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ADAM10 ADAM metallopeptidase domain 10 [ Canis lupus familiaris (dog) ]

Gene ID: 478321, updated on 5-Mar-2024

Summary

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Official Symbol
ADAM10provided by VGNC
Official Full Name
ADAM metallopeptidase domain 10provided by VGNC
Primary source
VGNC:VGNC:59103
See related
Ensembl:ENSCAFG00845015520
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 30
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 30 NC_051834.1 (23770904..23899036, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 30 NC_006612.4 (23577513..23704721, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 30 NC_049251.1 (23923628..24051939, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 30 NC_049290.1 (23696156..23822891, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 30 NC_049771.1 (23781555..23908752, complement)

Chromosome 30 - NC_051834.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093294 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC119866901 Neighboring gene lipase C, hepatic type Neighboring gene THUMP domain-containing protein 3-like Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing. Sarasa L, et al. Neuroscience, 2010 Dec 29. PMID 20875843

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
ADAM 10
a disintegrin and metalloprotease domain 10
XP_038298387.1
XP_038317222.1
XP_038372845.1
XP_038436468.1
XP_038500780.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051834.1 Reference ROS_Cfam_1.0

    Range
    23770904..23899036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038442459.1 → XP_038298387.1  disintegrin and metalloproteinase domain-containing protein 10

    UniProtKB/TrEMBL
    A0A8C0TYF2, M1VKS2
    Related
    ENSCAFP00845021903.1, ENSCAFT00845027829.1
    Conserved Domains (3) summary
    smart00050
    Location:465 → 544
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:219 → 458
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46 → 156
    Pep_M12B_propep; Reprolysin family propeptide

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049290.1 Alternate UMICH_Zoey_3.1

    Range
    23696156..23822891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038516917.1 → XP_038372845.1  disintegrin and metalloproteinase domain-containing protein 10

    Conserved Domains (3) summary
    smart00050
    Location:465 → 544
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:219 → 458
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46 → 156
    Pep_M12B_propep; Reprolysin family propeptide

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049771.1 Alternate UNSW_CanFamBas_1.0

    Range
    23781555..23908752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038644852.1 → XP_038500780.1  disintegrin and metalloproteinase domain-containing protein 10

    Conserved Domains (3) summary
    smart00050
    Location:465 → 544
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:219 → 458
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46 → 156
    Pep_M12B_propep; Reprolysin family propeptide

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049251.1 Alternate UU_Cfam_GSD_1.0

    Range
    23923628..24051939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038580540.1 → XP_038436468.1  disintegrin and metalloproteinase domain-containing protein 10

    UniProtKB/TrEMBL
    A0A8C0TYF2, M1VKS2
    Conserved Domains (3) summary
    smart00050
    Location:465 → 544
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:219 → 458
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46 → 156
    Pep_M12B_propep; Reprolysin family propeptide

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    23577513..23704721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038461294.1 → XP_038317222.1  disintegrin and metalloproteinase domain-containing protein 10

    UniProtKB/TrEMBL
    A0A8C0TYF2, M1VKS2
    Conserved Domains (3) summary
    smart00050
    Location:465 → 544
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:219 → 458
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:46 → 156
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein
Heading Accession and Version

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