (1) summary
    TIGR00920
    Location:1 → 888
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  3. XM_038661037.1 → XP_038516965.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2

    UniProtKB/TrEMBL
    A0A8C0PWR9, A0A8I3NLM4, A0A8I3NME2, A0A8P0NBK5
    Related
    ENSCAFP00845016550.1, ENSCAFT00845021051.1
    Conserved Domains (1) summary
    TIGR00920
    Location:17 → 904
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    30828548..30850686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471609.1 → XP_038327537.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    Conserved Domains (1) summary
    TIGR00920
    Location:46 → 933
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  2. XM_038471611.1 → XP_038327539.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X3

    Conserved Domains (1) summary
    TIGR00920
    Location:1 → 888
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  3. XM_038471610.1 → XP_038327538.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2

    Conserved Domains (1) summary
    TIGR00920
    Location:17 → 904
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    30798860..30820987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596825.1 → XP_038452753.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    Conserved Domains (1) summary
    TIGR00920
    Location:46 → 933
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  2. XM_038596827.1 → XP_038452755.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X3

    Conserved Domains (1) summary
    TIGR00920
    Location:1 → 888
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  3. XM_038596826.1 → XP_038452754.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2

    Conserved Domains (1) summary
    TIGR00920
    Location:17 → 904
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    31177224..31199407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532540.1 → XP_038388468.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NLM4, A0A8P0NBK5
    Conserved Domains (1) summary
    TIGR00920
    Location:46 → 933
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  2. XM_038532542.1 → XP_038388470.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X3

    UniProtKB/TrEMBL
    A0A8C0LMV8, A0A8I3NLM4, A0A8P0NBK5
    Conserved Domains (1) summary
    TIGR00920
    Location:1 → 888
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  3. XM_038532541.1 → XP_038388469.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2

    UniProtKB/TrEMBL
    A0A8C0PWR9, A0A8I3NLM4, A0A8I3NME2, A0A8P0NBK5
    Conserved Domains (1) summary
    TIGR00920
    Location:17 → 904
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    32211759..32233728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022416792.2 → XP_022272500.2  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1

    UniProtKB/TrEMBL
    A0A8I3NLM4, A0A8P0NBK5
    Conserved Domains (1) summary
    TIGR00920
    Location:46 → 933
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  2. XM_038472480.1 → XP_038328408.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X3

    UniProtKB/TrEMBL
    A0A8C0LMV8, A0A8I3NLM4, A0A8P0NBK5
    Conserved Domains (1) summary
    TIGR00920
    Location:1 → 888
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase

  3. XM_038472470.1 → XP_038328398.1  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X2

    UniProtKB/TrEMBL
    A0A8C0PWR9, A0A8I3NLM4, A0A8I3NME2, A0A8P0NBK5
    Conserved Domains (1) summary
    TIGR00920
    Location:17 → 904
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Nucleotide Protein
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