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ITGB1 integrin subunit beta 1 [ Canis lupus familiaris (dog) ]

Gene ID: 477956, updated on 5-Mar-2024

Summary

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Official Symbol
ITGB1provided by VGNC
Official Full Name
integrin subunit beta 1provided by VGNC
Primary source
VGNC:VGNC:42136
See related
Ensembl:ENSCAFG00845002947
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ITGB1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (4006817..4053107)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (3811003..3857059)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (3939078..3985170)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (3785306..3831383)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (3819236..3865356)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene neuropilin 1 Neighboring gene uncharacterized LOC106560035 Neighboring gene uncharacterized LOC119870087 Neighboring gene rRNA-processing protein FCF1 homolog Neighboring gene coiled-coil domain containing 7 Neighboring gene uncharacterized LOC119875646

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Galectin-3 modulates the polarized surface delivery of β1-integrin in epithelial cells. Hönig E, et al. J Cell Sci, 2018 Jun 11. PMID 29748377
  2. Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism. Hunter MP, et al. Am J Physiol Cell Physiol, 2010 Jul. PMID 20457839, Free PMC Article
  3. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Kong T, et al. Mol Biol Cell, 2009 Nov. PMID 19776354, Free PMC Article
  4. Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV. Friedrichs J, et al. J Biol Chem, 2008 Nov 21. PMID 18806266
  5. A discoidin domain receptor 1/SHP-2 signaling complex inhibits alpha2beta1-integrin-mediated signal transducers and activators of transcription 1/3 activation and cell migration. Wang CZ, et al. Mol Biol Cell, 2006 Jun. PMID 16611743, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Galectin-3 targets newly synthesized beta1-integrin to the apical membrane and promotes apical delivery of beta1-integrin internalized from the basolateral membrane.
    Title: Galectin-3 modulates the polarized surface delivery of β1-integrin in epithelial cells.
  2. Pak1-induced branching morphogenesis in 3D MDCK cell culture requires PIX binding and beta1-integrin signaling.
    Title: Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanism.
  3. Data demonstrate that G alpha 12 inhibits interaction of MDCK cells with collagen-I, the major ligand for alpha2 beta1 integrin, and regulates epithelial cell spreading and migration necessary for normal tubulogenesis.
    Title: G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis.
  4. galectin-3 influences integrin alpha(2)beta(1)-mediated adhesion complex formation by altering receptor clustering
    Title: Galectin-3 regulates integrin alpha2beta1-mediated adhesion to collagen-I and -IV.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-X3-C chemokine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables collagen binding involved in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fibronectin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
integrin beta-1
Names
integrin beta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    4006817..4053107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038658027.1 → XP_038513955.1  integrin beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N387, A0A8C0PYR6, A0A8I3MMM0, A0A8I3MMP8
    Related
    ENSCAFP00845004324.1, ENSCAFT00845005439.1
    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_038658028.1 → XP_038513956.1  integrin beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDT4, A0A8C0PYR6, A0A8I3MMM0
    Related
    ENSCAFP00845004285.1, ENSCAFT00845005381.1
    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    3785306..3831383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038469003.1 → XP_038324931.1  integrin beta-1 isoform X1

    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_038469004.1 → XP_038324932.1  integrin beta-1 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    3819236..3865356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038593949.1 → XP_038449877.1  integrin beta-1 isoform X1

    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_038593950.1 → XP_038449878.1  integrin beta-1 isoform X2

    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    3939078..3985170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038529709.1 → XP_038385637.1  integrin beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N387, A0A8C0PYR6, A0A8I3MMM0, A0A8I3MMP8
    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_038529710.1 → XP_038385638.1  integrin beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDT4, A0A8C0PYR6, A0A8I3MMM0
    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3811003..3857059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038455730.1 → XP_038311658.1  integrin beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N387, A0A8C0PYR6, A0A8I3MMM0, A0A8I3MMP8
    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_038455731.1 → XP_038311659.1  integrin beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KDT4, A0A8C0PYR6, A0A8I3MMM0
    Conserved Domains (4) summary
    smart00187
    Location:34 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:755 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    NF033759
    Location:472 → 650
    exchanger_TraA; outer membrane exchange protein TraA
Nucleotide Protein
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