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GRB14 growth factor receptor bound protein 14 [ Canis lupus familiaris (dog) ]

Gene ID: 478770, updated on 5-Mar-2024

Summary

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Official Symbol
GRB14provided by VGNC
Official Full Name
growth factor receptor bound protein 14provided by VGNC
Primary source
VGNC:VGNC:41471
See related
Ensembl:ENSCAFG00845015206
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 36
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (9844049..9975461, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (9856214..9987580, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (10011150..10142536, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (9855062..9986361, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (9897060..10011627, complement)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094286 Neighboring gene fidgetin, microtubule severing factor Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102152414 Neighboring gene cordon-bleu WH2 repeat protein like 1 Neighboring gene uncharacterized LOC102152220 Neighboring gene complement component 1 Q subcomponent-binding protein, mitochondrial-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth factor receptor-bound protein 14; LOW QUALITY PROTEIN: growth factor receptor-bound protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    9844049..9975461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446918.1 → XP_038302846.1  growth factor receptor-bound protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JU42, A0A8I3NWV9, A0A8P0NCU1
    Related
    ENSCAFP00845021392.1, ENSCAFT00845027193.1
    Conserved Domains (4) summary
    cd10414
    Location:380 → 487
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:177 → 298
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:54 → 138
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:317 → 361
    BPS; BPS (Between PH and SH2)

  2. XM_038446917.1 → XP_038302845.1  growth factor receptor-bound protein 14 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JUP7, A0A8C0NLB8, A0A8I3NM36
    Related
    ENSCAFP00845021429.1, ENSCAFT00845027237.1
    Conserved Domains (4) summary
    cd10414
    Location:441 → 548
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:238 → 359
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:115 → 199
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:378 → 422
    BPS; BPS (Between PH and SH2)

  3. XM_038446920.1 → XP_038302848.1  growth factor receptor-bound protein 14 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JU42
    Conserved Domains (4) summary
    cd10414
    Location:346 → 453
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:143 → 264
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:20 → 104
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:283 → 327
    BPS; BPS (Between PH and SH2)

  4. XM_038446919.1 → XP_038302847.1  growth factor receptor-bound protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JU42
    Conserved Domains (4) summary
    cd10414
    Location:359 → 466
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:156 → 277
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:34 → 117
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:296 → 340
    BPS; BPS (Between PH and SH2)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    9855062..9986361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038520993.1 → XP_038376921.1  growth factor receptor-bound protein 14 isoform X1

  2. XM_038520992.1 → XP_038376920.1  growth factor receptor-bound protein 14 isoform X4

  3. XM_038520995.1 → XP_038376923.1  growth factor receptor-bound protein 14 isoform X3

  4. XM_038520994.1 → XP_038376922.1  growth factor receptor-bound protein 14 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    9897060..10011627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038649106.1 → XP_038505034.1  LOW QUALITY PROTEIN: growth factor receptor-bound protein 14 isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    10011150..10142536 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038584687.1 → XP_038440615.1  growth factor receptor-bound protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JU42, A0A8I3NWV9, A0A8P0NCU1
    Conserved Domains (4) summary
    cd10414
    Location:380 → 487
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:177 → 298
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:54 → 138
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:317 → 361
    BPS; BPS (Between PH and SH2)

  2. XM_038584686.1 → XP_038440614.1  growth factor receptor-bound protein 14 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JUP7, A0A8C0NLB8, A0A8I3NM36
    Conserved Domains (4) summary
    cd10414
    Location:441 → 548
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:238 → 359
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:115 → 199
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:378 → 422
    BPS; BPS (Between PH and SH2)

  3. XM_038584689.1 → XP_038440617.1  growth factor receptor-bound protein 14 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JU42
    Conserved Domains (4) summary
    cd10414
    Location:346 → 453
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:143 → 264
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:20 → 104
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:283 → 327
    BPS; BPS (Between PH and SH2)

  4. XM_038584688.1 → XP_038440616.1  growth factor receptor-bound protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JU42
    Conserved Domains (4) summary
    cd10414
    Location:359 → 466
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:156 → 277
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:34 → 117
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:296 → 340
    BPS; BPS (Between PH and SH2)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    9856214..9987580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014110703.3 → XP_013966178.1  growth factor receptor-bound protein 14 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JU42, A0A8I3NWV9, A0A8P0NCU1
    Conserved Domains (4) summary
    cd10414
    Location:380 → 487
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:177 → 298
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:54 → 138
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:317 → 361
    BPS; BPS (Between PH and SH2)

  2. XM_038463379.1 → XP_038319307.1  growth factor receptor-bound protein 14 isoform X4

    UniProtKB/TrEMBL
    A0A8C0JUP7, A0A8C0NLB8, A0A8I3NM36
    Conserved Domains (4) summary
    cd10414
    Location:441 → 548
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:238 → 359
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:115 → 199
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:378 → 422
    BPS; BPS (Between PH and SH2)

  3. XM_014110705.3 → XP_013966180.1  growth factor receptor-bound protein 14 isoform X3

    UniProtKB/TrEMBL
    A0A8C0JU42
    Conserved Domains (4) summary
    cd10414
    Location:346 → 453
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:143 → 264
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:20 → 104
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:283 → 327
    BPS; BPS (Between PH and SH2)

  4. XM_022414663.2 → XP_022270371.1  growth factor receptor-bound protein 14 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JU42
    Conserved Domains (4) summary
    cd10414
    Location:359 → 466
    SH2_Grb14; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 14 (Grb14) proteins
    cd01259
    Location:156 → 277
    PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
    cd16139
    Location:34 → 117
    RA_GRB14; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 14
    pfam08947
    Location:296 → 340
    BPS; BPS (Between PH and SH2)
Nucleotide Protein
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