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RASA1 RAS p21 protein activator 1 [ Canis lupus familiaris (dog) ]

Gene ID: 479158, updated on 5-Mar-2024

Summary

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Official Symbol
RASA1provided by VGNC
Official Full Name
RAS p21 protein activator 1provided by VGNC
Primary source
VGNC:VGNC:45359
See related
Ensembl:ENSCAFG00845018838
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 3 NC_051807.1 (20976854..21085576, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 3 NC_006585.4 (22433878..22542367, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 3 NC_049224.1 (21202248..21310549, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 3 NC_049263.1 (20947976..21056165, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 3 NC_049744.1 (20910527..21018703, complement)

Chromosome 3 - NC_051807.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L37a-like Neighboring gene uncharacterized LOC111095149 Neighboring gene cyclin H Neighboring gene 60S ribosomal protein L4-like Neighboring gene glutathione S-transferase P-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin. Kimura T, et al. J Biol Chem, 2006 Apr 14. PMID 16423831

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RIN2 connects Ras to Rab5 in the HGF-induced endocytosis of E-cadherin [RIN2]
    Title: Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ras GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051807.1 Reference ROS_Cfam_1.0

    Range
    20976854..21085576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038660885.1 → XP_038516813.1  ras GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUL8, A0A8C0MKC1, A0A8I3PDZ1
    Related
    ENSCAFP00845026578.1, ENSCAFT00845033962.1
    Conserved Domains (6) summary
    cd08400
    Location:568 → 693
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:138 → 241
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:327 → 403
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:258 → 316
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:691 → 1022
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:466 → 553
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049263.1 Alternate UMICH_Zoey_3.1

    Range
    20947976..21056165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471467.1 → XP_038327395.1  ras GTPase-activating protein 1 isoform X1

    Conserved Domains (6) summary
    cd08400
    Location:568 → 693
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:138 → 241
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:327 → 403
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:258 → 316
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:691 → 1022
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:466 → 553
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049744.1 Alternate UNSW_CanFamBas_1.0

    Range
    20910527..21018703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596677.1 → XP_038452605.1  ras GTPase-activating protein 1 isoform X1

    Conserved Domains (6) summary
    cd08400
    Location:568 → 693
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:138 → 241
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:327 → 403
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:258 → 316
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:691 → 1022
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:466 → 553
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049224.1 Alternate UU_Cfam_GSD_1.0

    Range
    21202248..21310549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532397.1 → XP_038388325.1  ras GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JUL8, A0A8C0MKC1, A0A8I3PDZ1
    Conserved Domains (6) summary
    cd08400
    Location:568 → 693
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:138 → 241
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:327 → 403
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:258 → 316
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:691 → 1022
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:466 → 553
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006585.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    22433878..22542367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471120.1 → XP_038327048.1  ras GTPase-activating protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JUL8, A0A8C0MKC1, A0A8I3PDZ1
    Conserved Domains (6) summary
    cd08400
    Location:568 → 693
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:138 → 241
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:327 → 403
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:258 → 316
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:691 → 1022
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:466 → 553
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

RNA

  1. XR_005322602.1 RNA Sequence

Nucleotide Protein
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