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GAD1 glutamate decarboxylase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 478794, updated on 5-Mar-2024

Summary

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Official Symbol
GAD1provided by VGNC
Official Full Name
glutamate decarboxylase 1provided by VGNC
Primary source
VGNC:VGNC:41067
See related
Ensembl:ENSCAFG00845025996
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
GAD67
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 36
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (15474678..15516842)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (15364114..15403437)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (15664544..15703870)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (15565032..15604314)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (15552796..15592193)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene glutamate rich 2 Neighboring gene uncharacterized LOC111094195 Neighboring gene uncharacterized LOC119867827 Neighboring gene U1 small nuclear ribonucleoprotein C-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparison of glutamic acid decarboxylase 67 immunoreactive neurons in the hippocampal CA1 region at various age stages in dogs. Hwang IK, et al. Neurosci Lett, 2008 Feb 6. PMID 18166269
  2. Comparison of GAD65 and 67 immunoreactivity in the lumbar spinal cord between young adult and aged dogs. Lee HJ, et al. Neurochem Res, 2011 Mar. PMID 21193958
  3. Sequences of canine glutamate decarboxylase (GAD) 1 and GAD2 genes, and variation of their genetic polymorphisms among five dog breeds. Arata S, et al. J Vet Med Sci, 2008 Oct. PMID 18981669

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that the distribution of GAD65-immunoreactive structures is different from GAD67-immunoreactive structures and that their immunoreactivity in the aged dogs is much higher than the adult dogs.
    Title: Comparison of GAD65 and 67 immunoreactivity in the lumbar spinal cord between young adult and aged dogs.
  2. GAD67 immunoreactive neurons were significantly decreased region with age in dog.
    Title: Comparison of glutamic acid decarboxylase 67 immunoreactive neurons in the hippocampal CA1 region at various age stages in dogs.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables glutamate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in gamma-aminobutyric acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
glutamate decarboxylase 1
Names
67 kDa glutamic acid decarboxylase
GAD-67
NP_001091012.1
XP_038302631.1
XP_038302632.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097543.1 → NP_001091012.1  glutamate decarboxylase 1

    See identical proteins and their annotated locations for NP_001091012.1

    Status: PROVISIONAL

    Source sequence(s)
    AB261624
    UniProtKB/Swiss-Prot
    A0PA85
    UniProtKB/TrEMBL
    A0A8C0JRB0
    Conserved Domains (1) summary
    pfam00282
    Location:144 → 518
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    15474678..15516842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446703.1 → XP_038302631.1  glutamate decarboxylase 1 isoform X1

    UniProtKB/Swiss-Prot
    A0PA85
    UniProtKB/TrEMBL
    A0A8C0JRB0
    Related
    ENSCAFP00845036025.1, ENSCAFT00845045887.1
    Conserved Domains (1) summary
    pfam00282
    Location:144 → 518
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  2. XM_038446704.1 → XP_038302632.1  glutamate decarboxylase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0TYC0, A0A8I3PXE2
    Related
    ENSCAFP00845036296.1, ENSCAFT00845046223.1
    Conserved Domains (1) summary
    pfam00282
    Location:135 → 509
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    15565032..15604314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    15552796..15592193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    15664544..15703870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    15364114..15403437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0PA85.1 GenPept UniProtKB/Swiss-Prot:A0PA85

Gene LinkOut

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