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RBL2 RB transcriptional corepressor like 2 [ Canis lupus familiaris (dog) ]

Gene ID: 478127, updated on 5-Mar-2024

Summary

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Official Symbol
RBL2provided by VGNC
Official Full Name
RB transcriptional corepressor like 2provided by VGNC
Primary source
VGNC:VGNC:45403
See related
Ensembl:ENSCAFG00845003441
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See RBL2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (62805721..62857135, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (58897038..58948437, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (61532307..61583705, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (59629354..59680520, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (60649922..60701093, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870323 Neighboring gene AKT interacting protein Neighboring gene hsc70-interacting protein-like Neighboring gene 60S ribosomal protein L5-like Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like Neighboring gene U4 spliceosomal RNA Neighboring gene chromodomain helicase DNA binding protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
retinoblastoma-like protein 2
Names
retinoblastoma-like 2 (p130)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    62805721..62857135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038659344.1 → XP_038515272.1  retinoblastoma-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MJQ4, A0A8C0MJZ3, A0A8I3N5E1
    Related
    ENSCAFP00845004860.1, ENSCAFT00845006112.1
    Conserved Domains (5) summary
    pfam01858
    Location:417 → 608
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104 → 236
    DUF3452; Domain of unknown function (DUF3452)
    cd00043
    Location:47 → 134
    CYCLIN_SF; Cyclin box fold superfamily
    cd20606
    Location:834 → 1023
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:699 → 837
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  2. XM_038659345.1 → XP_038515273.1  retinoblastoma-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JPB8
    Conserved Domains (4) summary
    pfam01858
    Location:286 → 477
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:1 → 105
    DUF3452; Domain of unknown function (DUF3452)
    cd20606
    Location:703 → 892
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:568 → 706
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    59629354..59680520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038470215.1 → XP_038326143.1  retinoblastoma-like protein 2 isoform X1

    Conserved Domains (5) summary
    pfam01858
    Location:417 → 608
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104 → 236
    DUF3452; Domain of unknown function (DUF3452)
    cd00043
    Location:47 → 134
    CYCLIN_SF; Cyclin box fold superfamily
    cd20606
    Location:834 → 1023
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:699 → 837
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  2. XM_038470216.1 → XP_038326144.1  retinoblastoma-like protein 2 isoform X2

    Conserved Domains (4) summary
    pfam01858
    Location:286 → 477
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:1 → 105
    DUF3452; Domain of unknown function (DUF3452)
    cd20606
    Location:703 → 892
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:568 → 706
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    60649922..60701093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038595255.1 → XP_038451183.1  retinoblastoma-like protein 2 isoform X1

    Conserved Domains (5) summary
    pfam01858
    Location:417 → 608
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104 → 236
    DUF3452; Domain of unknown function (DUF3452)
    cd00043
    Location:47 → 134
    CYCLIN_SF; Cyclin box fold superfamily
    cd20606
    Location:834 → 1023
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:699 → 837
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  2. XM_038595256.1 → XP_038451184.1  retinoblastoma-like protein 2 isoform X2

    Conserved Domains (4) summary
    pfam01858
    Location:286 → 477
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:1 → 105
    DUF3452; Domain of unknown function (DUF3452)
    cd20606
    Location:703 → 892
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:568 → 706
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    61532307..61583705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038531039.1 → XP_038386967.1  retinoblastoma-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MJQ4, A0A8C0MJZ3, A0A8I3N5E1
    Conserved Domains (5) summary
    pfam01858
    Location:417 → 608
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104 → 236
    DUF3452; Domain of unknown function (DUF3452)
    cd00043
    Location:47 → 134
    CYCLIN_SF; Cyclin box fold superfamily
    cd20606
    Location:834 → 1023
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:699 → 837
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  2. XM_038531040.1 → XP_038386968.1  retinoblastoma-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JPB8
    Conserved Domains (4) summary
    pfam01858
    Location:286 → 477
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:1 → 105
    DUF3452; Domain of unknown function (DUF3452)
    cd20606
    Location:703 → 892
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:568 → 706
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58897038..58948437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_535303.5 → XP_535303.2  retinoblastoma-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MJQ4, A0A8C0MJZ3, A0A8I3N5E1
    Conserved Domains (5) summary
    pfam01858
    Location:417 → 608
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:104 → 236
    DUF3452; Domain of unknown function (DUF3452)
    cd00043
    Location:47 → 134
    CYCLIN_SF; Cyclin box fold superfamily
    cd20606
    Location:834 → 1023
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:699 → 837
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

  2. XM_038461032.1 → XP_038316960.1  retinoblastoma-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0JPB8
    Conserved Domains (4) summary
    pfam01858
    Location:286 → 477
    RB_A; Retinoblastoma-associated protein A domain
    pfam11934
    Location:1 → 105
    DUF3452; Domain of unknown function (DUF3452)
    cd20606
    Location:703 → 892
    CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins
    cl41773
    Location:568 → 706
    SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
Nucleotide Protein
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