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NR4A2 nuclear receptor subfamily 4 group A member 2 [ Canis lupus familiaris (dog) ]

Gene ID: 478754, updated on 5-Mar-2024

Summary

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Official Symbol
NR4A2provided by VGNC
Official Full Name
nuclear receptor subfamily 4 group A member 2provided by VGNC
Primary source
VGNC:VGNC:43955
See related
Ensembl:ENSCAFG00845025175
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 36
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 36 NC_051840.1 (2664920..2682769, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 36 NC_006618.4 (2678764..2696690, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 36 NC_049257.1 (2763654..2781495, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 36 NC_049296.1 (2663962..2681849, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 36 NC_049777.1 (2724009..2741835, complement)

Chromosome 36 - NC_051840.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867790 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene uncharacterized LOC119867809 Neighboring gene uncharacterized LOC111094232 Neighboring gene transfer RNA alanine (anticodon CGC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to corticotropin-releasing hormone stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dopaminergic neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nuclear receptor subfamily 4 group A member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051840.1 Reference ROS_Cfam_1.0

    Range
    2664920..2682769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446763.1 → XP_038302691.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Related
    ENSCAFP00845034833.1, ENSCAFT00845044455.1
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  2. XM_038446767.1 → XP_038302695.1  nuclear receptor subfamily 4 group A member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SFK7
    Conserved Domains (2) summary
    cd07071
    Location:298 → 535
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198 → 272
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  3. XM_038446766.1 → XP_038302694.1  nuclear receptor subfamily 4 group A member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SFK7
    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:361 → 580
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  4. XM_038446762.1 → XP_038302690.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  5. XM_038446765.1 → XP_038302693.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  6. XM_038446764.1 → XP_038302692.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  7. XM_038446768.1 → XP_038302696.1  nuclear receptor subfamily 4 group A member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KAJ4, A0A8C0YX67, A0A8I3PXP3
    Related
    ENSCAFP00845034900.1, ENSCAFT00845044541.1
    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:367 → 477
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RNA

  1. XR_005307646.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049296.1 Alternate UMICH_Zoey_3.1

    Range
    2663962..2681849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038520864.1 → XP_038376792.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  2. XM_038520868.1 → XP_038376796.1  nuclear receptor subfamily 4 group A member 2 isoform X3

    Conserved Domains (2) summary
    cd07071
    Location:298 → 535
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198 → 272
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  3. XM_038520867.1 → XP_038376795.1  nuclear receptor subfamily 4 group A member 2 isoform X2

    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:361 → 580
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  4. XM_038520863.1 → XP_038376791.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  5. XM_038520866.1 → XP_038376794.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  6. XM_038520865.1 → XP_038376793.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  7. XM_038520869.1 → XP_038376797.1  nuclear receptor subfamily 4 group A member 2 isoform X4

    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:367 → 477
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RNA

  1. XR_005350640.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049777.1 Alternate UNSW_CanFamBas_1.0

    Range
    2724009..2741835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038648951.1 → XP_038504879.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  2. XM_038648955.1 → XP_038504883.1  nuclear receptor subfamily 4 group A member 2 isoform X3

    Conserved Domains (2) summary
    cd07071
    Location:298 → 535
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198 → 272
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  3. XM_038648954.1 → XP_038504882.1  nuclear receptor subfamily 4 group A member 2 isoform X2

    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:361 → 580
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  4. XM_038648950.1 → XP_038504878.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  5. XM_038648953.1 → XP_038504881.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  6. XM_038648952.1 → XP_038504880.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  7. XM_038648956.1 → XP_038504884.1  nuclear receptor subfamily 4 group A member 2 isoform X4

    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:367 → 477
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RNA

  1. XR_005418260.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049257.1 Alternate UU_Cfam_GSD_1.0

    Range
    2763654..2781495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038584533.1 → XP_038440461.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  2. XM_038584537.1 → XP_038440465.1  nuclear receptor subfamily 4 group A member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SFK7
    Conserved Domains (2) summary
    cd07071
    Location:298 → 535
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198 → 272
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  3. XM_038584536.1 → XP_038440464.1  nuclear receptor subfamily 4 group A member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SFK7
    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:361 → 580
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  4. XM_038584532.1 → XP_038440460.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  5. XM_038584535.1 → XP_038440463.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  6. XM_038584534.1 → XP_038440462.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  7. XM_038584538.1 → XP_038440466.1  nuclear receptor subfamily 4 group A member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KAJ4, A0A8C0YX67, A0A8I3PXP3
    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:367 → 477
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RNA

  1. XR_005384553.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006618.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    2678764..2696690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038463441.1 → XP_038319369.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  2. XM_038463443.1 → XP_038319371.1  nuclear receptor subfamily 4 group A member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0SFK7
    Conserved Domains (2) summary
    cd07071
    Location:298 → 535
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:198 → 272
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  3. XM_038463442.1 → XP_038319370.1  nuclear receptor subfamily 4 group A member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0SFK7
    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:361 → 580
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

  4. XM_535920.7 → XP_535920.2  nuclear receptor subfamily 4 group A member 2 isoform X1

    See identical proteins and their annotated locations for XP_535920.2

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  5. XM_014110865.3 → XP_013966340.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  6. XM_022414761.2 → XP_022270469.1  nuclear receptor subfamily 4 group A member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KBE2, A0A8C0MMA8, A0A8C0SFK7, A0A8I3PJX5
    Conserved Domains (2) summary
    cd07071
    Location:361 → 598
    NR_LBD_Nurr1; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

  7. XM_014110866.3 → XP_013966341.1  nuclear receptor subfamily 4 group A member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0KAJ4, A0A8C0YX67, A0A8I3PXP3
    Conserved Domains (2) summary
    cd06969
    Location:261 → 335
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
    cl11397
    Location:367 → 477
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RNA

  1. XR_001315359.3 RNA Sequence

Nucleotide Protein
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