U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LYN LYN proto-oncogene, Src family tyrosine kinase [ Canis lupus familiaris (dog) ]

Gene ID: 477886, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
LYNprovided by VGNC
Official Full Name
LYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
Primary source
VGNC:VGNC:42882
See related
Ensembl:ENSCAFG00845026886
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LYN in Genome Data Viewer
Location:
chromosome: 29
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 29 NC_051833.1 (7407120..7522482)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 29 NC_006611.4 (7646390..7761519)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 29 NC_049250.1 (7830951..7946216)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 29 NC_049289.1 (7421443..7536515)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 29 NC_049770.1 (7554220..7669329)

Chromosome 29 - NC_051833.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 68 Neighboring gene trimethylguanosine synthase 1 Neighboring gene uncharacterized LOC119866667 Neighboring gene uncharacterized LOC111093247 Neighboring gene neuregulin 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Lepanto P, et al. Cell Microbiol, 2011 Aug. PMID 21615664, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein kinase Lyn
Names
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
XP_005638056.1
XP_038297121.1
XP_038297122.1
XP_038297123.1
XP_038297124.1
XP_038316732.1
XP_038316733.1
XP_038371697.1
XP_038371698.1
XP_038371699.1
XP_038371700.1
XP_038435265.1
XP_038435266.1
XP_038435267.1
XP_038435268.1
XP_038499505.1
XP_038499506.1
XP_038499507.1
XP_038499508.1
XP_535078.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051833.1 Reference ROS_Cfam_1.0

    Range
    7407120..7522482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038441194.1 → XP_038297122.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0TXP6, A0A8I3Q113
    Related
    ENSCAFP00845037195.1, ENSCAFT00845047404.1
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  2. XM_038441196.1 → XP_038297124.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS17, A0A8C0TT90, A0A8C0TXP6, A0A8I3SAH4
    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  3. XM_038441193.1 → XP_038297121.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0TXP6, A0A8I3Q113
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  4. XM_038441195.1 → XP_038297123.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS17, A0A8C0TT90, A0A8C0TXP6, A0A8I3SAH4
    Related
    ENSCAFP00845037302.1, ENSCAFT00845047540.1
    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049289.1 Alternate UMICH_Zoey_3.1

    Range
    7421443..7536515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038515770.1 → XP_038371698.1  tyrosine-protein kinase Lyn isoform X1

    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  2. XM_038515772.1 → XP_038371700.1  tyrosine-protein kinase Lyn isoform X2

    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  3. XM_038515769.1 → XP_038371697.1  tyrosine-protein kinase Lyn isoform X1

    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  4. XM_038515771.1 → XP_038371699.1  tyrosine-protein kinase Lyn isoform X2

    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049770.1 Alternate UNSW_CanFamBas_1.0

    Range
    7554220..7669329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038643578.1 → XP_038499506.1  tyrosine-protein kinase Lyn isoform X1

    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  2. XM_038643580.1 → XP_038499508.1  tyrosine-protein kinase Lyn isoform X2

    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  3. XM_038643577.1 → XP_038499505.1  tyrosine-protein kinase Lyn isoform X1

    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  4. XM_038643579.1 → XP_038499507.1  tyrosine-protein kinase Lyn isoform X2

    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049250.1 Alternate UU_Cfam_GSD_1.0

    Range
    7830951..7946216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038579338.1 → XP_038435266.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0TXP6, A0A8I3Q113
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  2. XM_038579340.1 → XP_038435268.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS17, A0A8C0TT90, A0A8C0TXP6, A0A8I3SAH4
    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  3. XM_038579337.1 → XP_038435265.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0TXP6, A0A8I3Q113
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  4. XM_038579339.1 → XP_038435267.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS17, A0A8C0TT90, A0A8C0TXP6, A0A8I3SAH4
    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006611.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    7646390..7761519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038460804.1 → XP_038316732.1  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0TXP6, A0A8I3Q113
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  2. XM_038460805.1 → XP_038316733.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS17, A0A8C0TT90, A0A8C0TXP6, A0A8I3SAH4
    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  3. XM_535078.7 → XP_535078.2  tyrosine-protein kinase Lyn isoform X1

    UniProtKB/TrEMBL
    A0A8C0TXP6, A0A8I3Q113
    Conserved Domains (3) summary
    cd10364
    Location:125 → 225
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:67 → 122
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:239 → 510
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn

  4. XM_005637999.2 → XP_005638056.1  tyrosine-protein kinase Lyn isoform X2

    UniProtKB/TrEMBL
    A0A8C0KS17, A0A8C0TT90, A0A8C0TXP6, A0A8I3SAH4
    Conserved Domains (3) summary
    cd10364
    Location:104 → 204
    SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
    cd12004
    Location:46 → 101
    SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
    cd05072
    Location:218 → 489
    PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous