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DVL3 dishevelled segment polarity protein 3 [ Canis lupus familiaris (dog) ]

Gene ID: 478650, updated on 5-Mar-2024

Summary

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Official Symbol
DVL3provided by VGNC
Official Full Name
dishevelled segment polarity protein 3provided by VGNC
Primary source
VGNC:VGNC:40139
See related
Ensembl:ENSCAFG00845026259
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 34
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 34 NC_051838.1 (16961718..16975817)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 34 NC_006616.4 (21140844..21154943)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 34 NC_049255.1 (17225218..17241675)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 34 NC_049294.1 (16999057..17013143)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 34 NC_049775.1 (16995018..17011464)

Chromosome 34 - NC_051838.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867498 Neighboring gene TSSK6-activating co-chaperone protein-like Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene uncharacterized LOC111093832 Neighboring gene adaptor related protein complex 2 subunit mu 1 Neighboring gene ATP binding cassette subfamily F member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
segment polarity protein dishevelled homolog DVL-3
Names
dishevelled, dsh homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051838.1 Reference ROS_Cfam_1.0

    Range
    16961718..16975817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038445695.1 → XP_038301623.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF5, A0A8C0TMQ9, A0A8I3PTY8, A0A8I3PXQ3
    Related
    ENSCAFP00845036546.1, ENSCAFT00845046553.1
    Conserved Domains (5) summary
    smart00021
    Location:1 → 82
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413 → 496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:92 → 245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500 → 706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049294.1 Alternate UMICH_Zoey_3.1

    Range
    16999057..17013143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038519884.1 → XP_038375812.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

    Conserved Domains (5) summary
    smart00021
    Location:1 → 82
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413 → 496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:92 → 245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500 → 706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049775.1 Alternate UNSW_CanFamBas_1.0

    Range
    16995018..17011464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038647928.1 → XP_038503856.1  segment polarity protein dishevelled homolog DVL-3 isoform X2

  2. XM_038647929.1 → XP_038503857.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

    Conserved Domains (5) summary
    smart00021
    Location:1 → 82
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413 → 496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:92 → 245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500 → 706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049255.1 Alternate UU_Cfam_GSD_1.0

    Range
    17225218..17241675
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038583521.1 → XP_038439449.1  segment polarity protein dishevelled homolog DVL-3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0TQZ5, A0A8I3PXQ3, A0A8P0NDZ5

  2. XM_038583522.1 → XP_038439450.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF5, A0A8C0TMQ9, A0A8I3PTY8, A0A8I3PXQ3
    Conserved Domains (5) summary
    smart00021
    Location:1 → 82
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413 → 496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:92 → 245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500 → 706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006616.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21140844..21154943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_535822.7 → XP_535822.2  segment polarity protein dishevelled homolog DVL-3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JPF5, A0A8C0TMQ9, A0A8I3PTY8, A0A8I3PXQ3
    Conserved Domains (5) summary
    smart00021
    Location:1 → 82
    DAX; Domain present in Dishevelled and axin
    cd00992
    Location:247 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04438
    Location:413 → 496
    DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
    pfam02377
    Location:92 → 245
    Dishevelled; Dishevelled specific domain
    pfam12316
    Location:500 → 706
    Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
Nucleotide Protein
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