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PRKCI protein kinase C iota [ Canis lupus familiaris (dog) ]

Gene ID: 478686, updated on 5-Mar-2024

Summary

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Official Symbol
PRKCIprovided by VGNC
Official Full Name
protein kinase C iotaprovided by VGNC
Primary source
VGNC:VGNC:44982
See related
Ensembl:ENSCAFG00845022436
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 34
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (34847084..34921270)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (43779787..43851893)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (35025008..35098029)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (34792870..34864800)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (34760842..34834497)

Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 160 Neighboring gene polyhomeotic homolog 3 Neighboring gene uncharacterized LOC111093892 Neighboring gene uncharacterized LOC102153364 Neighboring gene SKI like proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion. Gopalakrishnan S, et al. Am J Physiol Cell Physiol, 2007 Mar. PMID 16928777
  2. Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells. Hong SH, et al. Vet Comp Oncol, 2011 Sep. PMID 21848623, Free PMC Article
  3. KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells. Yoshihama Y, et al. Curr Biol, 2011 Apr 26. PMID 21497093
  4. PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Lu R, et al. Mol Biol Cell, 2015 Apr 15. PMID 25694446, Free PMC Article
  5. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. Ishiuchi T, et al. Nat Cell Biol, 2011 Jun 19. PMID 21685893

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PKCiota binds to Rab14 and that PKCiota requires Rab14 for its correct distribution in cells. As with Rab14, PKCiota protects claudin-2 from lysosomal degradation and, in consequence, modulates epithelial barrier.
    Title: PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels.
  2. This study demonstrated, using four newly established canine osteosarcoma cell lines, that protein kinase C (PKC) alpha, PKC gamma, and PKC iota are responsible for the phosphorylation of ezrin and cell migration in canine osteosarcoma cells.
    Title: Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells.
  3. Report a willin(FRMD6)/Par3-aPKC-ROCK pathway that controls epithelial apical morphology.
    Title: Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.
  4. The results strongly support the notion that KIBRA regulates epithelial cell polarity by suppressing apical exocytosis through direct inhibition of aPKC kinase activity in the PAR3-aPKC-PAR6 complex.
    Title: KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.
  5. These data indicate that aPKC signaling is impaired during ATP depletion, participates in tight junction disassembly during cell injury and is important for tight junction reassembly during recovery.
    Title: aPKC-PAR complex dysfunction and tight junction disassembly in renal epithelial cells during ATP depletion.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C iota type; LOW QUALITY PROTEIN: protein kinase C iota type
XP_022269846.1
XP_022269847.1
XP_038301978.1
XP_038301979.1
XP_038301980.1
XP_038376168.1
XP_038439798.1
XP_038439799.1
XP_038439800.1
XP_038504213.1
XP_038504214.1
XP_038504215.1
XP_535855.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051838.1 Reference ROS_Cfam_1.0

    Range
    34847084..34921270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038446050.1 → XP_038301978.1  protein kinase C iota type isoform X1

    UniProtKB/TrEMBL
    A0A8C0JRC6, A0A8C0YW41, A0A8P0T1U2
    Related
    ENSCAFP00845031161.1, ENSCAFT00845039787.1
    Conserved Domains (3) summary
    cd06404
    Location:26 → 108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:233 → 596
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:139 → 193
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  2. XM_038446052.1 → XP_038301980.1  protein kinase C iota type isoform X2

    UniProtKB/TrEMBL
    A0A8C0PZR7, A0A8I3PGZ0, A0A8P0T1U2
    Related
    ENSCAFP00845031404.1, ENSCAFT00845040102.1
    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  3. XM_038446051.1 → XP_038301979.1  protein kinase C iota type isoform X2

    UniProtKB/TrEMBL
    A0A8C0PZR7, A0A8I3PGZ0, A0A8P0T1U2
    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049294.1 Alternate UMICH_Zoey_3.1

    Range
    34792870..34864800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038520240.1 → XP_038376168.1  LOW QUALITY PROTEIN: protein kinase C iota type isoform X1

    Conserved Domains (3) summary
    cd06404
    Location:26 → 108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:233 → 596
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:139 → 193
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

    Range
    34760842..34834497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038648285.1 → XP_038504213.1  protein kinase C iota type isoform X1

    Conserved Domains (3) summary
    cd06404
    Location:26 → 108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:233 → 596
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:139 → 193
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  2. XM_038648287.1 → XP_038504215.1  protein kinase C iota type isoform X2

    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  3. XM_038648286.1 → XP_038504214.1  protein kinase C iota type isoform X2

    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

    Range
    35025008..35098029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583870.1 → XP_038439798.1  protein kinase C iota type isoform X1

    UniProtKB/TrEMBL
    A0A8C0JRC6, A0A8C0YW41, A0A8P0T1U2
    Conserved Domains (3) summary
    cd06404
    Location:26 → 108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:233 → 596
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:139 → 193
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  2. XM_038583872.1 → XP_038439800.1  protein kinase C iota type isoform X2

    UniProtKB/TrEMBL
    A0A8C0PZR7, A0A8I3PGZ0, A0A8P0T1U2
    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  3. XM_038583871.1 → XP_038439799.1  protein kinase C iota type isoform X2

    UniProtKB/TrEMBL
    A0A8C0PZR7, A0A8I3PGZ0, A0A8P0T1U2
    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    43779787..43851893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_535855.7 → XP_535855.5  protein kinase C iota type isoform X1

    UniProtKB/TrEMBL
    A0A8C0JRC6, A0A8C0YW41, A0A8P0T1U2
    Conserved Domains (3) summary
    cd06404
    Location:26 → 108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:233 → 596
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:139 → 193
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  2. XM_022414139.2 → XP_022269847.1  protein kinase C iota type isoform X2

    UniProtKB/TrEMBL
    A0A8C0PZR7, A0A8I3PGZ0, A0A8P0T1U2
    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family

  3. XM_022414138.2 → XP_022269846.1  protein kinase C iota type isoform X2

    UniProtKB/TrEMBL
    A0A8C0PZR7, A0A8I3PGZ0, A0A8P0T1U2
    Conserved Domains (3) summary
    cd06404
    Location:1 → 72
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:197 → 560
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    cd20794
    Location:103 → 157
    C1_aPKC; protein kinase C conserved region 1 (C1 domain) found in the atypical protein kinase C (aPKC) family
Nucleotide Protein
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