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MAP3K1 mitogen-activated protein kinase kinase kinase 1 [ Canis lupus familiaris (dog) ]

Gene ID: 478061, updated on 5-Mar-2024

Summary

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Official Symbol
MAP3K1provided by VGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 1provided by VGNC
Primary source
VGNC:VGNC:42966
See related
Ensembl:ENSCAFG00845028679
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (44400091..44478773)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (40979535..41058128)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (43100342..43179022)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (41477057..41555639)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (42280433..42359075)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092268 Neighboring gene dual specificity protein phosphatase 5-like Neighboring gene uncharacterized LOC106557898 Neighboring gene small nucleolar RNA U3 Neighboring gene SET domain containing 9 Neighboring gene MIER family member 3 Neighboring gene uncharacterized LOC119870239

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 1
XP_038325748.1
XP_038386556.1
XP_038450802.1
XP_038514848.1
XP_535240.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    44400091..44478773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038658920.1 → XP_038514848.1  mitogen-activated protein kinase kinase kinase 1

    UniProtKB/TrEMBL
    A0A8C0LEW6, A0A8C0LJE1, A0A8C0N237, A0A8I3PX84
    Related
    ENSCAFP00845039758.1, ENSCAFT00845050716.1
    Conserved Domains (2) summary
    cd06630
    Location:1237 → 1504
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:440 → 495
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    41477057..41555639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038469820.1 → XP_038325748.1  mitogen-activated protein kinase kinase kinase 1

    Conserved Domains (2) summary
    cd06630
    Location:1237 → 1504
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:440 → 495
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    42280433..42359075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038594874.1 → XP_038450802.1  mitogen-activated protein kinase kinase kinase 1

    Conserved Domains (2) summary
    cd06630
    Location:1237 → 1504
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:440 → 495
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    43100342..43179022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038530628.1 → XP_038386556.1  mitogen-activated protein kinase kinase kinase 1

    UniProtKB/TrEMBL
    A0A8C0LEW6, A0A8C0LJE1, A0A8C0N237, A0A8I3PX84
    Conserved Domains (2) summary
    cd06630
    Location:1237 → 1504
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:440 → 495
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    40979535..41058128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_535240.7 → XP_535240.4  mitogen-activated protein kinase kinase kinase 1

    UniProtKB/TrEMBL
    A0A8C0LEW6, A0A8C0LJE1, A0A8C0N237, A0A8I3PX84
    Conserved Domains (2) summary
    cd06630
    Location:1237 → 1504
    STKc_MEKK1; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1
    cd16494
    Location:440 → 495
    RING-CH-C4HC3_ZSWM2; RING-CH finger, H2 subclass (C4HC3-type), found in zinc finger SWIM domain-containing protein 2 (ZSWIM2) and similar proteins
Nucleotide Protein
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