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MTOR mechanistic target of rapamycin kinase [ Canis lupus familiaris (dog) ]

Gene ID: 478232, updated on 9-Mar-2024

Summary

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Official Symbol
MTORprovided by VGNC
Official Full Name
mechanistic target of rapamycin kinaseprovided by VGNC
Primary source
VGNC:VGNC:43490
See related
Ensembl:ENSCAFG00845002541
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
FRAP1
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Genomic context

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See MTOR in Genome Data Viewer
Location:
chromosome: 2
Exon count:
54
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (85486181..85601386)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (81349286..81469352)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (84293674..84413764)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (82229433..82349483)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (83231190..83351242)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870068 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene serine/threonine-protein kinase mTOR-like Neighboring gene uncharacterized LOC119870512 Neighboring gene U6 spliceosomal RNA Neighboring gene angiopoietin like 7 Neighboring gene uncharacterized LOC119870513 Neighboring gene exosome component 10 Neighboring gene uncharacterized LOC106558426

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histological and Immunohistochemical Evaluation of Phosphorylated Mechanistic Target of Rapamycin in Canine Skin Tumours. Mathew R, et al. J Comp Pathol, 2021 Apr. PMID 33894879
  2. In vitro effects of PI3K/mTOR inhibition in canine hemangiosarcoma. Pyuen AA, et al. PLoS One, 2018. PMID 30011343, Free PMC Article
  3. Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signalling pathway in canine haemangiomas and haemangiosarcomas. Murai A, et al. J Comp Pathol, 2012 Nov. PMID 22789858
  4. Mammalian target of rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines. Zhang W, et al. Exp Neurol, 2012 Feb. PMID 22177999
  5. p-mTOR, p-4EBP-1 and eIF4E expression in canine prostatic carcinoma. Rivera-Calderón LG, et al. Res Vet Sci, 2019 Feb. PMID 30476726

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histological and Immunohistochemical Evaluation of Phosphorylated Mechanistic Target of Rapamycin in Canine Skin Tumours.
    Title: Histological and Immunohistochemical Evaluation of Phosphorylated Mechanistic Target of Rapamycin in Canine Skin Tumours.
  2. These data suggest that p-mTOR and eIF4E expression is positively correlated with GS in canine PC, similar to the pattern in humans. More studies of the mTOR/4EBP1/eIF4E pathway should be performed to identify possible correlations of the proteins involved with clinical and pathologic findings in canine PC and the roles of these proteins as therapeutic targets for the treatment of canine PC.
    Title: p-mTOR, p-4EBP-1 and eIF4E expression in canine prostatic carcinoma.
  3. VDC-597 demonstrated additive antiproliferative effects when combined with doxorubicin. These results suggest that inhibitors of the PI3K/mTOR pathway may act against multiple components of the neoplastic process, including proliferation/apoptosis.
    Title: In vitro effects of PI3K/mTOR inhibition in canine hemangiosarcoma.
  4. mTOR is overexpressed in human osteoarthritis (OA) cartilage as well as mouse and dog experimental OA. Upregulation of mTOR expression co-relates with increased chondrocyte apoptosis and reduced expression of key autophagy genes during OA.
    Title: Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis.
  5. The present findings suggest that the mTORC2/Akt/4E-BP1 pathway, regulated independently of mTORC1, may be important for targeting therapy in canine hemangio-sarcomas.
    Title: Immunohistochemical analysis of the Akt/mTOR/4E-BP1 signalling pathway in canine haemangiomas and haemangiosarcomas.
  6. The mTOR molecular signaling pathway plays a significant role mediating the cerebral vasospasm that follows subarachnoid hemorrhage brain injury.
    Title: Mammalian target of rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines.
  7. Laminin-111 increases NT3 production through Akt, mTOR, and p70S6K pathways via integrin beta1 in adipose-derived stem cells cultured in neural induction media.
    Title: Role of laminin-111 in neurotrophin-3 production of canine adipose-derived stem cells: involvement of Akt, mTOR, and p70S6K.
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Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase mTOR
Names
FK506 binding protein 12-rapamycin associated protein 1
XP_005618060.1
XP_038327044.1
XP_038387959.1
XP_038452222.1
XP_038516296.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    85486181..85601386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038660368.1 → XP_038516296.1  serine/threonine-protein kinase mTOR isoform X1

    UniProtKB/TrEMBL
    A0A8I3MJG3
    Related
    ENSCAFP00845003647.1, ENSCAFT00845004565.1
    Conserved Domains (2) summary
    COG5032
    Location:87 → 2274
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:379 → 405
    HEAT; HEAT repeat [structural motif]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    82229433..82349483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471116.1 → XP_038327044.1  serine/threonine-protein kinase mTOR isoform X2

    Conserved Domains (2) summary
    COG5032
    Location:368 → 2550
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:655 → 681
    HEAT; HEAT repeat [structural motif]

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    83231190..83351242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596294.1 → XP_038452222.1  serine/threonine-protein kinase mTOR isoform X3

    Conserved Domains (2) summary
    COG5032
    Location:368 → 2550
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:655 → 681
    HEAT; HEAT repeat [structural motif]

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    84293674..84413764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038532031.1 → XP_038387959.1  serine/threonine-protein kinase mTOR isoform X4

    UniProtKB/TrEMBL
    A0A8C0NQB2, A0A8P0NI49
    Conserved Domains (2) summary
    COG5032
    Location:368 → 2550
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:655 → 681
    HEAT; HEAT repeat [structural motif]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    81349286..81469352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005618003.4 → XP_005618060.1  serine/threonine-protein kinase mTOR isoform X5

    See identical proteins and their annotated locations for XP_005618060.1

    UniProtKB/TrEMBL
    A0A8C0NQB2, A0A8P0NI49
    Conserved Domains (2) summary
    COG5032
    Location:368 → 2550
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    sd00044
    Location:655 → 681
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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